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Gold nanoparticle array with simplex variation in steric hindrance structure and application of gold nanoparticle array

A technology of gold nanoparticles and steric hindrance, which is applied in nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, and can solve problems such as gold nanoparticle arrays with single change in steric hindrance structure

Active Publication Date: 2015-02-18
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the problems existing in the surface modification of existing nanomaterials, the purpose of the present invention is to provide a gold nanoparticle array with a single change in steric hindrance structure and its application

Method used

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  • Gold nanoparticle array with simplex variation in steric hindrance structure and application of gold nanoparticle array
  • Gold nanoparticle array with simplex variation in steric hindrance structure and application of gold nanoparticle array
  • Gold nanoparticle array with simplex variation in steric hindrance structure and application of gold nanoparticle array

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Effect test

Embodiment 1

[0055] Preparation of ligand molecules:

[0056] Lipoic acid (20mmol) and catalyst DCC (22mmol) were stirred in 60mL of dichloromethane for 1.5 hours. After lipoic acid was activated, DMAP (2mmol) and amine molecules (20mmol) were added, and the reaction was stirred at room temperature for 12 hours, and the reaction was completed. Afterwards, filter with suction, after the light yellow filtrate is vacuum rotary evaporated, add a small amount of ethyl acetate, ice bath until white powder appears, filter with suction, wash the filtrate twice with 0.05M sodium bicarbonate, and wash once with 1.9% hydrochloric acid , and finally washed once with high-purity water, put the organic phase in a conical flask, add anhydrous sodium sulfate to dry for half an hour, vacuum rotary evaporate the filtrate after suction filtration, take ethyl acetate / petroleum ether with a volume ratio of 2 / 1 for washing Remove the agent and purify through the column, and concentrate by rotary evaporation to ...

Embodiment 2

[0061] Topography Analysis of Gold Nanoparticle Arrays Using Transmission Electron Microscopy:

[0062] All gold nanoparticles were observed by transmission electron microscopy. The morphology of gold nanoparticles observed under JEOL1200EX transmission electron microscope, voltage 80KV, AMT2k CCD lens is as follows figure 2 As shown, the gold nanoparticles are approximately spherical, with an average particle size of 4.6±0.4 nm.

Embodiment 3

[0064] Steric hindrance analysis of gold nanoparticles:

[0065] According to the molecular weight of the ligand connected to the gold nanoparticle and the size of the ligand molecule, the size of the steric hindrance of the gold nanoparticle is represented by a number, and the size of the steric hindrance of the gold nanoarray is calculated by computer software, GNP-1 to GNP The values ​​of -6 steric hindrance index are shown in Table 2. Its changes from small to large are: 0.032, 0.069, 0.087, 0.095, 0.134, 0.146, where the smaller the value, the smaller the steric hindrance, and the larger the numerical value, the greater the steric hindrance.

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Abstract

The invention discloses a gold nanoparticle array with simplex variation in a steric hindrance structure. The gold nanoparticle array consists of six kinds of nanoparticles, expressed by GNP-1, GNP-2, GNP-3, GNP-4, GNP-5 and GNP-6, wherein 422-869 ligand molecules are connected with each gold nanoparticle; each gold nanoparticle is near-spherical with the average grain diameter of 4.2-5.0 nanometers. The array is obtained through connecting ligands with different steric hindrances and connecting the ligand molecules with the gold nanoparticles through gold-sulfur bond covalent interaction. The invention further discloses application of the gold nanoparticle array in study of interaction of nanoparticle and cells, and the design of application of targeted conveying drugs, biological developing, disease diagnosis, gene therapy and the like to the bio-medical field can be guided.

Description

technical field [0001] The invention relates to a gold nanoparticle array, in particular to a gold nanoparticle array with a single change in steric hindrance structure and its application; it belongs to the technical field of functional modification of the surface of nanomaterials. Background technique [0002] As an emerging material, nanomaterials are widely used in sporting goods, food, cosmetics, clothing, dyes, etc., in biomedical fields such as drug carriers, cancer treatment, antibacterial materials, tissue engineering, medical diagnosis, and biosensing. It also has broad application prospects. At the same time, the safety of nanomaterials has attracted more and more attention, especially the influence of the biological activity of nanomaterials on cells, organs and even the organism itself. Among them, the surface ligand properties of nanomaterials are an important factor affecting their biological activity. The properties of these surface ligands include hydrophi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B1/00B82Y5/00B82Y30/00
Inventor 闫兵李非非孙海南张秋翟淑梅江翠娟张斌
Owner SHANDONG UNIV
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