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Bioactive and degradable coral hydroxyapatite artificial bone

A coral hydroxyapatite and artificial bone technology, which is applied in the field of medical biomaterials, can solve the problems of poor osteoinductive activity and unsatisfactory degradability of artificial bone, and achieves low cost and sufficient, good osteoconductive activity and good pore structure. Effect

Active Publication Date: 2017-05-03
筴文奎 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the defects of unsatisfactory degradability and poor osteoinductive activity of the existing artificial bone, the present invention provides a bioactive degradable coral hydroxyapatite artificial bone and its preparation method

Method used

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  • Bioactive and degradable coral hydroxyapatite artificial bone
  • Bioactive and degradable coral hydroxyapatite artificial bone
  • Bioactive and degradable coral hydroxyapatite artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] The present invention provides a bioactive degradable coral hydroxyapatite artificial bone. The artificial bone includes a bracket, and the bracket is attached with osteoinducing active cytokines and slow-release agents; the bracket includes a bracket body, and the bracket body is Coral, the surface of the support body is covered with a layer of hydroxyapatite; the osteoinductive cytokine is recombinant human bone morphogenic protein-2 mature peptide; the slow-release agent is a combination of collagen and fibronectin, collagen and fibronectin The mass ratio is 1:1.

[0071] The amino acid sequence of the recombinant human bone morphogenic protein-2 mature peptide is as follows:

[0072] KRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR (see SEQ ID NO: 1).

[0073] The artificial bone is granular, with a diameter of 2-6 mm, the diameter of the micropores is 77-180 μm, and the porosity of the micropores is 8%-11%...

Embodiment 2

[0080] The present invention provides a bioactive degradable coral hydroxyapatite artificial bone. The artificial bone includes a bracket, and the bracket is attached with osteoinducing active cytokines and slow-release agents; the bracket includes a bracket body, and the bracket body is Coral, the surface of the support body is covered with a layer of hydroxyapatite; the osteoinductive cytokine is recombinant human bone morphogenic protein-2 mature peptide; the slow-release agent is selected from the combination of collagen and hyaluronic acid, collagen and hyaluronic acid The mass ratio of acid is 1:1.

[0081]The amino acid sequence of the recombinant human bone morphogenic protein-2 mature peptide is as follows:

[0082] KRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR. (see sequence 1)

[0083] The support is granular, with a diameter of 5-6 mm, the diameter of the micropores is 77-180 μm, and the porosity of th...

Embodiment 3

[0089] The present invention provides a bioactive degradable coral hydroxyapatite artificial bone. The artificial bone includes a bracket, and the bracket is attached with osteoinducing active cytokines and slow-release agents; the bracket includes a bracket body, and the bracket body is Coral, the surface of the bracket body is covered with a hydroxyapatite layer; the osteoinducing cytokine is recombinant human bone morphogenic protein-2 mature peptide; the slow-release agent is a combination of hyaluronic acid and polyvinylpyrrolidone, hyaluronic acid The mass ratio to polyvinylpyrrolidone is 1:1.

[0090] The amino acid sequence of the recombinant human bone morphogenic protein-2 mature peptide is as follows:

[0091] KRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR. (see sequence 1)

[0092] The artificial bone is granular, with a diameter of 4-6 mm, the diameter of the micropores is 77-180 μm, and the porosity o...

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Abstract

The invention relates to the technical field of medical biological materials, in particular to a bioactive degradable coral hydroxyapatite artificial bone and a preparation method thereof. The artificial bone comprises a bracket, wherein bone-inducing active cell factors and controlled release formulations are attached onto the bracket; the bracket comprises a bracket body; the bracket body is coral; a hydroxyapatite layer coats the surface of the bracket body; the bone-inducing active cell factors are made of recombinant human bone morphogenetic protein-2 mature peptide; the controlled release formulations are selected from collagen, fibronectin, hyaluronic acid and the like; the bracket is granular or cylindrical; the aperture range of micropores is 77-180 microns; the porosity of the micropores is 8-11%. According to verification results of the National Institute for the Control of Pharmaceutical and Biological Products (verification report numbers comprise QZ200701428 and QZ200804480) and the National Institutes for Food and Drug control (verification report number is QZ201206312), the artificial bone is excellent bone graft substitute.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a biologically active and degradable coral hydroxyapatite artificial bone and a preparation method thereof. Background technique [0002] Patients with bone defects account for a high proportion of orthopedic patients. These patients cannot repair the defect through the body's own recovery mechanism, so bone transplantation must be performed. [0003] The material used for bone grafting treatment is called artificial bone for short. Artificial bone needs to have suitable size, suitable porosity and pore diameter, and have suitable materials and functions. [0004] An ideal bone graft material needs to have both osteoconductive and osteoinductive activities. Coral and coral-derived hydroxyapatite materials have a pore structure similar to that of human bone, and are widely used as scaffold materials for filling bone defects. Because of their good three-dimensional st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/56A61L27/36A61L27/12
Inventor 筴文奎后力
Owner 筴文奎
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