Aerosol precursor with external medicine component for treating rhinitis and method for dispersing external medicine component into nano-order fogdrops

A technology of medicinal ingredients and external medicines, applied in the field of aerosol precursors, can solve problems such as high cost of propellants, high injection pressure, and reduced pressure in tanks, and achieve improved effective utilization, easy absorption, and specific surface area big effect

Inactive Publication Date: 2015-07-22
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The representative patent for pressurized atomization of traditional Chinese medicine compound preparations is CN102949573A, in which an 80-100bar propellant such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane is used to atomize the liquid medicine to To obtain micron-sized mist droplets, the above-mentioned injection pressure is too high, the airtightness of the propellant container tank is strict, the production cost is high, and the propellant itself is also expensive
In addition, with the increase of the amount of medicine used, the pressure inside the tank decreases continuously, and the drug atomization effect gradually becomes worse; moreover, such tanks can only be used once for consumers, increasing usage cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] An aerosol precursor comprising an external medicinal active ingredient for treating rhinitis, which comprises glycerin, propylene glycol, 1,3-butanediol, fragrance substances and compound rhinitis ointment extract for treating rhinitis, their mass ratio Glycerol: propylene glycol: compound rhinitis ointment extract for rhinitis = 40:20:1.

[0038] Wherein the compound rhinitis ointment extract for the treatment of rhinitis is obtained by the method comprising the following steps:

[0039] (1) Impurity removal: the compound rhinitis ointment is dissolved in edible grade ethanol, filtered, and insoluble impurities are removed to obtain the ethanol solution of the compound rhinitis ointment for the treatment of rhinitis;

[0040] (2) decolouring: the ethanol solution of the compound rhinitis ointment for the treatment of rhinitis obtained in the step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution eluting...

Embodiment 2

[0045] A kind of aerosol precursor that contains the medicinal effect ingredient of external medicine for treating rhinitis, it comprises glycerin, propylene glycol, 1,3-butanediol, fragrance substance and rhinitis drops extract for treating rhinitis, their mass ratio Glycerol: propylene glycol: rhinitis drops extract for rhinitis = 40:20:1.

[0046] Wherein the rhinitis drops extract for the treatment of rhinitis obtains by the method comprising the following steps:

[0047] (1) impurity removal: the rhinitis drops are dissolved in edible grade ethanol, filter, remove insoluble impurities, obtain the ethanol solution of the rhinitis drops for the treatment of rhinitis;

[0048] (2) decolouring: the ethanol solution of the rhinitis drops for the treatment of rhinitis obtained in the step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution eluting with concentration, removes the pigment component wherein; The mode...

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Abstract

The invention relates to an aerosol precursor with external medicine components for treating rhinitis. The aerosol precursor comprises glycerin, propylene glycol, 1,3-butanediol, a flavor component and an external medicine extract for treating rhinitis, wherein the mass ratio of glycerin to propylene glycol, 1,3-butanediol to a flavor component and the external medicine extract is (40-45):(20-25):(0-10):(0-10):(1-10). The invention further relates to a method for dispersing the external medicine components in the external medicines for treating rhinitis into nano-order fogdrops, and further relates to aerosol containing the nano-order fogdrops. The aerosol precursor provided by the invention comprises the external medicine effect components for treating rhinitis, nano-order fogdrops can be obtained when the external medicine effect components are heated in an electronic smoke instrument with an electric heating device, and the medicine effect components can be relatively well absorbed by human bodies.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing an external medicine for treating rhinitis and a method for dispersing it into nano-scale droplets. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity, which is the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa. At present, the traditional Chinese medicine compound preparations for treating rhinitis include external medicines for treating rhinitis. Usually, the external medicines for treating rhinitis are administered by smearing on the inside of the nasal cavity or directly dripping into the nasal cavity. There are many inconveniences in this way of administration. It is inconvenient to use when apply...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/12A61K47/48A61K47/10A24B15/16A24F47/00A61P11/02
Inventor 杨柳赵伟尚善斋雷萍段沅杏杨继韩敬美田永峰朱东来巩效伟陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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