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Composition containing sesamin, gamma-oryzanol and rice germ oil

A technology of rice germ oil and oryzanol is applied in the directions of medical preparations containing active ingredients, drug combinations, active ingredients of heterocyclic compounds, etc. Excellent antioxidant effect

Active Publication Date: 2016-10-05
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to form an emulsion for the purpose of improving absorbability, fat-soluble substances need to be uniformly emulsified, and a complicated process is required, so there is a problem of high cost

Method used

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  • Composition containing sesamin, gamma-oryzanol and rice germ oil
  • Composition containing sesamin, gamma-oryzanol and rice germ oil
  • Composition containing sesamin, gamma-oryzanol and rice germ oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1. Study of absorbability by eversioned intestinal sac pattern

[0082]

[0083] Male SD rats (7 weeks old) were domesticated in the test environment and used for the experiment. After laparotomy and blood removal under anesthesia, the small intestine (mainly the jejunum) about 15 cm from the pylorus was immediately removed and divided into two. Bind one side with a thread, reverse the outer side and the inner side, and fill with the adjustment solution (inner solution: NaCl 140mM, CaCl 2 0.1mM, MgCl 2 0.5mM, D-mannose (D-mannose) 40mM, ascorbic acid (Ascorbic acid) (0.8mM, 10mM Tris, pH7.4), and then tied the other side to make a 5cm everted intestinal pouch. Add 0.5 ml of control solution or test solution to 4.5 ml of conditioning solution containing sodium taurocholate and albumin, and use ultrasonic waves for 3 minutes to form an emulsion, which is used as the external solution. The everted intestinal sacs were respectively immersed in the external solu...

Embodiment 2

[0087] Embodiment 2. Prescription example

preparation example 1

[0088] (Preparation Example 1) Granules

[0089]

[0090] After uniform mixing as above, 100 ml of 10% hydroxypropylcellulose-ethanol solution was added, stirred, squeezed, and dried according to the usual method to obtain granules.

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PUM

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Abstract

The present invention relates to a combination of a sesamin compound, gamma-orizanol and a rice germ oil.

Description

technical field [0001] The present invention relates to compositions such as in vivo absorption enhancers of sesamin and food and beverages or pharmaceutical compositions using them. Furthermore, the invention also relates to the use of the composition as an antioxidant. Background technique [0002] Sesamin is one type of lignan compounds contained in sesame. Among them, regarding sesamin and episesamin which is its stereoisomer, the effect of lowering cholesterol in blood, the effect of lowering neutral lipid in blood, the effect of improving liver function, the effect of scavenging active oxygen, the effect of Δ5 Various biological activities such as desaturase inhibitory activity, lipid peroxidation inhibitory activity, antihypertensive activity, hangover prevention activity, and breast cancer inhibitory activity (Patent Document 1). [0003] However, lignan compounds including sesamin are almost insoluble in water, and are soluble only to a certain extent in organic s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/36A23L33/10A61K31/575A61K47/28A61K47/44A61P1/16A61P3/00A61P3/06A61P9/12A61P35/00A61P39/06A61P43/00
CPCA61K31/36A61K31/575A61K36/88A61K2300/00A23L33/115A61P1/16A61P3/00A61P3/06A61P9/12A61P21/00A61P25/00A61P35/00A61P39/06A61P43/00
Inventor 一本松悠小野佳子富森菜美乃竹本大辅末安俊明
Owner SUNTORY HLDG LTD
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