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Lesinurad-containing compound composition and preparation method thereof

A kind of technology of lysenoside and composition, applied in the field of preparing said composition, and can solve problems such as complicated process

Inactive Publication Date: 2015-08-05
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to solve the problem that the drug has a complex preparation process and needs to adjust the feasibility and fluidity of the active ingredient through a large number of excipients
This technology greatly solves the common problems of this type of preparation

Method used

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  • Lesinurad-containing compound composition and preparation method thereof
  • Lesinurad-containing compound composition and preparation method thereof
  • Lesinurad-containing compound composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Lesinorefebuxostat Compound Tablets

[0019] Lesinorefebuxostat Prescription:

[0020]

[0021] Preparation:

[0022] 1. Preparation of Lesnorefebuxostat Solid Composition

[0023] In the future, dissolve senorefebuxostat in ethanol respectively. After the active ingredient is completely dissolved, add MCC PH102 while stirring. After mixing evenly, volatilize the solution at 40 degrees Celsius for 10 minutes, and then rapidly raise the temperature to 65 degrees Celsius until Ethanol was evaporated completely, and then the solid composition was taken out. Pass through a 28-mesh sieve and granulate to obtain a solid composition.

[0024] 2. Preparation of Lesnorefebuxostat Tablets

[0025] Take the solid composition and add the lubricant magnesium stearate to compress the tablet to get Snorefebuxostat Tablets

Embodiment 2

[0026] Example 2 Lesnorefebuxostat Capsules

[0027] Prescription of Lesinorefebuxostat Capsules:

[0028]

[0029] Preparation:

[0030] 1. Preparation of Lesnorefebuxostat Solid Composition

[0031] In the future, dissolve senorefebuxostat in ethanol respectively. After the active ingredient is completely dissolved, add MCC PH102 while stirring. After mixing evenly, volatilize the solution at 40 degrees Celsius for 10 minutes, and then rapidly raise the temperature to 65 degrees Celsius until Ethanol was evaporated completely, and then the solid composition was taken out. Pass through a 28-mesh sieve and granulate to obtain a solid composition.

[0032] 2. Preparation of Lesnorefebuxostat Capsules

[0033] The solid composition is mixed with magnesium stearate to fill capsules.

Embodiment 3

[0034] Embodiment 3: lesinorefebuxostat granules

[0035] Prescription of Lesinorefebuxostat Capsules:

[0036]

[0037] 1. Preparation of Lesnorefebuxostat Solid Composition

[0038] In the future, dissolve senorefebuxostat in ethanol respectively. After the active ingredient is completely dissolved, add MCC PH102 while stirring. After mixing evenly, volatilize the solution at 40 degrees Celsius for 10 minutes, and then rapidly raise the temperature to 65 degrees Celsius until Ethanol was evaporated completely, and then the solid composition was taken out. Pass through a 28-mesh sieve and granulate to obtain a solid composition.

[0039] 2. Preparation of Lesnorefebuxostat Granules

[0040] The solid composition is dispensed.

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Abstract

The invention relates to a Lesinurad-containing compound composition. The Lesinurad-containing compound composition comprises Lesinurad and Febuxostat. The invention also relates to a preparation method of the Lesinurad-containing compound composition. The preparation method comprises the following steps of 1, Lesinurad-Febuxostat solid composition preparation and 2, solid agent preparation. The preparation method is simple and fast and is suitable for industrial production.

Description

Technical field: [0001] The invention relates to a compound composition for solid preparation of lesorafebuxostat, and the composition contains a mixture of lesorastat and febuxostat. The invention also relates to methods of preparing said compositions. Simultaneously, the invention also has the characteristics of simplicity and quickness, and is suitable for industrialized production. Background technique [0002] Gout is a kind of crystal arthritis caused by purine metabolism disorder and / or decreased uric acid excretion, and it is one of the common clinical diseases. Hyperuricemia is the most important biochemical basis of gout. Long-term and effective control of blood uric acid levels is the main goal of gout treatment. Allopurinol is currently the only clinical drug used to inhibit uric acid synthesis, and its curative effect has been confirmed. middle. XO can restore its activity due to the spontaneous reduction of the molybdenum active center in the enzyme, result...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61K47/38A61K9/14A61P19/06A61K31/4196
Inventor 姜海涛其他发明人请求不公开姓名
Owner FUKANGREN BIO PHARMA
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