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Application of flos chrysanthemi indici extract

A technology of wild chrysanthemum flower extract and mongolic acid, applied in the field of medicine, can solve problems such as large side effects, and achieve the effect of reducing serum uric acid level and improving human health.

Active Publication Date: 2015-09-23
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have obvious uric acid-lowering effects, they also have relatively large side effects, such as rash, fever, liver and kidney dysfunction, abnormal hematopoietic function, gout attacks, etc., thus limiting the scope of their application.

Method used

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  • Application of flos chrysanthemi indici extract
  • Application of flos chrysanthemi indici extract
  • Application of flos chrysanthemi indici extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Preparation of wild chrysanthemum extract (prior art).

[0014] (1) 2.5 kg of wild chrysanthemum, add 10 times the mass fraction of 75% alcohol, extract three times at 100 ° C, each time for 1 hour, press slightly, and then concentrate to extract;

[0015] (2) Add 1-2L of alcohol with a mass fraction of 20%, dissolve at 50-60°C, and centrifuge to collect the precipitate;

[0016] (3) Add 300ml of ether to wash for two or three times until it is colorless, then add 300ml of ethyl acetate to dissolve once, and centrifuge to collect the precipitate;

[0017] (4) Wash once with a mixed solution of ethyl acetate / ethanol (240ml:60ml), and then once with absolute ethanol below 200ml;

[0018] (5) Add 1 L of ethanol with a mass fraction of 40%, dissolve at 80°C, centrifuge while hot to take the precipitate and dry it. Remember to get the extract of chrysanthemum flower, in which the mass percentage of mongoside is not less than 50%.

Embodiment 2

[0019] Embodiment 2: pharmacodynamic experiment

[0020] 1. Preventive medication

[0021] Animal grouping: 40 male SD rats of clean grade, after 14 days of adaptive feeding with common feed, blood was collected from the fundus venous plexus of the rats in glass capillary tubes, and the supernatant was collected by centrifugation. According to the serum uric acid value of the experimental animals, they were randomly divided into 4 groups. Control group, model control group, positive drug (allopurinol) group, wild chrysanthemum flower extract (Chr.E) group (80 mg / kg), 10 rats in each group. There was no significant difference in the baseline serum uric acid value among the groups (P>0.05). Except for the normal group given normal feed, the other groups were given feed containing yeast extract and adenine every day, and they had free access to food and water during the experiment.

[0022] Pathological model: Except the normal group was given normal feed, the other groups were...

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Abstract

The invention discloses the application of a flos chrysanthemi indici extract. Linarin is contained in the flos chrysanthemi indici extract, the mass percent of the linarin is not smaller than 50 percent, the application of the flos chrysanthemi indici extract is as follows: the flos chrysanthemi indici extract is used for preventing or curing hyperuricemia. According to the invention, through the combination of the linarin contained in the flos chrysanthemi indici extract, the characteristic of lowering xanthine oxidase activity can be achieved, and the flos chrysanthemi indici extract can be used for preventing or curing hyperuricemia, can remarkably lower the serum uric acid level of a model rat, can lower the levels of serum creatinine and urea nitrogen, has the advantages of easiness in component separation, controllability in quality, low additive dose, remarkable effects and the like, and has a great and profound significance in improving human health.

Description

technical field [0001] The invention belongs to the technical field of medicine, and the invention relates to the application of wild chrysanthemum flower extract (the content of mongoside not less than 50%) in the prevention and / or prevention and treatment of hyperuricemia, which can significantly reduce the serum concentration of hyperuricemia rats. uric acid value. Background technique [0002] Wild chrysanthemum is the dry capitulum of Chrysanthemum indicum L., a perennial herb of the genus Chrysanthemum in the family Asteraceae, also known as "bitter barley", "mountain wild chrysanthemum", "roadside chrysanthemum" and "wild yellow chrysanthemum". Wild chrysanthemum is a traditional medicine. It is recorded in "Bielu of Famous Doctors": "bitter, pungent, and slightly cold", and has the effects of "clearing heat, detoxifying, calming the liver". There are also records in "Compendium of Materia Medica": wild chrysanthemum clears heat and detoxifies, relieves fire and impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/287A61P19/06
Inventor 吕圭源陈素红庞敏霞马莹莹
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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