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Adhesive for soft tissue and preparation method thereof

A technology for adhesive and soft tissue, applied in the field of adhesive for soft tissue and its preparation, can solve the problems of non-appearance of medical adhesive, and achieve the effects of low cost, little stimulation and simple process

Active Publication Date: 2016-07-13
润桐(苏州)技术服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, medical adhesives that can fully meet the ideal requirements have not yet appeared.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An adhesive for soft tissue, comprising the following components in parts by weight: 30 parts of ethyl α-cyanoacrylate, 30 parts of n-butyl α-cyanoacrylate, 30 parts of n-octyl α-cyanoacrylate, 30 parts of ethoxyethyl α-cyanoacrylate, 10 parts of gelatin, 5 parts of chitosan, 0.5 part of hydroquinone, 3 parts of rosin resin, 3 parts of sulfur dioxide and 30 parts of deionized water.

[0028] The preparation method is as follows:

[0029] (1) take each raw material by weight;

[0030] (2) Add α-ethyl cyanoacrylate, α-n-butyl cyanoacrylate, α-n-octyl cyanoacrylate, α-ethoxyethyl cyanoacrylate and other raw materials into the container in sequence, Heat to 60°C, stir until completely dissolved and the solution becomes transparent;

[0031] (3) Uniformly irradiating the transparent solution prepared in step (2) under γ-rays for 46 hours to obtain an adhesive for soft tissue.

Embodiment 2

[0033] An adhesive for soft tissue, comprising the following components in parts by weight: 38 parts of ethyl α-cyanoacrylate, 36 parts of n-butyl α-cyanoacrylate, 38 parts of n-octyl α-cyanoacrylate, 39 parts of ethoxyethyl α-cyanoacrylate, 14 parts of gelatin, 9 parts of chitosan, 0.9 part of hydroquinone, 5 parts of rosin resin, 3 parts of sulfur dioxide and 45 parts of deionized water.

[0034] The preparation method is as follows:

[0035] (1) take each raw material by weight;

[0036] (2) Add α-ethyl cyanoacrylate, α-n-butyl cyanoacrylate, α-n-octyl cyanoacrylate, α-ethoxyethyl cyanoacrylate and other raw materials into the container in sequence, Heat to 65°C, stir until completely dissolved and the solution becomes transparent;

[0037] (3) Uniformly irradiating the transparent solution prepared in step (2) under γ-rays for 48 hours to obtain an adhesive for soft tissue.

Embodiment 3

[0039] An adhesive for soft tissue, comprising the following components in parts by weight: 42 parts of ethyl α-cyanoacrylate, 38 parts of n-butyl α-cyanoacrylate, 40 parts of n-octyl α-cyanoacrylate, 41 parts of ethoxyethyl α-cyanoacrylate, 15 parts of gelatin, 10 parts of chitosan, 1 part of hydroquinone, 6 parts of rosin resin, 4 parts of sulfur dioxide and 46 parts of deionized water.

[0040] The preparation method is as follows:

[0041] (1) take each raw material by weight;

[0042] (2) Add α-ethyl cyanoacrylate, α-n-butyl cyanoacrylate, α-n-octyl cyanoacrylate, α-ethoxyethyl cyanoacrylate and other raw materials into the container in sequence, Heat to 70°C, stir until completely dissolved and the solution is transparent;

[0043] (3) Uniformly irradiating the transparent solution prepared in step (2) under gamma rays for 58 hours to obtain an adhesive for soft tissue.

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PUM

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Abstract

The invention provides an adhesive for soft tissues and a preparation method of the adhesive. The adhesive comprises the following components: alpha-cyanoacrylate, n-butyl-cyanoacrylate, octyl-alpha-cyanoacrylate, ethyl alpha-cyanoacrylate, gelatin, chitosan, hydroquinone, rosin resin, sulfur dioxide and deionized water. The preparation method comprises the following steps: weighing the raw materials in parts by weight; sequentially adding the raw materials into a container, heating to be 60-80 DEG C, and stirring till completely dissolving, wherein the solution is transparent; uniformly irradiating the obtained transparent solution in gamma rays for 36-72 hours to obtain the adhesive for soft tissues. The adhesive for soft tissues is high in bonding strength, the allergy tests of intracutaneous irritation test boxes are qualified, the irritation to organism tissues is small, and the requirement on medical adhesives used in clinical applications is met.

Description

technical field [0001] The invention relates to the field of adhesives, in particular to an adhesive for soft tissue and a preparation method thereof. Background technique [0002] With the advancement of the medical level, the clinical requirements for surgical operations and auxiliary materials are getting higher and higher, and the improvement of clinical requirements has promoted the research and development of medical adhesives. Medical adhesives refer to preparations, materials or substances that can be adhered to surfaces or cause adhesion between surfaces in medical applications. They are mainly used for local adhesion and repair of organs or tissues, auxiliary hemostasis of traditional sutures, Dental repair, bone or joint combination and positioning and other technical fields. Compared with traditional methods such as suturing and stapling, the use of medical adhesives can effectively shorten the operation time and reduce the patient's pain. Therefore, medical ad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/02
Inventor 高宏王栩李苏杨徐勤霞
Owner 润桐(苏州)技术服务有限公司
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