Electrical stimulation method for observing rat craniotomy motor cortex with adjustable waveform and amplitude

A technology of electrical stimulation and cerebral cortex, applied in medical science, artificial respiration, sensors, etc., can solve problems that have not yet been seen in relevant literature, patent reports, etc., and achieve the effect of controllable voltage amplitude

Inactive Publication Date: 2015-08-12
杨旭明 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Develop an electrical stimulator with arbitrarily adjustable waveform and amplitude through a rat craniotomy motor cortex electrical stimulation observation method with adjustable waveform and amplitude, and complete the method of electrically stimulating the motor area of ​​the cerebral cortex to cause body movement effects. Patent report

Method used

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  • Electrical stimulation method for observing rat craniotomy motor cortex with adjustable waveform and amplitude
  • Electrical stimulation method for observing rat craniotomy motor cortex with adjustable waveform and amplitude
  • Electrical stimulation method for observing rat craniotomy motor cortex with adjustable waveform and amplitude

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Embodiment Construction

[0027] Such as figure 1 Shown is that the rat of the present invention is fixed on the stereotaxic instrument, the bone window is opened, and the microelectrode cortical electrical stimulation diagram is performed;

[0028] Such as figure 2 Shown is the position of each stimulus point and the shape of each point indicates what movement it controls (forelimb, beard, neck, hindlimb, mouth);

[0029] Such as image 3 Shown is the flow chart of the electrical stimulator program;

[0030] Such as Figure 4 A schematic diagram of the negative-going square wave train output from the electrical stimulator is shown

[0031] Such as Figure 5 The schematic diagram of the electrical stimulator with adjustable waveform and amplitude is shown;

[0032] In order to observe the functional localization phenomenon of the motor area of ​​the cerebral cortex and to understand the regulation of the motor area of ​​the cortex to the body movement, the electrical stimulation experiment of th...

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Abstract

The present invention discloses an electrical stimulation method for observing rat craniotomy motor cortex with the adjustable waveform and amplitude. The method is characterized in that: the motor area of the cerebral cortex is an advanced nerve center for regulating the body motor function, and, through the downward pathway of the pyramidal and extrapyramidal system, controls activities of the brain stem and spinal motor neurons, so as to control muscle movement. Corresponding effects occur after cortical electrical stimulation, experimenters attempt to, through the electrical stimulation of the motor area of the cerebral cortex, cause the effect of body movement, and observe the phenomenon of functional localization of the motor area of the cortex. The rat is fixed to a stereotaxic apparatus, the bone windows are opened, a cortical electrical stimulation using microelectrode is performed, and the electrode is inserted vertically into the position 1.8 mm below the cortex, and adjusted within a range of +/- 200 um so as to cause the maximum movement of the contralateral forelimb, facial hair and neck corresponding to the stimulation points. An electrical stimulator with the adjustable waveform and amplitude is further produced, is capable of accurately completing the experimental observation of electrical stimulation predetermined by experimenters, and provides technical support for the experiment.

Description

technical field [0001] The invention belongs to the experimental field of electrical stimulation of rat craniotomy motor cortex in brain surgery, and in particular relates to a method for observing electrical stimulation of rat craniotomy motor cortex with adjustable waveform and amplitude. Background technique [0002] Observe the functional positioning phenomenon of the motor area of ​​the cerebral cortex, and understand the regulation of the motor area of ​​the cortex on body movement. The motor area of ​​the cerebral cortex is the high-level center that regulates the body's motor function. It controls the activity of the motor neurons in the brainstem and spinal cord through the descending pathways of the pyramidal system and the extrapyramidal system, thereby controlling muscle movement. The corresponding effect occurs after electrical stimulation of the cortex, which is called the functional positioning of the cortical motor area or the body positioning structure of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/11A61B19/00A61N1/36
Inventor 杨旭明
Owner 杨旭明
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