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Use of rhodiola root and spine date seed compound polysaccharide in preparation of anti neurodegenerative disease health food

A technology of neurodegenerative and rhodiola rosea polysaccharides, which is applied in the fields of application, food preparation, food science, etc., can solve the problems of limited action targets, insufficient activity and function, etc., and is suitable for large-scale production, and the preparation process is simple and efficient, and promotes Effects of in-depth application and modernization of traditional Chinese medicine

Inactive Publication Date: 2015-04-22
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the occurrence and development of neurodegenerative diseases are multifactorial and complex, a single polysaccharide may have problems such as limited targets and insufficient activity and function. Therefore, expanding and enhancing the activity of polysaccharides is necessary for the in-depth development and improvement of polysaccharide products. indispensable

Method used

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  • Use of rhodiola root and spine date seed compound polysaccharide in preparation of anti neurodegenerative disease health food
  • Use of rhodiola root and spine date seed compound polysaccharide in preparation of anti neurodegenerative disease health food
  • Use of rhodiola root and spine date seed compound polysaccharide in preparation of anti neurodegenerative disease health food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]A compound polysaccharide of Rhodiola rosea and Semen jujubee provided in this example is prepared by the following method: mixing Rhodiola rosea and Semen jujubee according to the weight ratio of 1:1, wherein Rhodiola means Rhodiola rosea The rhizome of the medicinal part, the jujube seed refers to the seed of the medicinal part of the jujube, the same below, after crushing, add water according to the ratio of solid to liquid 1:10 (g / mL), heat and stir at 90°C for 4 hours. Add water to the medicinal dregs obtained by filtration according to the solid-liquid ratio of 1:5 (g / mL), and continue to extract at 90°C for 4 hours. Combine the two extracts, concentrate under reduced pressure and centrifuge to obtain a clear concentrated solution, add 4 times the volume of 95% (volume percentage, the same below) ethanol to the concentrated solution according to the volume ratio of 1:4, mix well and store at 4°C The precipitate was left to stand overnight, and the precipitate was c...

Embodiment 2

[0037] A compound polysaccharide of rhodiola rosea and wild jujube kernels provided in this example is prepared by the following method: mixing rhodiola rosea and wild jujube kernels according to the weight ratio of 2:3, and pulverizing them according to the material-to-liquid ratio of 1:15 ( g / mL) with water, heated and stirred at 90°C for 6h. Concentrate under reduced pressure and centrifuge to obtain a clarified concentrated solution. Add 3 times the volume of 95% ethanol to the concentrated solution according to the volume ratio of 1:3, mix well and let it stand overnight at 4°C for precipitation, collect the precipitate by centrifugation, and vacuum freeze-dry to obtain Complex polysaccharides.

[0038] In this embodiment, as in Example 1, rhodiola rosea or jujube seed can be used as raw materials to prepare rhodiola rosea and jujube seed compound polysaccharide.

Embodiment 3

[0040] A compound polysaccharide of rhodiola rosea and wild jujube kernel provided in this example is prepared by the following method: mixing rhodiola rosea and wild jujube kernel medicinal materials according to a weight ratio of 3:2, and after crushing, according to a material-to-liquid ratio of 1:10 ( g / mL) with water, heated and stirred at 95°C for 3h. The medicinal dregs obtained by filtering are continuously extracted once according to the above-mentioned solid-liquid ratio, temperature and time. Combine the two extracts, concentrate under reduced pressure and centrifuge to obtain a clear concentrated solution, add 2 times the volume of 95% ethanol to the concentrated solution according to the volume ratio of 1:2, mix well and let it stand overnight at 4°C for precipitation, and collect the precipitate by centrifugation , the complex polysaccharide can be obtained after vacuum freeze-drying.

[0041] In this embodiment, as in Example 1, rhodiola rosea or jujube seed ca...

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Abstract

The present invention discloses use of rhodiola root and spine date seed compound polysaccharide in preparation of anti neurodegenerative disease health food, the compound polysaccharide is a composition of rhodiola root polysaccharide and spine date seed polysaccharide, the compound polysaccharide is prepared from rhodiola root and / or spine date seed as raw materials by water extraction, concentration and alcohol precipitation process, the preparation method is simple, stable, efficient, and suitable for industrial production. By caenorhabditis elegans model experiment verification, the rhodiola root and spine date seed compound polysaccharide can effectively inhibit neurotoxicity of amyloid beta-protein and polyglutamine, the action mode is related with toxic protein aggregation inhibition, heat shock protein expression increase and reactive oxygen free radical level reduction, and neuroprotective effect can be shown.

Description

technical field [0001] The invention belongs to the technical field of health food / health food, and in particular relates to the application of compound polysaccharides of rhodiola rosea and jujube seed in the preparation of anti-neurodegeneration health food. Background technique [0002] With the aging of the social population, neurodegenerative diseases have become a major disease that seriously endangers people's health and quality of life. Although drugs that relieve symptoms of patients have been marketed, these drugs lack attention to the occurrence and development of the disease . Therefore, it is undoubtedly of great significance to people's livelihood to actively develop health food / health food for neurodegenerative diseases. A variety of known neurodegenerative diseases involve the abnormal aggregation of proteins. For example, the main pathological feature of Alzheimer's disease is the accumulation of extracellular β-amyloid protein (amyloidβprotein; Aβ). The m...

Claims

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Application Information

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IPC IPC(8): A23L1/09A23L33/125
CPCA23L29/30A23V2002/00
Inventor 胡明华马方励梁明
Owner INFINITUS (CHINA) CO LTD
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