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A method for preparing capsule shells from glycosylated modified zein

A technology of zein and glycosylation, which is applied in the fields of capsule delivery, non-active ingredients of polymer compounds, food science, etc., can solve the problem of high chemical residues, achieve high grafting degree, good effect, and good moisture resistance Effect of Oxygen Properties

Active Publication Date: 2017-10-13
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent adopts a compounding process, and chemical reagents need to be added for edible or medicinal capsule shells, and the chemical residues are high.

Method used

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  • A method for preparing capsule shells from glycosylated modified zein

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Step 1: Take 10 g of zein with a purity of 90%, dissolve it with 80% ethanol solution to obtain a prolamin dispersion, add 35 mL of polyfructose with a concentration of 0.2 g / mL and a purity of 95%, and add ethanol Solution, so that the total system is 100mL, heating and magnetic stirring at 75°C, and preparing a mixed solution for 30min, so that the final concentration of zein is 10%.

[0018] Step 2: Ultrasonic the dispersion liquid at 300W, mix it for 20 minutes, vacuum freeze-dry the uniformly dispersed mixed liquid, and crush it through a 100-mesh sieve after drying.

[0019] Step 3: Place the dry sample powder at 75°C and 80% relative humidity (maintained with saturated KBr solution) to react for 96 hours, wash repeatedly with distilled water, centrifuge to remove residual polyfructose and other impurities, and freeze-dry to obtain modified zein Sample, the degree of grafting of glycosylated products is more than 20%.

[0020] Step 4: Dissolve the modified zein p...

Embodiment 2

[0022] Step 1: Take 9 g of zein with a purity of 90%, dissolve it with 80% ethanol solution to obtain a prolamin dispersion, add 15 mL of polyfructose with a concentration of 0.2 g / mL and a purity of 95%, and add ethanol solution, so that the total system was 100 mL, heated and magnetically stirred at 80°C, and prepared a mixed solution for 30 minutes, so that the final concentration of zein was 9%.

[0023] Step 2: Sonicate the dispersion at 400W, mix for 15 minutes, vacuum freeze-dry the uniformly dispersed mixture, and crush it through a 100-mesh sieve after drying.

[0024] Step 3: Place the dry sample powder at 80°C and 78% relative humidity (maintained with saturated KBr solution) to react for 54 hours, wash repeatedly with distilled water, centrifuge to remove residual polyfructose and other impurities, and freeze-dry to obtain modified zein Sample, the degree of grafting of glycosylated products is more than 20%.

[0025] Step 4: Dissolve the modified zein powder into...

Embodiment 3

[0027] Step 1: Take 10 g of zein with a purity of 90%, dissolve it with 80% ethanol solution to obtain a prolamin dispersion, add 30 mL of polyfructose with a concentration of 0.2 g / mL and a purity of 95%, and add ethanol Solution, make the total system 100mL, heat and magnetically stir at 70°C, and prepare the mixed solution for 30min, so that the final concentration of zein is 10%.

[0028] Step 2: Ultrasonic the dispersion liquid at 400W, mix for 20 minutes, vacuum freeze-dry the uniformly dispersed mixed liquid, and crush through a 100-mesh sieve after drying.

[0029] Step 3: Place the dry sample powder at 70°C and 70% relative humidity (maintained with saturated KBr solution) to react for 180 hours, wash repeatedly with distilled water, centrifuge to remove residual polyfructose and other impurities, and freeze-dry to obtain modified zein Sample, the degree of grafting of glycosylated products is more than 20%.

[0030] Step 4: Dissolve the modified zein powder into an ...

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Abstract

The invention discloses a method for preparing capsule shells from glycosylated modified zein, and belongs to the technical field of processing health food and medical preparation auxiliary materials. The invention uses polyfructose to carry out glycosylation modification on zein, and then uses the modified zein to prepare capsule shells. The zein film itself has good moisture and oxygen resistance properties, coupled with the modified flexibility, the capsule shell with certain elasticity can be prepared without adding harmful organic solvents and plasticizers, avoiding corn The gliadin membrane is brittle and fragile. The invention is all made of food-grade raw materials and has good safety.

Description

technical field [0001] The invention relates to a method for preparing capsule shells from glycosylated modified zein, and belongs to the technical field of processing health food and medical preparation auxiliary materials. technical background [0002] Capsule shell is a commonly used packaging material for health food and medicine. It has the functions of ensuring that the nutrients and flavors of the food are not lost, covering the bad smell of the medicine, and releasing the medicine in a targeted manner. Traditional edible and medicinal capsule shells are fat-free, high-protein, high-grade gelatin products that are easily absorbed by the human body, which are made from animal bones, skins, and hoof tissues through complex physical and chemical treatments. Problems, such as capsules are easy to lose water and harden, absorb water and soften, have poor protection against moisture and oxygen-sensitive drugs, and the capsule shell has delayed disintegration and drug dissol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42A23L33/00
Inventor 张慧君辛德慧薄力影周福玲王文霞郑喜群宋秘钊
Owner QIQIHAR UNIVERSITY
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