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Medicine for treating ischemic cerebral arterial thrombosis

A technology of ischemic stroke and drugs, applied in the direction of drug combination, cardiovascular system diseases, amide active ingredients, etc., to achieve the effect of reducing the degree of cerebral edema, reducing inflammatory damage, and not easy to digest and degrade

Inactive Publication Date: 2015-07-08
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacologists, medical experts and various forces (governments, social groups) from various countries regard the research and development of drugs for the prevention and treatment of cerebrovascular diseases as an urgent mission, but there is no ideal drug for treatment at home and abroad

Method used

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  • Medicine for treating ischemic cerebral arterial thrombosis
  • Medicine for treating ischemic cerebral arterial thrombosis
  • Medicine for treating ischemic cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The following N15 is Z-octadec-9-ene-propanesulfonamide.

[0029] 1. Experimental materials and methods

[0030] 1) Experimental animals and reagents

[0031] Healthy Kunming mice, ♂, weighing 25-30 g, were provided by the Experimental Animal Center of Xiamen University [certificate number: SYXK (Fujian) 2013-0003]. Raised in a natural light cycle, fasted for 12 hours before the operation, and had free access to water. N15, this topic is composed.

[0032] 2) Animal handling methods

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Abstract

The invention discloses a medicine for treating ischemic cerebral arterial thrombosis, of which the active component is Z-octadecyl-9-alkenyl-propylsulfamide being 80-250 mg / kg in effective dose. The medicine is used in an oral manner. The active component of the medicine is the Z-octadecyl-9-alkenyl-propylsulfamide so that the medicine has a significant effect of treating the ischemic cerebral arterial thrombosis, can improve neurological deficit of mice, can reduce cerebral infarction volume and can alleviate the degree of encephaledema.

Description

technical field [0001] The invention belongs to the technical field of chemical medicines, in particular to a medicine for treating ischemic stroke. Background technique [0002] Cerebrovascular disease (stroke) is a disease caused by blockage or rupture of cerebral blood vessels that blocks blood flow in the brain. It is divided into ischemic stroke and hemorrhagic stroke. According to reports, the results of sample surveys of urban and rural populations in my country show that the annual incidence rates are 219 / 100,000 and 185 / 100,000, respectively, and the mortality rates are 116 / 100,000 and 141.8 / 100,000, and they tend to be younger. There are about 1.5 to 2 million new stroke patients in my country every year, and ischemic stroke accounts for about 60 to 80% of the stroke cases. In 1992, among the causes of death of urban and rural population in my country, stroke ranked second, accounting for 21.13% and 16.18% of the total number of deaths. The proportion of ischemic...

Claims

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Application Information

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IPC IPC(8): A61K31/18A61P9/10
Inventor 金鑫杨立朝周宇周灏郭涵
Owner XIAMEN UNIV
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