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Preparation method of multi-antibiotics premix

A technology of multi-antibiotics and premixes, which is applied in the fields of botanical equipment and methods, fungicides, biocides, etc., can solve the problems of poor stability of multi-antibiotic finished products, and achieve convenient storage and application, improved stability, and improved production efficiency. The effect of grain rate and yield improvement

Active Publication Date: 2015-05-20
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of weak stability of multi-antibiotic finished products, the present invention provides a preparation method of multi-antibiotic premix which is simple, low in cost and obviously improves the stability of the obtained product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2140μg / mL) and heat it to 60°C, keep it for 5min, cool down, adjust the pH to 2.5 with hydrochloric acid, add 1.5% of the mass of the fermentation broth Copper sulfate is used as a stabilizer, and 0.2% Toween80 of the fermentation broth is used as an auxiliary agent.

[0024] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), control the pressure filtration pressure to be 1.0MPa, and the pressure filtration time is 2h, obtain the multi-antibiotic wet filter cake of water quality 30% 174kg. (3) Flash drying and pulverization: flash drying the wet filter cake obtained in step (2), controlling the inlet air temperature to 110°C, the outlet air temperature to 65°C, and the material temperature to 85°C to obtain multi-antibiotic mycelium after drying Dry product 52.2kg. The we...

Embodiment 2

[0028] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2340μg / mL) and heat it to 65°C, keep it for 7min, cool, adjust the pH to 3.0 with phosphoric acid, add 2.0% of the mass of the fermentation broth Aluminum sulfate is used as a stabilizer, and 0.25% Span 60 of the fermentation broth is used as an auxiliary agent.

[0029] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), control the pressure filtration pressure to be 2.0MPa, and the pressure filtration time is 1.5h, obtain the water quality 34% multi-antibiotic wet filter cake 156kg.

[0030] (3) Flash drying and crushing: The wet filter cake obtained in step (2) is flash dried, the air inlet temperature is controlled to be 120°C, the air outlet temperature is 70°C, and the material temperature is 95°C. After drying, multi-antibiotic mycelium is obtained Dry product 52kg. ...

Embodiment 3

[0035] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2250μg / mL) and heat it to 70°C, keep it for 10min, cool down, adjust the pH to 4.0 with citric acid, add 3.0% of the fermentation broth mass Aluminum chloride is used as a stabilizer, and 0.3% polysorbate 60 of the fermentation broth is used as an auxiliary agent.

[0036] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), the control pressure filtration pressure is 4.5MPa, and the pressure filtration time is 2h, obtains water quality 40% multi-antibiotic wet filter cake 125kg .

[0037](3) Flash drying and crushing: The wet filter cake obtained in step (2) is flash dried, the air inlet temperature is controlled to be 130°C, the air outlet temperature is 60°C, and the material temperature is 100°C, and multi-antibiotic mycelium is obtained after drying Dry product 50kg. T...

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Abstract

The invention discloses a preparation method of multi-antibiotics premix. The method comprises the steps of heating fermented multi-antibiotics fermentation liquor up to 60-70 DEG C, and maintaining for 5-10 minutes; cooling, adjusting the pH to 2.5-5.0 by acid, feeding a stabilizing agent and an auxiliary agent, fully stirring, and carrying out plate-frame filtering on the fermented liquor to obtain a multi-antibiotics wet filter cake; then, carrying out flash drying on the filter cake, grinding, feeding auxiliary materials and diluting to obtain the multi-antibiotics premix. The preparation method of the multi-antibiotics premix is simple and easy to operate and low in cost; the stability of the obtained multi-antibiotics premix finished product is obviously improved in the storage process, so that the multi-antibiotics premix is more convenient and stable in the processes of storage, transportation and application.

Description

Technical field: [0001] The invention relates to a preparation method of a multi-antibiotic premix, in particular to a preparation method of a multi-antibiotic premix. Background technique: [0002] Polyoxins, also known as polyoxin, polyoxin, and pleiotropin, are broad-spectrum agricultural antibiotics of peptide pyrimidine nucleosides produced by modern bioengineering technology. Multi-antibiotics have systemic and therapeutic effects and high target biological selectivity, and they can specifically act on common fungal diseases of various crops. The most prominent multi-antibiotic is that it has a strong inhibitory effect on 25 kinds of fungal diseases such as flagella, ascomycetes, and half fungi. Studies have shown that pleiotropin consists of 14 components from A to N. Since 1967, pleiotropin has been widely used as an agricultural fungicide to treat rice sheath blight, tomato gray mold and pear black spot. and other plant fungal diseases. [0003] Pleiotropin has a...

Claims

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Application Information

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IPC IPC(8): A01N47/12A01N25/12A01P3/00
CPCA01N25/12A01N47/12
Inventor 胡永红曹翠翠杨文革杨洋殷晶晶
Owner NANJING UNIV OF TECH
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