Pincer-like Zn(II) metal organic complex, preparation method and application of pincer-like Zn(II) metal organic complex to visual recognition of triphosadenine

A metal-organic and complex technology, which is applied in the direction of zinc-organic compounds, through chemical reaction of materials, and material analysis through observation of the influence of chemical indicators, can solve problems that are not simple, direct, fast, and effective. Accurate identification of adenosine triphosphate, cumbersome detection steps and other issues

Inactive Publication Date: 2015-04-29
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods require the use of sophisticated large-scale instruments and cumbersome detection steps
In addition, there

Method used

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  • Pincer-like Zn(II) metal organic complex, preparation method and application of pincer-like Zn(II) metal organic complex to visual recognition of triphosadenine
  • Pincer-like Zn(II) metal organic complex, preparation method and application of pincer-like Zn(II) metal organic complex to visual recognition of triphosadenine
  • Pincer-like Zn(II) metal organic complex, preparation method and application of pincer-like Zn(II) metal organic complex to visual recognition of triphosadenine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Pincer Zn (II) metal organic complexes 1 Preparation of:

[0022] In a 250 mL round bottom flask, add terpyridine S1 (2.993 g, 10 mmol), zinc nitrate hexahydrate (3.57 g, 12 mmol) and anhydrous methanol. The reaction was stirred at room temperature for 24 hours, a white solid formed in the reaction system, the white solid was obtained by filtration, washed 3 times with anhydrous methanol, and dried in vacuo to obtain 3.91 g of the corresponding pincer Zn(II) metal organic complex 1 . The yield was 80%.

[0023] High resolution mass spectrometry (HR-MS, ESI): m / z 425.0228 (calcd, [M-NO 3 ] + ); 425.0223 (found, [M-NO 3 ] + ).

Embodiment 2

[0024] Example 2: Using pincer Zn(II) organometallic complexes 1 It is mixed with 0.25 times molar equivalent of adenosine triphosphate in water, and the routine operation of heating and cooling gel preparation forms a two-component metal hydrogel to form a visual recognition of adenosine triphosphate with the naked eye:

[0025] In a 5 mL white vial, sequentially add 20 mg pincer Zn(II) organometallic complex 1 , 1 mL of water, sealed with a polyvinyl fluoride cap, and heated the vial with a heat gun. When the solution inside becomes transparent, the pincer Zn(II) metal organic complex 1 Dissolve completely, turn off heating, and let the vial stand for a while. It was observed that a white precipitate was formed in the sample bottle, and no metal hydrogel was formed. Add the metal-organic complex with pincer Zn(II) to the vial again 1 0.25 times the molar equivalent of adenosine triphosphate, sealed again with a polyvinyl fluoride cap, and heated the sample vial with a h...

Embodiment 3

[0026] Example 3: Using pincer Zn(II) organometallic complexes 1 Mixing with 0.25 times the molar equivalent of adenosine diphosphate in water, the conventional operation of gel preparation by heating and cooling, the situation of forming a precipitate:

[0027] In a 5 mL white vial, sequentially add 20 mg pincer Zn(II) organometallic complex 1 , 1 mL of water, sealed with a polyvinyl fluoride cap, and heated the vial with a heat gun. When the solution inside becomes transparent, the pincer Zn(II) metal organic complex 1 Dissolve completely, turn off heating, and let the vial stand for a while. It was observed that a white precipitate was formed in the sample bottle, and no metal hydrogel was formed. Add the metal-organic complex with pincer Zn(II) to the vial again 1 0.25 times the molar equivalent of adenosine diphosphate, sealed again with a polyvinyl fluoride cap, and heated the sample vial with a heat gun. When the solution inside becomes clear, turn off the heat and...

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Abstract

The invention belongs to the technical field of application of visual recognition of small biological molecules, and particularly relates to preparation of a novel pincer-like Zn(II) metal organic complex and application of the pincer-like Zn(II) metal organic complex to naked-eye visual recognition of triphosadenine. The expression of the pincer-like Zn(II) metal organic complex is NNN-Zn-(NO3)2, wherein NNN represents a terpyridyl ligand coordinated with Zn. Under a simple operation (heating/cooling) condition, when the pincer-like Zn(II) metal organic complex 1 is mixed with 0.25 molar equivalent of triphosadenine in water, a kind of two-component metal hydrogel can be formed through the conventional get preparation operations of heating and cooling. While when the pincer-like Zn(II) metal organic complex 1 is mixed with 0.25 molar equivalent of adenosine diphosphate and adenosine monophosphate in water, no metal hydrogel but sediments can be generated through the conventional gel preparation operations such as heating and cooling. The invention develops a fast, simple and convenient new method for naked-eye visual recognition of triphosadenine for the first time.

Description

technical field [0001] The invention belongs to the technical field of visual recognition of biological small molecules, and specifically relates to the preparation of a novel pincer-type Zn (II) metal-organic complex and its realization of adenosine triphosphate naked eye based on the selective formation of a two-component gel. A new approach to visual identification. When the pincer-type Zn(II) metal-organic complex is mixed with adenosine triphosphate in water, a stable two-component metal hydrogel can be easily prepared by the conventional operation of gel preparation with heating and cooling; and adenosine diphosphate (ADP) And adenosine monophosphate (AMP) can not form a stable gel with Zn compounds, therefore, a new method for the naked eye visual recognition of adenosine triphosphate was developed. Background technique [0002] Adenosine triphosphate, namely adenosine triphosphate (ATP), is a high-energy phosphate compound, which realizes the process of energy stora...

Claims

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Application Information

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IPC IPC(8): C07F3/06G01N21/82
Inventor 涂涛刘丛房微魏陆正未
Owner FUDAN UNIV
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