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Imidafenacin oral fast dissolving film and preparation method and application thereof

An oral instant film, midanacin technology, applied in the field of medicine, can solve the problems of low mechanical strength, packaging of finished products, difficult transportation, low hardness of oral disintegrating tablets, etc.

Inactive Publication Date: 2015-11-04
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Orally disintegrating tablets usually have low hardness and low mechanical strength, which brings difficulties to the packaging and transportation of finished products

Method used

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  • Imidafenacin oral fast dissolving film and preparation method and application thereof
  • Imidafenacin oral fast dissolving film and preparation method and application thereof
  • Imidafenacin oral fast dissolving film and preparation method and application thereof

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Embodiment 1

[0032]

Embodiment 2

[0034]

Embodiment 3

[0036]

[0037]

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to an imidafenacin oral fast dissolving film and a preparation method and application thereof. The film agent comprises, by weight, 0.1%-3% of imidafenacin, 40%-85% of film-forming materials, 15%-50% of filling agents, 1%-10% of plasticizers, 0.1%-4% of sweetening agents and 0-5% of disintegrating agents. When the imidafenacin oral fast dissolving film is placed on the tongue, the film can be dissolved rapidly in saliva, medicine can be released, medicine taking through water is not needed, the danger of blocking throats does not exist, the imidafenacin oral fast dissolving film is suitable for being taken by elderly patients, the adaptability of the patients is improved, and carrying is convenient.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral instant film with midanacin as an active ingredient, a preparation method and application thereof. Background technique [0002] Midanacin is a new type of diphenylbutyramide anticholinergic drug jointly developed by Japan Ono Pharmaceutical Co., Ltd. and Kyorin Pharmaceutical Co., Ltd. It has high bladder selectivity and is used for the treatment of overactive bladder. It was launched in Japan in June 2007 . Midanacin has a diphenylbutyramide structure and is a new type of high-efficiency anticholinergic drug. It selectively acts on M3 and M1 receptors, blocks the contraction of choline on the detrusor muscle, and relaxes the detrusor muscle. Taking 0.1 mg of midanacin twice a day can significantly improve symptoms such as urgency, frequency, and incontinence caused by overactive bladder. Midanacin has dual effects of inhibiting the contraction of bladder ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4164A61K47/42A61K47/36A61K47/38A61K47/32A61P13/10
Inventor 阎卉王成港
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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