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Traditional Chinese medicine composition with anti-brain cancer activity and its preparation method and application

A technology of composition and activity, which is applied in the field of traditional Chinese medicine composition with anti-brain cancer activity and its preparation, can solve the problems of large dosage, many impurity components, slow onset of action, etc., and achieve less dosage and scientific and reasonable proportioning , fast absorption effect

Active Publication Date: 2018-05-01
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, the current reported anti-brain cancer drugs have a large dosage, many impurities, and slow onset of action.

Method used

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  • Traditional Chinese medicine composition with anti-brain cancer activity and its preparation method and application
  • Traditional Chinese medicine composition with anti-brain cancer activity and its preparation method and application
  • Traditional Chinese medicine composition with anti-brain cancer activity and its preparation method and application

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preparation example Construction

[0036] 2. the preparation method of the Chinese medicine composition with anti-brain cancer activity of the present invention, it may further comprise the steps:

[0037] (1) Take 10 grams of Radix Aconiti, 15 grams of Shanzi mushroom, 10 grams of Southern Star, 10 grams of Eupatorium, and 10 grams of Alisma by weight, add ethanol with 15 times the volume of the total medicinal material weight, soak for 48 hours, Then ultrasonication, continuous reflux extraction for 3 times, each time for 1 hour, combined extracts, concentrated, the concentrate was put on a macroporous resin column, eluted with water, 20% ethanol to 60% ethanol in sequence, and collected 40 to 50% ethanol eluate , concentrated to obtain the extract;

[0038] (2) Get 3 grams of centipede by parts by weight, continuously reflux extraction with sherwood oil 3 times, each 2 hours, get sherwood oil extract, concentrate and dry, get centipede extract;

[0039] (3) Take the extract obtained in step (1) and the cent...

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Abstract

The invention discloses a traditional Chinese medicine composition with anti-brain cancer activity, its preparation method and its application. The traditional Chinese medicine compound composition is composed of 10-30 parts of white aconite, 15-45 parts of Arrowhead mushroom, and 3-9 parts of centipede , made of 10-30 parts of Nanxing, 10-30 parts of Eupatorium, and 10-30 parts of Alisma. Experimental results show that the traditional Chinese medicine composition with anti-brain cancer activity provided by the present invention has scientific and reasonable proportioning, rigorous medication, anti-cancer and detoxification, phlegm-reducing and collateral-relieving effects, and has strong killing effect on brain cancer cells both in vivo and in vitro. It can promote the production of tumor necrosis factor, improve the immunity of tumor patients, and has high safety and low toxic and side effects. The preparation method provided by the invention has stable quality, high content of extracted active ingredients, strong operability, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine composition with anti-brain cancer activity and its preparation method and application. Background technique [0002] Intracranial tumors are also known as brain tumors, whose etiology is still unknown. Tumors originating from the brain, meninges, pituitary gland, cranial nerves, cerebrovascular and embryonic remnants are called primary intracranial tumors. Secondary intracranial tumors are those that metastasize to the intracranial from malignant tumors in other organs and tissues of the body. [0003] A worldwide statistic of the prevalence of intracranial tumors is 40 / 100,000. It shows that the incidence of intracranial tumors is not low, which deserves attention. As far as the incidence rate of systemic tumors is concerned, brain tumors rank fifth (6.31%), only lower than gastric, uterine, breast, and esophageal tumors. In adults, brain tumor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P35/00A61K35/648
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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