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A traditional Chinese medicine composition with anti-gastric cancer activity and its preparation method and application

A composition and active technology are applied in the field of traditional Chinese medicine compositions with anti-gastric cancer activity and their preparation fields, which can solve the problems of unfavorable curing of gastric cancer, many impurity components, large dosage of drugs, etc., and achieve the inhibition of gastric cancer cell growth and the scientific and reasonable ratio. , the effect of prolonging survival

Active Publication Date: 2018-04-03
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current reported anti-gastric cancer drugs have a large dosage, many impurities, and slow onset of action, which is also a burden on the stomach and is not conducive to curing gastric cancer.

Method used

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  • A traditional Chinese medicine composition with anti-gastric cancer activity and its preparation method and application
  • A traditional Chinese medicine composition with anti-gastric cancer activity and its preparation method and application
  • A traditional Chinese medicine composition with anti-gastric cancer activity and its preparation method and application

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preparation example Construction

[0036] 2. the preparation method of the Chinese medicine composition with antigastric cancer activity of the present invention, it comprises the following steps:

[0037] (1) Take 15 grams of Codonopsis pilosula, 10 grams of Radix Ophiopogon japonicus, 20 grams of Hedyotis diffusa, 15 grams of Agrimony, 15 grams of Shi Jianchuan, and 10 grams of Pinellia fragrans by weight, and add 12 times the volume of the total medicinal materials 60% ethanol (volume concentration), continuous reflux extraction for 3 times, each time for 2 hours, combined extracts, concentrated under reduced pressure at 50-70 degrees Celsius to obtain a macroporous adsorption resin column on the concentrate, first eluted with water, and then sequentially Elute with ethanol with a volume concentration of 20% to 80%; collect the ethanol eluate with a combined volume concentration of 60% to 80%, and concentrate to obtain an extract;

[0038] (2) Take the extract obtained in step (1), add lactose and cornstarch...

Embodiment 6

[0071] The clinical trial results of the Chinese medicine composition with anti-gastric cancer activity provided by the present invention show that: 46 cases of gastric cancer patients who were clinically diagnosed were selected, and after taking the Chinese medicine composition with anti-gastric cancer activity provided by the invention (Example 1 of the invention), after 2 According to clinical observation within one month, the tumor patients who took the Chinese medicine compound composition provided by the invention had obvious improvement in clinical symptoms such as stomach pain and indigestion, and the quality of life of gastric cancer patients was improved. It shows that the traditional Chinese medicine composition with anti-gastric cancer activity provided by the present invention can protect and improve immune function, and the effective rate of clinical observation is 85.7%.

[0072] According to the theory of traditional Chinese medicine, the present invention adopt...

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Abstract

The invention discloses a traditional Chinese medicine composition with anti-gastric cancer activity, its preparation method and its application. The traditional Chinese medicine composition consists of 15-45 parts of Ludangshen, 10-30 parts of Ophiopogon japonicus, 20-60 parts of Hedyotis diffusa, Agrimony 15-45 parts, Ishimi Chuan 15-45 parts, and Pinellia 10-30 parts. The traditional Chinese medicine composition with anti-gastric cancer activity provided by the invention has scientific and reasonable proportioning, rigorous medication, and has the effects of anti-cancer and detoxification, reducing phlegm and removing blood stasis, replenishing qi, nourishing stomach and nourishing yin, and the like. Experimental results show that it has a strong killing effect on gastric cancer cells, can promote the production of tumor necrosis factor, improve the immunity of tumor patients, and has high safety and low toxic and side effects. The preparation method provided by the invention has stable quality, high content of extracted active ingredients, strong operability, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine composition with anti-gastric cancer activity and its preparation method and application. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of more than 6 million people dying of various tumor diseases every year. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. [0003] With the increasingly serious environmental pollution, water pollution, food pollution, and people's irregular diet, diet diversification, alienation, prone to stomach cancer. Clinically, the current drugs for the treatment of tumors including gastric cancer are mainly chemical drugs, but due to the high toxicity of chemotherapy drugs, they can not only kill tumor cells, but also non-selectively kill the body's own immune cells su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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