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3D (three-dimensional) bioprinting preparation method for tissue engineering meniscus scaffold

A technology of tissue engineering and bioprinting, which is applied in the preparation of scaffold materials for biomedical tissue engineering, and the field of 3D bioprinting preparation of tissue engineering meniscus three-dimensional scaffolds, which can solve the problems of dispersing stress and resisting shear force that cannot meet clinical needs.

Active Publication Date: 2015-11-04
深圳尤尼智康医疗科技有限公司
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Problems solved by technology

Due to the limitations of technology and equipment technology, the preparation of osteochondral scaffolds is currently limited in terms of integrated forming, so the repaired tissue is still unable to disperse stress, resist shear force, and limit the free exchange of tissue fluid between bone and cartilage. Meet clinical needs

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  • 3D (three-dimensional) bioprinting preparation method for tissue engineering meniscus scaffold
  • 3D (three-dimensional) bioprinting preparation method for tissue engineering meniscus scaffold
  • 3D (three-dimensional) bioprinting preparation method for tissue engineering meniscus scaffold

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Embodiment Construction

[0028] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments.

[0029] A 3D bioprinting preparation method for a tissue engineered meniscus scaffold, which uses nuclear magnetic resonance (MRI) to image the intact meniscus corresponding to the damaged meniscus in the patient's intact knee joint, and uses the MRI imaging data to reconstruct the meniscus for repair Plate three-dimensional model, with the help of 3D bioprinting equipment to prepare the meniscus scaffold, implanted in cell culture. The invention prepares the meniscus bracket by 3D bioprinting, can accurately control the structure and porosity of the bracket, and facilitates cell adhesion and reproduction, and at the same time, the selected degradable material meets the biocompatibility and mechanical performance requirements of the meniscus bracket. Specifically include the following steps:

[0030] 1) The construction of a three-dimens...

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Abstract

The invention provides a 3D (three-dimensional) bioprinting preparation method for a tissue engineering meniscus scaffold and provides a novel technological method for tissue engineering meniscus research. The method includes the steps of 1), constructing a three-dimensional model of meniscus so as to obtain a CAD (computer-aided design) data model with multi-layer sections; 2), preparing a degradable biological scaffold material P (LLA-CL); 3), adding the scaffold material P (LLA-CL) into a cartridge of a 3D bio-printer, and printing to obtain the three-dimensional meniscus scaffold capable of loading cells according to the CAD data model; 4), injecting growth factors into the three-dimensional meniscus scaffold through the 3D bio-printer so as to obtain meniscus tissues; 5), completing meniscus transplantation.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and is particularly suitable for the preparation of scaffold materials for biomedical tissue engineering, specifically a 3D bioprinting preparation method for a three-dimensional tissue engineering meniscus scaffold. Background technique [0002] The meniscus is composed of fibrocartilage and is an important part of the knee joint. It has important functions such as absorbing shock, transmitting load, nourishing articular cartilage, lubricating and increasing the joint contact area, and maintaining joint stability. It can also relax the femur and tibia to a certain extent. inconsistencies between. After severe injury or resection of the meniscus, the protective effect of the meniscus on the articular cartilage is lost, and the degeneration of the articular cartilage is accelerated, resulting in instability of the knee joint, disorder of load transmission, and even the occurrence of ost...

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Application Information

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IPC IPC(8): A61L27/22A61L27/18A61L27/58
Inventor 王红施敏超张楠
Owner 深圳尤尼智康医疗科技有限公司
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