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Application of 5alpha-androstane-3beta,5,6beta-triol and analogues thereof in prevention and treatment of altitude disease caused by hypobaric hypoxia

A technology of hypobaric hypoxia and analogs, used in medical preparations containing active ingredients, drug delivery, blood diseases, etc.

Active Publication Date: 2015-11-04
GUANGZHOU CELLPROTEK PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the research and development of drugs for altitude sickness is mainly aimed at improving oxygen-carrying capacity, cytokines, and inflammatory responses. The representative drugs of the former are carbonic anhydrase inhibitors such as acetazolamide, and the latter represent drugs such as glucocorticoids and some Antioxidants[1], but none of the drugs are neuroprotectants

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  • Application of 5alpha-androstane-3beta,5,6beta-triol and analogues thereof in prevention and treatment of altitude disease caused by hypobaric hypoxia
  • Application of 5alpha-androstane-3beta,5,6beta-triol and analogues thereof in prevention and treatment of altitude disease caused by hypobaric hypoxia
  • Application of 5alpha-androstane-3beta,5,6beta-triol and analogues thereof in prevention and treatment of altitude disease caused by hypobaric hypoxia

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Embodiment Construction

[0029] Further explain the present invention by specific embodiment below, but the present invention is not limited in the embodiment.

[0030] Verification of new application of 5α-androst-3β,5,6β-triol

[0031] 1. Animals: 17 healthy male cynomolgus monkeys (Macaca fascicularis), aged 6 to 6.5, weighing 6.8-7.5Kg. The use of experimental animals was approved by the Experimental Animal Management and Use Committee and the Experimental Animal Ethics Committee, and the experimental protocol complied with the principles and regulations of animal protection, animal welfare and ethics.

[0032] Seventeen male cynomolgus monkeys were randomly divided into 3 groups (Table 1):

[0033] Table 1: Explanation of groups of experimental animals

[0034]

[0035] 2. Main instruments and parameters: Plateau environment simulation hypobaric chamber group is a low-temperature and low-pressure experimental platform system for simulating plateau environment. It can automatically control ...

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Abstract

Provided are a use of 5α-androstane-3β,5,6β-triol and analogues thereof in the preparation of a drug for treating or preventing altitude sickness induced by hypobaric hypoxia.

Description

technical field [0001] The present invention relates to the novel pharmaceutical application of the compound 5α-androst-3β, 5,6β-triol and its analogues. Background technique [0002] As the altitude rises, the atmospheric pressure decreases and the partial pressure of oxygen decreases. The low partial pressure of oxygen in inhaled gas leads to a decrease in partial pressure of oxygen in arterial blood, a decrease in oxygen content, and insufficient oxygen supply to tissues. This low-pressure hypoxia (hypobaric hypoxia, HH) mainly occurs in the special environment of the plateau, also known as high altitude hypoxia. [0003] When an individual has recently arrived at an area above 2,500 meters above sea level, when acute hypobaric hypoxia (Acute Hypobaric Hypoxia) occurs, if the individual cannot adapt to this environmental change, high-altitude headache (HAH) and acute plateau headache will occur successively. Acute mountain sickness (AMS), and AMS can further develop into...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/565A61K31/575A61P25/00A61P7/10
CPCA61K31/56A61K31/565A61K31/575A61P11/00A61P25/00A61P43/00A61P7/00A61P7/10A61P9/00A61P9/10A61P9/12A61K9/0019A61K31/568
Inventor 银巍陈婕思颜光美陆秉正朱文博胡海燕邱鹏新黄奕俊张静夏
Owner GUANGZHOU CELLPROTEK PHARMA
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