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Synergist for improving gram-positive-bacterium-resistant effect of nisin

A technology of gram-positive bacteria and nisin, applied in the field of biomedicine

Inactive Publication Date: 2015-05-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the rapid increase and popularization of the application of nisin, nisin may produce corresponding drug-resistant strains in nature like antibiotics, thus affecting and limiting the use of nisin

Method used

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  • Synergist for improving gram-positive-bacterium-resistant effect of nisin
  • Synergist for improving gram-positive-bacterium-resistant effect of nisin
  • Synergist for improving gram-positive-bacterium-resistant effect of nisin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016]

[0017] Example 2

Embodiment 2

[0019] FICI = FIC A +FIC B = C A comb / Mic A alone +C B comb / Mic B alone

[0020] Among them, MIC A alone And MIC B alone The MIC values when the compound A and B are used in single, C A comb C B comb When the two drugs are used to achieve the same efficiency (equivalent point), their respective concentrations.The judgment standards of the FICI value are as follows: FICI ≤ 0.5, indicating that there is a synergistic role between the two compounds; 0.5 4 indicates that there is an antagonistic effect between the two compounds.The results are shown in Table 3 and 4.

[0021]

[0022]

[0023] Result description:

[0024] Table 1: Through Table 1, it can be seen that when the two are combined, it has a significant reduction in MIC values on Staphylococcus aureus.

[0025] Table 2: Through Table 2, it can be seen that when the two are combined, it has a significant reduction in the MIC value of Shanli Lisnem.

[0026] Table 3: Through Table 3, it can be seen that when t...

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Abstract

The invention discloses a synergist for improving the gram-positive-bacterium-resistant effect of nisin. Microdilution method drug susceptibility tests and chessboard type microdilution tests are used, tested bacteria comprise nine staphylococcus aureus food isolated strains, nine listeria monocytogenes food isolated strains and two quality-control strains for contrast, that is, staphylococcus aureus ATCC 29213 and listeria monocytogenes ATCC 19115, the effect caused by perilla oil on the antibacterial activity of the nisin is measured, and test results prove that the perilla oil has the effect of enhancing the gram-positive-bacterium-resistant activity of the nisin. The nisin is a polypeptide antibiotic substance extracted from a streptococcus lactis fermentation product, can be degraded by some proteases in human body digestive tracts easily, and has no adverse effect on colors, aromas, tastes and the like of food, and perilla is rich in alpha-linolenic acid and has effects of resisting oxidation, resisting ageing, resisting thrombus, preventing and treating cardiovascular diseases, resisting cancers, resisting allergies and resisting inflammations. High-nisin and the perilla oil are used as food preservatives, the additive amount of the high-nisin can be decreased, safe and reliable purposes can be achieved, and the health-care effect can be realized.

Description

Technical field [0001] The present invention is the field of biomedicine, which involves an efficient agent and a food anticorrosive additive that improves the role of nicotin anti -Gram -positive bacteria. Background technique [0002] Single Liszt bacteria and Golden Pyrobacteria are a pathogenic bacteria that are common in humans and animals, and the existence of Gram -positive bacteria in nature.After the livestock infection is increased, Liste bacteria is increased, and the food chain finally causes human infection; after human infection can cause gastrointestinalitis, sepsis, meningitis, abortion, it can be more likely to occur for pregnant women, babies, elderly and low immunity.EssenceStaphylococcus aureus has the characteristics of wide distribution, strong pathogenicity, high infection rate and high mortality rate, which can cause a series of complex clinical symptoms such as skin infection to severe sepsis.Food poisoning caused by staphylococci is a global public healt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L3/3472A23L3/3463
Inventor 郭娜赵星辰孟日增李晓旭赵梓雯于录刘宗慧朱宣直
Owner JILIN UNIV
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