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Method for researching preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis)

A technology of Clostridium butyricum and live bacteria, applied in the field of medical research, can solve problems such as the inability to implement breastfeeding and the delay in the establishment of normal flora

Inactive Publication Date: 2015-08-26
XINXIANG MEDICAL UNIV
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Problems solved by technology

Premature infants are mostly born by cesarean section, unable to implement breastfeeding, and the establishment of normal flora in the gastrointestinal tract is often delayed due to the use of antibiotics

Method used

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  • Method for researching preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis)
  • Method for researching preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis)
  • Method for researching preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis)

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Embodiment Construction

[0015] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0016] figure 1 Shows the flow chart of the research method for the preventive effect of Clostridium butyricum dual live bacteria powder on the small intestine and colon. Research methods for preventive effects include:

[0017] S101. Select the research objects, and divide the selected children into an intervention group and a control group according to the random number table method. The children who have been prophylactically using Clostridium butyricum dual live bacteria powder for more than 7 days are used as the intervention group, and no probiotics are used at all. The children in the gro...

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Abstract

The invention discloses a method for researching a preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis). The method comprises steps as follows: research objects are selected, and selected sick children are divided into an intervention group and a control group according to a random number table; clinical data of the two groups of sick children are collected by adopting an investigation list; the collected data are subjected to statistical processing, and the inspection level P is equal to 0.05. According to the embodiment of the invention, the NEC morbidity of the intervention group and the NEC morbidity of the control group are 6.25% and 13.27% respectively, the morbidity difference of the two groups does not have the statistical significance, the difference of mortality rates of the two groups does not have the statistical significance, but when the total number of people suffering from NEC and death is taken as the whole for statistical analysis again, the condition that the death risk or risk of the NECIIA-IIIB stage of the intervention group are lower than those of the control group can be found out.

Description

technical field [0001] The invention belongs to the field of medical research, and in particular relates to a research method for the preventive effect of clostridium butyricum dual live bacteria powder on the small intestine and colon. Background technique [0002] Neonatal necrotizing enterocolitis (NEC) is the most common acute abdomen in newborns, especially premature infants. The incidence of NEC is negatively correlated with the gestational age / weight ratio. [0003] NEC is a disease caused by a combination of factors and has not yet occurred in a sterile animal model. The reduction of normal flora and the increase of pathogenic bacteria are one of the important factors leading to the occurrence of NEC. Most premature infants are born by cesarean section, unable to implement breastfeeding, and the establishment of normal flora in the gastrointestinal tract is often delayed due to the use of antibiotics. Contents of the invention [0004] The purpose of the present ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/00A61K35/742
Inventor 赵林静马玉龙李银生李敏王沛珍
Owner XINXIANG MEDICAL UNIV
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