Preparation method of pharmaceutical composition Xianyu for treating epileptoid convulsions, infantile convulsions and facial spasms

A technology for pediatric convulsion and hemifacial spasm, which is applied in the field of pharmaceutical compositions for treating epilepsy convulsions and facial spasms in children, can solve the problems of deterioration of filtration effect, shortened filter membrane life, decreased membrane flux, etc. Membrane concentration effect, improve production efficiency, prolong membrane life effect

Active Publication Date: 2015-04-29
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex composition of traditional Chinese medicine, it is easy to pollute the membrane material; especially in the case of low speed and high solute concentration, when the surface of the membrane reaches or exceeds the saturation concentration of the solute, a gel layer will form, resulting in a decrease in the flux of the membrane. , Filtration effect deteriorates, filter membrane life is shortened, filter membrane cleaning is difficult, which seriously affects the work efficiency and economic benefits of separation and purification

Method used

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  • Preparation method of pharmaceutical composition Xianyu for treating epileptoid convulsions, infantile convulsions and facial spasms
  • Preparation method of pharmaceutical composition Xianyu for treating epileptoid convulsions, infantile convulsions and facial spasms
  • Preparation method of pharmaceutical composition Xianyu for treating epileptoid convulsions, infantile convulsions and facial spasms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Example 1 A capsule for the treatment of epileptic convulsions, infantile convulsions, and hemifacial spasms (Xianyu Capsules)

[0102] Weigh the API according to the following weight (unit: gram)

[0103] Gastrodia elata 105, Uncaria 105, Silkworm 105, Astragalus 140, Codonopsis 140, Salvia miltiorrhiza 140, Bupleurum 70, Suanzaoren 105, Polygala 70, Shichangpu 70, Dannanxing 70, Angelica 140, Curcuma 70, Aconite 35 , Six Divine Comedy 70, Licorice 70.

[0104] Prepared by the following steps:

[0105] (1) Grind 105 grams of silkworm and 70 grams of Liushenqu, pass through a 60-mesh sieve to obtain fine powder, and set aside;

[0106] (2) Put other medicinal materials except silkworm and Liushenqu into the extraction container, add water and decoct three times; add 10 times the weight of the medicinal materials for decoction for 2 hours for the first time, and add 8 times the weight of the medicinal materials for the second time Decoct in water for 1 hour, add w...

Embodiment 2

[0111] Example 2 A pharmaceutical composition capsule (Xianyu Capsule) for treating epileptic convulsions, infantile convulsions, and hemifacial spasm

[0112] Weigh the API according to the following weight (unit: gram)

[0113] Gastrodia 90, Uncaria 90, Silkworm 90, Astragalus 120, Codonopsis 120, Salvia 120, Bupleurum 60, Suanzaoren 90, Polygala 60, Shichangpu 60, Dannanxing 60, Angelica 120, Curcuma 60, Radix Aconiti 30 , Six Divine Comedy 60.

[0114] Prepared by the following steps:

[0115] (1) Grind 90 grams of silkworm and 60 grams of Liushenqu, pass through a 60-mesh sieve to obtain fine powder, and set aside;

[0116] (2) Put other medicinal materials except silkworm and Liushenqu into the extraction container, add water and decoct three times; add 8 times the weight of medicinal materials for decoction for 3 hours for the first time, pour out the decoction liquid; Decoct in water 10 times the weight of the medicine for 3 hours, pour out the decoction; add wa...

Embodiment 3

[0121] Example 3 A pharmaceutical composition capsule (Xianyu Capsule) for treating epileptic convulsions, infantile convulsions, and hemifacial spasm

[0122] Weigh the API according to the following weight (unit: gram)

[0123] Gastrodia 120, Uncaria 120, Silkworm 120, Astragalus 150, Codonopsis 150, Salvia 150, Bupleurum 90, Suanzaoren 120, Polygala 90, Shichangpu 90, Dannanxing 90, Angelica 150, Curcuma 90, Radix Aconiti 40 .

[0124] Prepared by the following steps:

[0125] (1) Grind 120 grams of silkworm, pass through a 60-mesh sieve to obtain silkworm fine powder, and set aside;

[0126] (2) Put other medicinal materials except silkworm and borneol into the extraction container, add water and decoct three times; add 10 times the weight of the medicinal materials for decoction for 1 hour for the first time, and add water 8 times the weight of the medicinal materials for the second time Decoct for 2 hours, add water 6 times the weight of the drug for the third tim...

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PUM

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Abstract

The invention provides a novel preparation method of pharmaceutical composition Xianyu for treating epileptoid convulsions, infantile convulsions and facial spasms. According to the method, a water decoction of medicinal materials is concentrated through a reverse osmosis membrane, and meanwhile, the membrane separation effect is enhanced through ultrasonic coupling. With the adoption of the method, the concentration efficiency is greatly improved, the energy consumption is reduced, the working time is shortened, and meanwhile, the service life of the reverse osmosis membrane is prolonged. The invention further provides the pharmaceutical composition prepared with the preparation method. The pharmaceutical composition comprises capsules, tablets and granules.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a method for preparing a pharmaceutical composition for treating epileptic convulsions, convulsions in children, and facial convulsions by using ultrasonic-enhanced membrane separation technology. Background technique [0002] The extracts of Chinese herbal medicines are large in volume and complex in composition. Therefore, the concentration of Chinese medicinal material extract is a key step related to the quality of the preparation and the energy consumption of production. [0003] Xianyu Capsule is a traditional Chinese medicine capsule for the treatment of epilepsy. At present, the method of combining water extraction and alcohol extraction followed by atmospheric pressure evaporation concentration or reduced pressure concentration is used. The publication number is CN1785409A, and the invention patent application titled "a drug for treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/08A61P21/02A61K35/64
Inventor 胡小虎刘锐赵宗平
Owner XIAN CHIHO PHARMA
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