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Preparation method of antibacterial polyurethane material capable of promoting growth of tissues

A polyurethane material, tissue growth technology, applied in medical science, surgery, etc., can solve problems such as organ damage

Inactive Publication Date: 2015-05-20
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During recovery after endometrial surgery, oral estrogen is often required to accelerate endometrial growth, but it can also cause damage to other organs in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add dropwise the triethanolamine of 0.1% (weight) in polytetramethylene glycol and butanediol solution, be warming up to 60 ℃, react for 3 hours, stop heating; Add dropwise 0.1% (weight) estrogen and 0.1% ( Weight) reaction type quaternary ammonium salt, keep stirring in the addition process, drip in 30 minutes; Add 1,4-butanediol again, keep stirring, continue to react for 5 hours; Precipitate, wash 3 times with distilled water after filtering, in 10 ℃ for 24 hours, vacuum-dried at 65 ℃ for 48 hours and then molded. The prepared polyurethane material has a Shore hardness of 43.8 and a tensile strength of 5.22 MPa when the tensile elongation is 200%. The antibacterial test is carried out to the material, the inoculated strain is Staphylococcus aureus, and the CFU (colony forming unit) in the culture medium is compared by plate counting method. After 10 days, the CFU (colony forming unit) in the culture medium is 3786 / cm 2 . They were implanted in the uterus of femal...

Embodiment 2

[0016] Add dropwise the triethanolamine of 0.1% (weight) in polytetramethylene glycol and butylene glycol solution, be warming up to 90 ℃, react 4 hours, stop heating; Add dropwise 3% (weight) estrogen and 10% ( Weight) reaction type quaternary ammonium salt, keep stirring in the process of adding, drop in 70 minutes; Add 1,4-butanediol again, keep stirring, continue to react for 4 hours; Precipitate, wash 3 times with distilled water after filtering, in 20 ℃ for 18 hours, vacuum-dried at 50 ℃ for 48 hours and then molded. The prepared polyurethane material has a Shore hardness of 55.6 and a tensile strength of 8.45 MPa when the tensile elongation is 200%. The antibacterial test is carried out to the material, the inoculated strain is Staphylococcus aureus, and the CFU (colony forming unit) in the medium is compared by plate counting method, after 10 days, the CFU (colony forming unit) in the medium is 742 / cm 2 . They were implanted in the uterus of female rabbits who had ...

Embodiment 3

[0018] Add dropwise the triethanolamine of 0.2% (weight) in polytetramethylene glycol and butylene glycol solution, be warming up to 70 ℃, react 6 hours, stop heating; Add dropwise 5% (weight) estrogen and 6% ( Weight) nanometer silver-loaded zirconium phosphate, keep stirring during the addition process, and drop it in 80 minutes; add 1,4-butanediol, keep stirring, and continue to react for 3 hours; wash 4 times with distilled water after precipitation and filtration, ℃ for 12 hours, vacuum-dried at 70 ℃ for 24 hours and then molded. The prepared polyurethane material has a Shore hardness of 52.7 and a tensile strength of 7.08 MPa when the tensile elongation is 200%. The antibacterial test is carried out to the material, the inoculation strain is Staphylococcus aureus, and the CFU (colony forming unit) in the culture medium is compared by plate counting method, after 10 days, the CFU (colony forming unit) in the culture medium is 1408 / cm 2 . They were implanted in the ute...

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Abstract

The invention discloses a preparation method of an antibacterial polyurethane material capable of promoting the growth of tissues. The preparation method comprises the following steps: 1) dripping 0.1-0.3% by weight of triethanolamine into a polytetramethylene glycol and butanediol solution, heating to 60-90 DEG C, reacting for 3-6 hours, and stopping heating; 2) dripping 0.1-10% by weight of estrogen and 0.1-10% by weight of antibacterial agent for 30-90 minutes while stirring continuously; 3) adding 1,4-butanediol, stirring continuously and further reacting for 4-6 hours; and 4) precipitating, filtering, washing with distilled water for 3-5 times, placing for 12-24 hours at 10-30 DEG C, performing vacuum drying for 24-72 hours at 50-70 DEG C and then performing compression molding. By adopting the preparation method, modification can be realized in the polymerization process of polyurethane, and the estrogen and the antibacterial agent form a release system in the polyurethane, so that the polyurethane has the functions of promoting the growth of tissue endomembrane and resisting bacteria.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial polyurethane material capable of promoting tissue growth. Background technique [0002] In our country, due to the special national conditions, there are many patients with artificial abortion and induced labor, and the lag of treatment of gynecological diseases makes the risk of intrauterine adhesions as high as 30%. Intrauterine adhesion is a pathological phenomenon in which part or all of the intrauterine adhesion is formed after the endometrium is damaged. It is one of the common clinical diseases in gynecology. It is clinically manifested as amenorrhea or decreased menstrual flow, periodic abdominal pain and abnormal pregnancy. It can even seriously affect female fertility and lead to infertility. More than 90% of intrauterine adhesions are caused by the destruction of endometrium during surgery, which damages the basal layer of endometrium, resulting in endometrial regenerative di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06
Inventor 刘芳胡琛徐大宝
Owner CENT SOUTH UNIV
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