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Class of compounds for treating ischemic brain damage and purpose thereof

A technology of ischemic brain injury and compounds, applied in organic chemistry, drug combination, cardiovascular system diseases, etc., can solve problems such as poor effect, failure to take effect in time, and disability of patients

Inactive Publication Date: 2015-05-20
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs commonly used in clinical treatment of ischemic brain injury, such as antiplatelet drugs, anticoagulant drugs, thrombolytic drugs, defibrinating drugs, and some traditional Chinese medicine treatments, are not effective, and often cannot take effect in time. It's not good, it will cause irreversible disability to the patient, and it will be a lifelong regret
[0005] The inventor unexpectedly discovered that a group of compounds and their analogous compounds or their pharmaceutically acceptable salts have unexpected effects in the preparation of drugs for the treatment of ischemic brain injury, At present, there is no report on the treatment of ischemic brain injury by this class of compounds.

Method used

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  • Class of compounds for treating ischemic brain damage and purpose thereof
  • Class of compounds for treating ischemic brain damage and purpose thereof
  • Class of compounds for treating ischemic brain damage and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] Preparation of lyophilized powder injection containing compound A:

[0035] ① Take mannitol, phospholipids, glycerin, cyclodextrin derivatives, dimethyl sulfoxide and poloxamer, 100mg and 1500mg of the compound of formula (A), mix them in water for injection and dissolve them;

[0036] ② After mixing and dissolving, after stabilization, first use a 0.45um microporous membrane for coarse filtration, and then filter with a 0.2um microporous membrane;

[0037] ③ Divide into small vials, and add other freeze-drying protective agents and auxiliary materials;

[0038] ④ Perform programmed freeze-drying;

[0039] ⑤ Carry out corresponding inspections for pyrogens, sterility, visible foreign matter, insoluble particles, etc., and wait for use after meeting the requirements.

[0040] Preparation of compound B-containing freeze-dried powder injection:

[0041] ⑥ Take mannitol, phospholipids, glycerol, cyclodextrin derivatives, dimethyl sulfoxide and poloxamer, 100mg and...

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Abstract

The invention discloses a class of compounds and pharmaceutical compositions and novel purpose thereof in treating ischemic brain damage. The of above compounds have very significant effects on the treatment of ischemic brain damage.

Description

Technical field [0001] The present invention involves a type of compound that treats ischemic brain damage and its medicinal salt and its analogs.Pharmaceutical salt and analogs are used in the use of drugs that are prepared to treat ischemic brain damage. [0002] Background technique [0003] Ischemic brain injury is a common clinical disease. The disease is characterized by more causes, and there are many drugs in clinical application, but the treatment effect of most drugs is relatively weak.Drugs for blood -based brain injury. [0004] The incidence, disability and mortality of ischemic brain injury in my country are very high. The brain ischemia and hypoxia ischemia ischemic and oxygen necrosis is one of the main diseases that seriously endanger human health. EssenceIschemic brain injury is a complicated pathological process.At present, drugs commonly used in the treatment of ischemic brain injury, such as antiplatelet drugs, anticoagulant drugs, thrombolytic drugs, fibrous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/88C07D403/12C07D513/04C07D401/12C07D403/04A61K31/5377A61K31/497A61P9/10
CPCC07D239/88C07D401/12C07D403/04C07D403/12C07D513/04
Inventor 韩冰张鑫磊
Owner 韩冰
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