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Antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang as well as preparation method and application thereof

A technology for warming and tonifying kidney-yang and a composition is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve problems such as unstable curative effect, and achieve the effects of simple composition, strengthening kidney and strengthening yang, and invigorating spirits.

Active Publication Date: 2015-04-29
浙江省中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, there are two outstanding problems: one is that the theory of traditional Chinese medicine on depression needs breakthroughs and innovations
According to the commonality of the pathogenesis of depression and stagnation of liver qi, traditional Chinese medicine often assists in the treatment of liver qi stagnation and relieving depression. Therefore, prescriptions and medicines can achieve certain curative effects in clinical practice, but the curative effects are often unstable

Method used

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  • Antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang as well as preparation method and application thereof
  • Antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang as well as preparation method and application thereof
  • Antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Toxicity comparison of different prescriptions of Epimedium curculigo and Epimedium curculigo and the correlation between toxicity and content

[0031] Curculigo is a special medicine for warming the kidney and tonifying yang. Epimedium can also benefit the essence, qi and tonify the kidney and yang. The two medicines are compatible and must be used for each other. They complement each other. Ancient and modern records of the nature and flavor of curculigo are pungent or sweet, warm or hot, and poisonous. Theoretically speaking, the combination of "two immortals" may produce synergistic effect and detoxification, but whether it can indeed synergize and detoxify, and the compatibility ratio of synergistic effect and detoxification, the correlation with the content of ingredients, and the pharmacological mechanism need to be clarified. The following research focuses on the determination and comparison of the toxicity of Erxianyao to the water extracts and ethano...

Embodiment 2

[0064] Example 2 Comparative study on the effect of nourishing kidney yang between different compatible prescriptions of Curculigo and Epimedium and the original prescription of Erxian Decoction

[0065] Erxian Decoction is a traditional Chinese medicine compound created by the famous doctor Zhang Berna in the 1950s. Erxian Decoction warms and invigorates kidney yang, nourishes blood and replenishes qi, and is mainly used for menopausal syndrome. Chinese medicine believes that menopausal syndrome is mainly caused by kidney deficiency, and Curculigo-Epimedium is the two king herbs in "Erxian Decoction". For the effect of Qi and kidney yang, traditional Chinese medicine often combines the two with 1׃1. Our previous studies have shown that the combination of the two can reduce the poison of curculigo, but whether it can enhance the effect of tonifying kidney yang and the optimal combination of synergistic and attenuating toxicity remains to be further explored. In this experime...

Embodiment 3

[0153] Example 3 Comparison of Antidepressant Effects of Curculigo and Epimedium Huo with Different Compatibility Prescriptions and Erxian Decoction

[0154] Depression refers to psychological disorders caused by various reasons. It is a common and frequently-occurring disease that seriously endangers human physical and mental health. Currently, there is a lack of highly effective and low-toxic drugs for the treatment of depression. Curculigo curculigo and Epimedium (also known as Xianlingpi) are a well-known Chinese medicine pair called "Erxian", and they are also the two main ingredients in "Erxian Decoction" in traditional Chinese medicine. Studies have shown that Curculigo curculigo has antidepressant effect; its antidepressant material basis is phenolic components such as curculin and orcinol glucoside; the same Epimedium extract also has certain antidepressant effect, and its antidepressant effect is similar to that of Nerve cell protection. However, there is no relevant...

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Abstract

The invention discloses an antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang as well as a preparation method and application thereof. The traditional Chinese medicine composition mainly comprises a plurality of parts by weight of curculigo rhizome and a plurality of parts by weight of herb of korean epimedium in a weight ratio of (1:1.5)-(1:3.0). The antidepressant traditional Chinese medicine composition also comprises a pharmaceutically acceptable auxiliary material. A dressing or an excipient comprises a solvent, a disintegrating agent, a correctant, a preservative and a colorant. The antidepressant traditional Chinese medicine composition can be prepared into clinically acceptable dosage forms including tablets, capsules, pills, particles, suspension agents, drop pills, oral liquid preparations, injections, aerosols and suppositories. The preparation method of the antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang comprises a step of adopting water extraction or alcohol extraction preferably water extraction. The antidepressant traditional Chinese medicine composition for warmly invigorating kidney yang can be used for preventing or treating depression, and is suitable for depression patients with yang energy closing, yang depression mental deterioration, low spirit, slow thinking, laziness in speaking an less movement and sagged spirits.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for warming and tonifying kidney yang and antidepressant, as well as its preparation method and application. technical background [0002] Depression is a common and frequently-occurring disease that seriously endangers human physical and mental health, and is one of the major diseases that endanger human health in the new century. At present, the mechanism of action of western antidepressants is mostly related to the reabsorption or metabolic inhibition of monoamine transmitters, and there are obvious toxic and side effects; in fact, the clinical symptoms of depression are diverse, and the antidepressant spectrum of existing western medicine is relatively narrow; for depression However, no ideal drug has been developed so far. Compared with Western medicine, Chinese herbal medicine has the advantages of less side effects an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P25/24A61K36/296
Inventor 杨明华陈婉姬
Owner 浙江省中药研究所有限公司
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