Hydroxy apatite/zirconia composite bio-ceramic and preparation method thereof

A composite bioceramic and hydroxyapatite technology, applied in dental preparations, tissue regeneration, pharmaceutical formulations, etc.

Inactive Publication Date: 2015-03-11
广东华旺锆材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prepared composite biological material has improved mechanical properties compared with hydroxyapatite biological material, but it is still not ideal, and the density of the material is small. The relationship between graystone is not close, which affects the toughness of the material. Therefore, the performance of the material intervenes between the two, and does not achieve a better improvement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A hydroxyapatite / zirconia composite bioceramic uses hydroxyapatite powder as a matrix material and nano zirconia as a coating material, and the surface of the hydroxyapatite powder is coated with nano zirconia.

[0028] According to the preparation method provided by the present invention, the above-mentioned hydroxyapatite / zirconia composite bioceramic is prepared, and the steps are as follows:

[0029] (1) Preparation of hydroxyapatite powder: CaHPO 4 with CaCO 3 The ratio of the amount of substances is 6:4 for batching; then perform wet ball milling for 24 hours; pour the ball-milled slurry into a container, add distilled water, and stir at a constant temperature of 95°C. After the reaction is completed, place it for precipitation Obtain white hydroxyapatite precipitate, then dry and pass through a 200-mesh sieve;

[0030] (2) Put the hydroxyapatite powder into the chemical vapor deposition reaction chamber to carry out the chemical vapor deposition reaction: use z...

Embodiment 2

[0037] A hydroxyapatite / zirconia composite bioceramic uses hydroxyapatite powder as a matrix material and nano zirconia as a coating material, and the surface of the hydroxyapatite powder is coated with nano zirconia.

[0038] According to the preparation method provided by the present invention, the above-mentioned hydroxyapatite / zirconia composite bioceramic is prepared, and the steps are as follows:

[0039] (1) Preparation of hydroxyapatite powder: CaHPO 4 with CaCO 3 The ratio of the amount of substances is 6:4 for batching; then perform wet ball milling for 24 hours; pour the ball-milled slurry into a container, add distilled water, and stir at a constant temperature of 95°C. After the reaction is completed, place it for precipitation Obtain white hydroxyapatite precipitate, then dry and pass through a 200-mesh sieve;

[0040] (2) Put the hydroxyapatite powder into the chemical vapor deposition reaction chamber to carry out the chemical vapor deposition reaction: use z...

Embodiment 3

[0047] A hydroxyapatite / zirconia composite bioceramic uses hydroxyapatite powder as a matrix material and nano zirconia as a coating material, and the surface of the hydroxyapatite powder is coated with nano zirconia.

[0048] According to the preparation method provided by the present invention, the above-mentioned hydroxyapatite / zirconia composite bioceramic is prepared, and the steps are as follows:

[0049] (1) Preparation of hydroxyapatite powder: CaHPO 4 with CaCO 3 The ratio of the amount of substances is 6:4 for batching; then perform wet ball milling for 24 hours; pour the ball-milled slurry into a container, add distilled water, and stir at a constant temperature of 95°C. After the reaction is completed, place it for precipitation Obtain white hydroxyapatite precipitate, then dry and pass through a 200-mesh sieve;

[0050] (2) Put the hydroxyapatite powder into the chemical vapor deposition reaction chamber to carry out the chemical vapor deposition reaction: use zir...

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Abstract

The invention discloses a hydroxy apatite / zirconia composite bio-ceramic and a preparation method thereof, and relates to the field of biological materials. The hydroxy apatite powder is taken as the basic material, nano zirconia is taken as the cladding material, and the nano zirconia is coated on the surface of the hydroxy apatite surface; wherein the average particle size of the hydroxy apatite powder is 10 to 50 [mu]m, the thickness of the nano zirconia cladding layer is 100 to 300 nm; and the hydroxy apatite powder is prepared through a precipitation reaction method or a hydrothermal method. The preparation method comprises steps of preparing hydroxy apatite powder, carrying out chemical vapor deposition reactions, and performing high temperature solid state method. The provided hydroxy apatite / zirconia composite bio-ceramic has a high mechanical strength and good biocompatibility, can be used to repair or fill tooth or alveolar cavity and repair bone damage, and can also be used as artificial bone cores to treat bone tuberculosis.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a hydroxyapatite / zirconia composite bioceramic and a preparation method of the bioceramic. Background technique [0002] Biomaterials are materials that repair, replace and regenerate body tissues. Due to the dissolution, corrosion and fatigue problems of stainless steel, the problems of poor stability and low strength of plastics exist. Bioceramic materials have been widely developed and have broad application prospects. [0003] Bioceramic materials are divided into bioinert ceramic materials and bioactive ceramic materials. Zirconia bioceramics are bioinert ceramic materials with excellent wear resistance and mechanical strength, and are generally used as tooth restoration or replacement materials; hydroxyapatite bioceramics Belonging to bioactive ceramics, the structure of hydroxyapatite is similar to that of biological bone. Therefore, synthetic hydroxyapatite biocerami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/30A61L27/50A61K6/838
CPCA61K6/818A61K6/838A61L27/10A61L27/12A61L27/306A61L27/50A61L2430/02A61L2430/12C04B35/447C04B35/48C04B35/622C04B35/62823C04B35/62884C04B2235/3244C04B2235/5436C04B2235/5454C04B2235/658C04B2235/96
Inventor 郭玉芹刘乐峰邱东成
Owner 广东华旺锆材料有限公司
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