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Long-acting composite vitamin oral emulsion for livestock and preparation method thereof

A technology of complex vitamins and vitamins, which is applied in the direction of medical preparations containing active ingredients, emulsion delivery, drug combination, etc., can solve problems such as difficulty in meeting the needs of pigs, inability of ingredients to exist at the same time, and low bioavailability of powders. Achieve the effects of convenient clinical administration, long acting time, and saving manpower and material resources

Active Publication Date: 2015-10-28
郑州赛科药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although various vitamins, minerals and other nutrients are also added to the feed, it is difficult to meet the needs of pigs
Most of the products used for nutritional supplements on the market are compound multidimensional powders, and the bioavailability of powders is relatively low, which is not conducive to the absorption of nutrients; if it is made into liquid preparations, due to the influence of drug compatibility, many ingredients cannot exist at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Each 100ml long-acting veterinary multivitamin oral emulsion contains the following components: 5 million units of vitamin A, 500,000 units of vitamin D, 4g of vitamin E, and vitamin B 1 2.5g, vitamin B 2 1g, vitamin B 6 5g, vitamin C10g, Tween-80 2g, Span-80 2g, propylene glycol 20ml, soybean lecithin 5g, sodium bisulfite 1g, EDTA-2Na 0.05g, and the balance is water for injection.

[0021] Dosing: (1) Take 50ml of water for injection, add vitamin B1, vitamin B2, vitamin B6, vitamin C, dissolve and add Tween-80, set aside;

[0022] (2) Add soybean lecithin to propylene glycol, heat to 80°C and stir to dissolve, then add vitamin A, vitamin D, vitamin E, Span-80 and stir evenly;

[0023] (3) Take 5ml of water for injection, add sodium bisulfite and EDTA-2Na and stir until dissolved;

[0024] (4) Add the mixed solution obtained in step (1) into the mixed solution obtained in step (2), and stir while adding until it becomes a milky liquid, then add the mixed solution obt...

Embodiment 2

[0027] Each 100ml long-acting veterinary multivitamin oral emulsion contains the following components: 5 million units of vitamin A, 1 million units of vitamin D, 4g of vitamin E, and vitamin B 1 5g, vitamin B 2 1g, vitamin B 6 8g, vitamin C 5g, Tween-60 3g, Span-65 3g, soybean lecithin 5g, glycerol 30ml, sodium bisulfite 1g, EDTA-2Na 0.05g, and the balance is water for injection.

[0028] Dosing: (1) Take 50ml of water for injection, add vitamin B1, vitamin B2, vitamin B6, vitamin C, dissolve and add Tween-60 for later use;

[0029] (2) Add soybean lecithin to glycerol, heat to 85°C and stir to dissolve, then add vitamin A, vitamin D, vitamin E, Span-65 and stir evenly;

[0030] (3) Take 8ml of water for injection, add sodium bisulfite and EDTA-2Na and stir until dissolved;

[0031] (4) Add the mixed solution obtained in step (1) into the mixed solution obtained in step (2), and stir while adding until it becomes a milky liquid, then add the mixed solution obtained in step...

Embodiment 3

[0034] Each 100ml long-acting veterinary multivitamin oral emulsion contains the following components: 8 million units of vitamin A, 800,000 units of vitamin D, 8g of vitamin E, and vitamin B 15g, vitamin B 2 2g, vitamin B 6 7g, vitamin C8g, Tween-80 2g, Span-65 2g, soybean lecithin 10g, DMF25ml, sodium bisulfite 2g, EDTA-2Na 0.1g, and the balance is water for injection.

[0035] Dosing: (1) Take 50ml of water for injection, add vitamin B1, vitamin B2, vitamin B6, vitamin C, dissolve and add Tween-80, set aside;

[0036] (2) Add soybean lecithin to DMF, heat to 90°C and stir to dissolve, then add vitamin A, vitamin D, vitamin E, Span-65 and stir evenly;

[0037] (3) Take 10ml of water for injection, add sodium bisulfite and EDTA-2Na and stir until dissolved;

[0038] (4) Add the mixed solution obtained in step (1) into the mixed solution obtained in step (2), and stir while adding until it becomes a milky liquid, then add the mixed solution obtained in step (3), dilute to 1...

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Abstract

The invention belongs to the technical field of oral emulsion preparations, and particularly relates to long-acting composite vitamin oral emulsion for livestock and a preparation method thereof. The emulsion comprises vitamin A, vitamin D, vitamin E, vitamin B, vitamin B2, vitamin B6, vitamin C, non-ionic surface active agents A, non-ionic surface active agents B, soybean lecithin, a solvent, an antioxidant, EDTA-2Na and the balance water for injection. According to the long-acting composite vitamin oral emulsion for the livestock and the preparation method thereof, the particle size of the prepared emulsion ranges from 0.1 micron to 50 microns, the prepared emulsion is prone to being absorbed after the emulsion enters livestock bodies, the acting time is long, clinical administration is convenient, the emulsion is suitable for community administration, and the manpower and the material resources are saved.

Description

technical field [0001] The invention belongs to the technical field of oral emulsion preparations, and in particular relates to a long-acting multivitamin oral emulsion for animals and a preparation method thereof. Background technique [0002] In recent years, pig farms have paid more and more attention to nutritional supplements for pigs. Vitamins are a class of low-molecular compounds necessary to maintain normal metabolism and functions of animals. Most of them must be obtained from food, and only a few can be synthesized in the body. Each vitamin has its specific function on the animal body. When the body is deficient, it can cause metabolic dysfunction, growth arrest, production performance, fecundity or disease resistance decline, etc., and even death in severe cases. [0003] Although nutrients such as various vitamins and minerals are also added in the feed, it is difficult to meet the needs of pigs. Most of the products used for nutritional supplements...

Claims

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Application Information

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IPC IPC(8): A61K31/59A61K9/107A61P3/02A61K31/525A61K31/51A61K31/4415A61K31/375A61K31/355A61K31/07
Inventor 孙书华
Owner 郑州赛科药业科技有限公司
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