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Orally-taken chemotherapy tablet for treating stomach cancer

A technology for tablets and gastric cancer, which is applied in the field of oral chemotherapy tablets for the treatment of gastric cancer, can solve the problems of cardiotoxicity, easily cause dehydration, hinder popularization and use, etc., and achieves reduction of toxicity, good killing of tumor cells, and improvement of hardness and disintegration. performance effect

Inactive Publication Date: 2015-02-18
王喜功
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Xeloda (capecitabine tablets) is the main oral chemotherapy drug on the market, but its further popularization is hindered by its limitations such as cardiotoxicity and easy dehydration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An oral chemotherapy tablet for the treatment of gastric cancer, consisting of the following components: capecitabine 58.6mg, cisplatin liposome 17.9mg, oteracil potassium 20.4mg, hydrous lactose 4.6mg, magnesium stearate 2.8mg , Microcrystalline cellulose 3.3mg, pregelatinized starch 4.2mg, starch 38.2mg.

Embodiment 2

[0023] An oral chemotherapy tablet for the treatment of gastric cancer, consisting of the following components: 55 mg capecitabine, 19.5 mg cisplatin liposome, 16.2 mg oteracil potassium, 35.2 mg aqueous lactose, 2.5 mg magnesium stearate, Microcrystalline cellulose 4.2mg, pregelatinized starch 3.7mg, starch 13.7mg.

Embodiment 3

[0025] An oral chemotherapy tablet for treating gastric cancer, consisting of the following components: 79 mg capecitabine, 15.8 mg cisplatin liposome, 22.4 mg oteracil potassium, 3.4 mg aqueous lactose, 3.6 mg magnesium stearate, Microcrystalline cellulose 2.8mg, pregelatinized starch 4.6mg, starch 18.4mg.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to an orally-taken chemotherapy tablet for treating the stomach cancer. The orally-taken chemotherapy tablet is prepared from the following constituents: 55-79 mg of capecitabine, 15.8-19.5 mg of lipoplatin, 16.2-22.4 mg of potassium oxonate, 3.4-5.2 mg of lactose hydrous, 2.5-3.6 mg of magnesium stearate, 2.8-4.2 mg of microcrystalline cellulose, 3.7-4.6 mg of pre-gelatinized starch, and the balance of starch, wherein the total dosage is 150 mg; capecitabine, lipoplatin and potassium oxonate serve as medicinal constituents. The tablet disclosed by the invention is convenient to use, short in course of treatment, effective in treatment, and low in side effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an oral chemotherapy tablet for treating gastric cancer. Background technique [0002] Gastric cancer ranks first among various malignant tumors in my country. Most patients with early gastric cancer have no obvious symptoms, and a few people have nausea, vomiting or upper gastrointestinal symptoms similar to ulcer disease. Pain and weight loss are the most common clinical symptoms of advanced gastric cancer. Patients often have relatively clear upper gastrointestinal symptoms, such as upper abdominal discomfort and fullness after eating. As the condition progresses, upper abdominal pain increases, appetite decreases, and fatigue develops. Patients with advanced gastric cancer often experience symptoms such as anemia, weight loss, malnutrition and even cachexia. [0003] For the treatment of gastric cancer, surgery or chemotherapy is mainly used. However, the methods of sur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K9/20A61P35/00
CPCA61K31/7068A61K9/2059A61K31/53A61K33/24
Inventor 王喜功潘吉荣
Owner 王喜功
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