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New function of Dittany Bark active component for promoting increment expression of 5-hydroxytryptamine

A technology of active ingredients and white fresh skin, applied in the direction of organic active ingredients, medical preparations containing active ingredients, nervous system diseases, etc.

Active Publication Date: 2015-09-09
泰州市新滨江开发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the functional effect of the extract of white fresh bark on the central nervous system.

Method used

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  • New function of Dittany Bark active component for promoting increment expression of 5-hydroxytryptamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The separation process of the active ingredient of white fresh skin is:

[0018] Use 95% ethanol and 10 times of 70% ethanol to recover and extract 5 kg of white fresh cortex successively for three times, each time for one hour, combine the extracts, concentrate to obtain extract and suspend with water, then use petroleum ether, two Methylene chloride and ethyl acetate were extracted to obtain about 50 g of dichloromethane extracts, which were the active ingredients of the Cortex Dictatus.

Embodiment 2

[0020] 10kg of white fresh cortex was sequentially recovered and extracted three times with 95% ethanol and 10 times of 70% ethanol, each time for one hour, the extracts were combined, concentrated to obtain extracts and suspended with water, then sequentially used petroleum ether, dichloro Extract with methane and ethyl acetate to obtain about 100 g of dichloromethane extract, which is the active ingredient of the Cortex Dictatus.

Embodiment 3

[0022] Use 95% ethanol and 10 times of 70% ethanol to recover and extract 8 kg of white fresh cortex successively for three times, each time for one hour, combine the extracts, concentrate to obtain extract and suspend with water, then use petroleum ether, two Methylene chloride and ethyl acetate were used for extraction to obtain about 80 g of dichloromethane extracts, which were the active ingredients of the Cortex Dictatus.

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Abstract

Dittany Bark is an important traditional Chinese medicinal material. The invention discloses a new function of a Dittany Bark active component. The experiment on the action of the Dittany Bark active component on rat primary culture neurons detects that the Dittany Bark active component can promote overexpression of 5-hydroxytryptamine receptor gene 5HTR1A. Since the 5-hydroxytryptamine can have important influence on emotions, memory and other behaviors of neurons, the result indicates that the Dittany Bark active component can promote the changes of human hedonia, long-time-interval memory and other functions.

Description

technical field [0001] This application belongs to the technical field of new functions of active ingredients of medicinal materials, and in particular relates to a new function that an active ingredient isolated from the traditional Chinese medicinal material Radix Cortex can promote the increased expression of 5-hydroxytryptamine receptors in hippocampal neurons. Background technique [0002] 5-hydroxytryptamine, also known as serotonin, is an inhibitory neurotransmitter, which is widely distributed in various brain regions, especially in the cerebral cortex. 5-Hydroxytryptamine is the most widely studied neurotransmitter. It is involved in various life processes such as emotions, memory, and energy. Abnormalities in its expression and function are closely related to the occurrence of various neurological diseases. Schizophrenia and bipolar disorders. 5HTR1A It is an important subtype of 5-hydroxytryptamine receptor, which is widely distributed in the brain. It participat...

Claims

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Application Information

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IPC IPC(8): C07D491/048A61K31/4741A61P25/18A61P25/28
CPCA61K31/4741C07D491/048
Inventor 不公告发明人
Owner 泰州市新滨江开发有限责任公司
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