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Pharmaceutical use of protopanaxatriol or/and derivatives thereof

A technology of protopanaxatriol and derivatives, which is applied in the field of medicine, can solve the problems of reducing myocardial oxygen consumption enhancement, reducing the contraction and ejection of small viscera in a quiet state, and reducing the infarct size of the brain.

Inactive Publication Date: 2015-04-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xiang Qiuling and others disclosed that PPT saponins can significantly improve the signs of hemiplegia in MCAO rats, reduce the size of infarcts in the brain, and relieve cerebral edema [Journal of Sun Yat-sen University (Medical Science Edition), 2008 (06)]; Xie Yaqi and others disclosed the PPT extracted from American ginseng Saponins can stimulate the function of the adrenal cort

Method used

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  • Pharmaceutical use of protopanaxatriol or/and derivatives thereof
  • Pharmaceutical use of protopanaxatriol or/and derivatives thereof
  • Pharmaceutical use of protopanaxatriol or/and derivatives thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] 1. Drugs and animals

[0031] 8-week-old C57 / BJ6 mice, weighing about 22-25 grams per mouse. The feeding conditions are SPF grade, and the feeding temperature is 22-23°C. 12 hours day and night alternation. Animal feed was purchased from Research Diet (high fat D12492, low fat D12450B).

Embodiment 20

[0032] The following examples use 20(S)-protopanaxatriol monomer compound as the active drug, and its chemical mechanism formula is as follows:

[0033]

[0034] 2. Experimental equipment

[0035] Blood glucose meters and test strips were purchased from Roche (Full Health).

[0036] 3. Animals and Grouping

[0037]The 8-week-old mice were fed with feed containing 60% (w / w) fat, and the treatment group mixed the medicine into the feed, and the mice had free access to food and water. A total of 8 weeks of treatment. The body weight and food intake of the mice were recorded every other day.

[0038] 4. Effect of protopanaxatriol on body weight of obese mice

[0039] After the C57BJ / 6 mice were fed with high-fat diet (Research Diet, D12492) for 3 months, the obese mice were fed with protopanaxatriol (administration concentration: 0.1wt%), administered continuously for 4 weeks, and measured every week Mouse body weight once.

[0040] figure 1 Shows the effect of protopana...

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PUM

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Abstract

The invention discloses a pharmaceutical use of protopanaxatriol or/and derivatives thereof as active ingredient(s) for preparing medicines for treating fatty liver. Research results show that the protopanaxatriol has an obvious in-vitro effect of inhibiting fat cell differentiation and also has the in-vivo effects of preventing the weight increase of high-fat meal induced fat rats, inhibiting the volume increase of body fat cells, improving fasting blood-glucose, insulin resistance and dyslipidemia and the like; in addition, PPAR gamma report gene analysis results indicate that the protopanaxatriol is capable of selectively inhibiting the transcriptional activity of PPAR gamma. In other words, the protopanaxatriol has remarkable treatment activity on the fatty liver, and also is capable of achieving the effect of preventing, improving and/or treating metabolic diseases such as obesity by selectively inhibiting the transcriptional activity of PPAR gamma, and has a remarkable pharmaceutical value especially for obesity patients suffering from fatty liver.

Description

technical field [0001] The invention relates to a medicinal use of protopanaxatriol or / and its derivatives, and belongs to the technical field of medicine. Background technique [0002] Fatty liver refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. Fatty liver disease is a serious threat to the health of Chinese people, becoming the second largest liver disease next to viral hepatitis, and has been recognized as a common cause of hidden liver cirrhosis. Fatty liver clinical manifestations are asymptomatic in mild cases, and severe in severe cases. Generally speaking, fatty liver is a reversible disease, early diagnosis and timely treatment can often return to normal. [0003] The incidence of fatty liver has risen rapidly in Europe, America and my country in recent years. 25%; the incidence rate of fatty liver in obese people and type II diabetes patients is 50%; the incidence rate of fatty liver in alcoholics ...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P1/16A61P3/04A61P5/50A61P3/06
CPCA61K31/575
Inventor 黄诚季光张玉
Owner SHANGHAI UNIV OF T C M
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