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Composition containing melatonin and catechin as well as application of composition

A composition and technology of melatonin, applied to the use of melatonin in reducing the toxic and side effects of catechin, the field of compositions containing melatonin and catechin

Active Publication Date: 2015-07-22
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to potential safety hazards, this type of product has gone through waves of listing, removal, and re-listing

Method used

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  • Composition containing melatonin and catechin as well as application of composition
  • Composition containing melatonin and catechin as well as application of composition
  • Composition containing melatonin and catechin as well as application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Melatonin reduces EGCG lethal toxicity

[0032] It is known that single or multiple injections of high doses of EGCG can cause death in mice. This study investigated whether melatonin can reduce the lethal toxicity of EGCG.

[0033] Experimental animals: healthy Kunming mice, male, weighing 20-22 grams, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., Shanghai Experimental Animal Center, Chinese Academy of Sciences. Administration method: 16 mice were randomly divided into 2 groups, 8 in each group. In the first group, 30 minutes after intraperitoneal injection of normal saline, 70 mg / kg of EGCG was injected; in the second group, 30 minutes after intraperitoneal injection of 50 mg / kg of melatonin, 70 mg / kg of EGCG was injected; Once a day, for two consecutive days, mice in each group were sacrificed by dislocation 24 hours after the last administration. Animal Status: Animal deaths were recorded daily. Statistical analysis: log-rank test wa...

Embodiment 2

[0035] Example 2: Melatonin reduces EGCG acute liver toxicity

[0036] It is known that a single injection of high-dose EGCG can cause acute liver injury in mice. This study investigated whether melatonin can reduce EGCG-induced acute liver injury.

[0037] Experimental animals: healthy Kunming mice, male, weighing 20-22 grams, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., Shanghai Experimental Animal Center, Chinese Academy of Sciences. Administration method: 18 mice were randomly divided into 3 groups, 6 in each group. In the control group, only the same volume of normal saline was injected intraperitoneally, and the injection frequency and time were consistent with other groups; in the model group, normal saline was injected intraperitoneally for three days, once a day, and 30 minutes after the treatment on the third day, a dose of 125 mg / kg was injected. EGCG; Compatibility group, intraperitoneal injection of melatonin at a dose of 50 mg / kg for three da...

Embodiment 3

[0044] Example 3: Melatonin reduces EGCG subacute liver injury

[0045] It is known that multiple injections of high doses of EGCG can cause subacute liver injury in mice. This study investigated whether melatonin can reduce EGCG-induced subacute liver injury.

[0046] Experimental animals: healthy Kunming mice, male, weighing 20-22 grams, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., Shanghai Experimental Animal Center, Chinese Academy of Sciences. Administration method: 32 mice were randomly divided into 4 groups, 8 in each group. In the control group, only the same volume of normal saline was injected intraperitoneally, and the injection frequency and time were consistent with other groups; in the model group, normal saline was injected intraperitoneally for seven days, and 30 minutes after the treatment with normal saline on the third to seventh days, EGCG was injected at a dose of 55 mg / kg. Once a day; in the compatibility group, normal saline was repl...

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PUM

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Abstract

The invention relates to composition containing melatonin and catechin as well as an application of the composition, and in other words, composition used for foods, drugs or healthcare products contains melatonin and catechin. The combination use of melatonin and catechin in the composition can reduce toxic and side effects of catechin and greatly improve the safety of catechin, and the pharmacological action of catechin is not affected. The invention further relates to a novel application of melatonin, in particular to an application of melatonin to the preparation of the composition used for the healthcare products, the drugs or the foods; the composition is characterized by further containing catechin, wherein melatonin can reduce toxic and side effects of catechin, lethal toxicity of catechin and acute hepatotoxicity and sub-acute liver injury caused by catechin.

Description

technical field [0001] The invention relates to a composition containing melatonin and catechin, which can be applied in the fields of food, health products and medicines; and also relates to the use of melatonin in reducing the side effects of catechin. Background technique [0002] Melatonin is secreted by the pineal gland in the body and has antioxidant function. It can not only directly remove active oxygen, but also up-regulate the antioxidant system. Melatonin is known to regulate sleep, prevent and improve metabolic disorders, and numerous diseases. [0003] Metabolic dysfunction can lead to obesity, diabetes, and hyperlipidemia. With the development of society and economy and the change of lifestyle, the prevalence of metabolic diseases caused by metabolic dysfunction is increasing year by year, seriously endangering human health, and has become a global public health problem of great concern. [0004] Drinking tea is known to have health benefits. The active subs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61K47/22A61K31/353A61P3/08A61P3/06A23L1/30A23L33/10
Inventor 张劲松王东旭
Owner ANHUI AGRICULTURAL UNIVERSITY
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