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Spray film forming preparation for burn and scald injury

A spray film forming and preparation technology, which is applied in the field of medicine, can solve the problems of cross contamination, inconvenient use, and affecting the treatment effect, and achieve the effect of recovery

Inactive Publication Date: 2015-02-18
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] After burns and scalds on the human skin, semi-solid drugs such as creams and gels are generally used to treat the injured skin. These drugs are usually applied to the surface of the wound by fingers or utensils, which is easy to cause drug coating. Inhomogeneity and cross-contamination affect the treatment effect
[0003] At present, sulfadiazine drugs are widely used in the treatment of burns and scalds, and the adopted dosage forms are common external preparations such as creams for treatment. Such common preparations are not suitable for wound treatment. Cloth is easy to cause cross-contamination and inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription

[0030] Silver Sulfadiazine 10g

[0031] Polyvinyl alcohol (17-88) 5g

[0032] Hydroxypropyl Cellulose (EF) 25g

[0033] Glycerin 10g

[0034] Talc powder 15g

[0035] Silica 3g

[0036] Sorbic acid 0.3g

[0037] Add deionized water to 500g

[0038] Preparation:

[0039] Heat and boil deionized water and place it in a stainless steel container, add the prescribed amount of polyvinyl alcohol into the boiling water, stir and dissolve, then add hydroxypropyl cellulose and sorbic acid into the stainless steel container to fully swell and dissolve for 24 hours at room temperature to produce A solution containing polyvinyl alcohol and hydroxypropyl cellulose; adding micronized silver sulfadiazine to the above polymer material solution, stirring and mixing evenly, adding glycerin, adding talcum powder and silicon dioxide to the mixture, and stirring and mixing for 10 minutes; Stir simultaneously with sodium hydroxide with a pH of a...

Embodiment 2

[0041] prescription

[0042] Zinc Sulfadiazine 25g

[0043] Polyvinyl alcohol (17-88) 5g

[0044]Hypromellose (50CP) 10g

[0045] Glycerin 15g

[0046] Talc powder 20g

[0047] Peptide Dioxide 2.0g

[0048] Sodium Benzoate 0.4g

[0049] Deionized water 500g

[0050] Preparation:

[0051] Heat and boil deionized water and place it in a stainless steel container, add the prescribed amount of polyvinyl alcohol into the boiling water, stir and dissolve, then add hypromellose and sodium benzoate into the stainless steel container and fully swell for 24 hours at room temperature to produce A solution containing polyvinyl alcohol and hypromellose; add micronized zinc sulfadiazine to the above polymer material solution, stir and mix evenly, then add glycerin, add talcum powder and dioxidized peptide to the mixture, and stir and mix for 10 minutes ; If necessary, adjust the pH to about 6-8 with sodium hydroxide or hydrochloric acid while stirring. A unif...

Embodiment 3

[0053] prescription

[0054] Sulfadiazine 10g

[0055] Polyvinyl alcohol (17-88) 15g

[0056] Hypromellose (MF) 10g

[0057] Glycerin 25g

[0058] Talc powder 15g

[0059] Silica 10g

[0060] Benzoic acid 0.2g

[0061] Deionized water 500g

[0062] Preparation:

[0063] Heat and boil deionized water and place it in a stainless steel container, add the prescribed amount of polyvinyl alcohol into the boiling water, stir and dissolve, then add hydroxypropyl cellulose and benzoic acid into the stainless steel container to fully swell and dissolve for 24 hours at room temperature to produce A solution containing polyvinyl alcohol and hydroxypropyl cellulose; add micronized sulfadiazine to the above polymer material solution, stir and mix well, then add glycerin, add talc powder and silicon dioxide to the mixture, stir and mix for 10 minutes to form a uniform After passing the inspection, each aerosol bottle is filled with about 10ml.

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Abstract

The invention discloses a spray film forming preparation for burn and scald injury. The preparation contains sulfadiazine, a biocompatible macromolecular film forming component with at least 2% by weight of polyvinyl alcohol and hydroxy propyl methyl cellulose (HPMC), a plasticizer, an anti-sticking agent and a bacteriostatic agent which are combined. According to the spray film forming preparation, sulfadiazine, the film forming component, the anti-sticking agent and the plasticizer are mixed to form suspension, the suspension is sprayed to the burned skin, and a film is formed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a convenient spray film-forming preparation prepared from sulfadiazine-containing medicines. The spray film-forming preparation has a good therapeutic effect on burns and scalds. Background technique [0002] After burns and scalds on human skin, semi-solid drugs such as creams and gels are generally used to treat the injured skin. These drugs are usually applied to the surface of the wound by fingers or utensils, which is easy to cause drug coating. Inhomogeneity and cross-contamination will affect the treatment effect. [0003] At present, sulfadiazine drugs are widely used in the treatment of burns and scalds, and the adopted dosage forms are common external preparations such as creams for treatment. Such common preparations are not suitable for wound treatment. Cloth is easy to cause cross-contamination, and it is inconvenient to use. The present invention aims at solving th...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/63A61K47/38A61P17/02A61P31/04
Inventor 张自强刘宇婧
Owner 南京泽恒医药技术开发有限公司
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