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Medicine composition for treating Alzheimer's disease and preparing method and application of medicine composition

A technology for senile dementia and composition, which is applied in the field of pharmacy, can solve the problems of complex ingredients, inaccurate curative effect, poor curative effect of senile dementia, etc., and achieve the effect of simple components, significant curative effect, and no toxic and side effects

Active Publication Date: 2015-10-21
四川医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These large-prescription pharmaceutical compositions have complex ingredients, inaccurate curative effects, and poor efficacy in treating senile dementia

Method used

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  • Medicine composition for treating Alzheimer's disease and preparing method and application of medicine composition
  • Medicine composition for treating Alzheimer's disease and preparing method and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The raw medicinal materials are weighed according to the following proportions by weight: 20 parts of Acanthopanax, 14 parts of litchi core.

[0037] The above-mentioned medicinal materials are prepared into a pharmaceutical composition for treating senile dementia as follows:

[0038] (1) Take Acanthopanax, decoct and extract 3 times with water, add 8 times the volume of water for decoction for 2 hours and filter for the first time, add 8 times the volume of water for the second time, decoct for 1 hour and filter, and add 8 times the volume of water for 1 hour 6 times the volume of water was decocted and extracted for 1 hour, filtered, the filtrates were combined, concentrated under reduced pressure, and dried to obtain the extract of Acanthopanax senticosus with a yield of 4.91%;

[0039] (2) Take lychee core medicinal material, crush it into coarse powder, add water to decoct and extract 3 times, first add 8 times the volume of water to decoct, extract for 2 hours an...

Embodiment 2

[0042] The raw medicinal materials are weighed according to the following proportions by weight: 10 parts of Acanthopanax acanthopanax, 14 parts of lychee core.

[0043] The preparation method is the same as in Example 1 to obtain pharmaceutical composition B.

Embodiment 3

[0045] The raw medicinal materials are weighed according to the following proportions by weight: 50 parts of Acanthopanax, 40 parts of lychee core.

[0046] The preparation method is the same as in Example 1 to obtain pharmaceutical composition C.

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Abstract

The invention discloses a medicine composition for treating the Alzheimer's disease. The medicine composition is prepared from, by weight, 10-50 parts of eleutherococcus senticosus and 7-56 parts of lychee seed. According to the medicine composition, only two traditional Chinese medical materials of the eleutherococcus senticosus and the lychee seeds are in compatibility and added into medicine, the ratio of the weight parts of the eleutherococcus senticosus and the lychee seeds are adjusted that the eleutherococcus senticosus has 10-50 parts and the lichee seeds have 7-56 parts, the eleutherococcus senticosus and the lychee seeds play the synergistic interaction effect, the treatment effect for treating the Alzheimer's disease is obvious, the components of the medicine composition are simple, the quality is easy to control, and the treatment effect is definite. The invention further provides a preparing method of the medicine composition, according to the preparing method, medicine active components in the medical materials of the eleutherococcus senticosus and the lychee seeds can be extracted effectively, and operation is simple. The invention further provides the application of the medicine composition in preparing medicine for relieving recognition memory dysfunctions.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating senile dementia and its preparation method and application. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is one of the most common neurodegenerative diseases, and its main pathological feature is senile plaques with amyloid β-protein (Aβ) deposition as the core (senile plaques, SPs) and intracellular neurofibrillary tangles (neurofibrillary tangles, NFTs) formed by hyperphosphorylated tau protein. With the aging of the global population and the improvement of life expectancy, the prevalence, morbidity and mortality of AD are increasing rapidly. It is estimated that by 2020, there will be more than 30 million Alzheimer's patients worldwide. China is the country with the largest base of elderly population and AD patients in the world, and also the country with the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P25/28
Inventor 秦大莲吴建明唐勇陈海霞李华曾媛
Owner 四川医科大学
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