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A kind of highly stable astaxanthin ester self-microemulsion and preparation method thereof

A technology of astaxanthin ester and microemulsion, which is applied in the fields of pharmaceutical formulation, emulsion delivery, cosmetic preparation, etc., can solve the problems of poor water solubility and poor storage stability of astaxanthin ester, and achieve good stability and simple production process , the effect of inhibiting degradation

Active Publication Date: 2018-05-18
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a high stability astaxanthin ester self-microemulsion and its preparation method, thereby solving the two technical problems of poor water solubility and poor storage stability of astaxanthin ester, so that astaxanthin ester can be used in water phase food, The application in medicine and daily chemical products becomes possible, which broadens the scope of application and consumption of astaxanthin ester

Method used

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  • A kind of highly stable astaxanthin ester self-microemulsion and preparation method thereof
  • A kind of highly stable astaxanthin ester self-microemulsion and preparation method thereof
  • A kind of highly stable astaxanthin ester self-microemulsion and preparation method thereof

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Embodiment 1

[0035] Using the astaxanthin ester crude extract derived from Haematococcus pluvialis as raw material, wherein the astaxanthin ester content is 7% (purchased from Yunnan Aierfa Biological Engineering Co., Ltd.), weigh 1g of the astaxanthin ester crude extract and 0.1g of tocopheryl acetate, then dissolved in 3ml of ethyl acetate to make astaxanthin ester-tocopheryl acetate-ethyl acetate solution; take 1ml of the above astaxanthin ester-tocopheryl acetate-ethyl acetate Add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1) to the ester solution, stir evenly at 40°C, then add 10ml of pH7.0 phosphate buffer solution, and homogenize at high speed to obtain high-stable astaxanthin ester From the microemulsion, observe the appearance of the system and measure the particle size and stability, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 61nm (such as figure 2 Shown), illustrate that the present embodiment 1 p...

Embodiment 2

[0037] The astaxanthin ester crude extract derived from Haematococcus pluvialis was used as raw material, wherein the astaxanthin ester content was 7% (purchased from Yunnan Aierfa Bioengineering Co., Ltd.), and 1g of the astaxanthin ester crude extract was weighed, Then dissolve it with 3ml of ethyl acetate to form astaxanthin ester-ethyl acetate solution; take 1ml of the above astaxanthin ester-ethyl acetate solution, add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1), and Stir evenly at 40°C, then add 10ml of pH 7.0 phosphate buffer solution pre-dissolved with 0.1g of ascorbic acid, homogenize at high speed to obtain a highly stable astaxanthin ester self-microemulsion, observe the appearance of the system and measure the particle size and stability properties, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 65nm, indicating that the present embodiment 1 prepares a highly water-soluble self-microemul...

Embodiment 3

[0039]The astaxanthin ester crude extract derived from Haematococcus pluvialis was used as raw material, wherein the astaxanthin ester content was 7% (purchased from Yunnan Aierfa Bioengineering Co., Ltd.), and 1g of the astaxanthin ester crude extract was weighed, Then dissolve it with 3ml of ethyl acetate to form astaxanthin ester-ethyl acetate solution; take 1ml of the above astaxanthin ester-ethyl acetate solution, add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1), and Stir evenly at 40°C, then add 10ml of pH 7.0 phosphate buffer solution pre-dissolved with 0.1g of ethylenediaminetetraacetic acid, homogenize at high speed to obtain a highly stable astaxanthin ester self-microemulsion, observe the appearance of the system and measure Particle size and stability, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 63nm, illustrating that the present embodiment 1 prepares a highly water-soluble self-micro...

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Abstract

The invention provides a method for preparing a high-stability astaxanthin ester self-microemulsion, by mixing a certain proportion of astaxanthin ester, carrier oil, stabilizer, emulsifier, co-emulsifier and water phase under specific process conditions Mixing under low pressure, and then the solvent was removed by low-pressure distillation, and finally a self-microemulsion of astaxanthin ester with high stability was prepared. The astaxanthin ester self-microemulsion prepared by the present invention can be self-microemulsified in an aqueous medium to form a transparent microemulsion with a particle diameter within 100nm, which improves the solubility of astaxanthin ester in water and simultaneously makes astaxanthin ester The storage stability of astaxanthin has been significantly enhanced, which has solved the two problems of water insolubility and low stability of astaxanthin ester, and made it possible for astaxanthin ester to be applied in water phase food, medicine and daily chemical products.

Description

technical field [0001] The invention belongs to the technical field of preparation of active substance preparations, and in particular relates to a high-stable astaxanthin ester self-microemulsion and a preparation method thereof. Background technique [0002] Astaxanthin, also known as astaxanthin and lobster shell pigment, has a chemical name of 3,3'-dihydroxy-β,β-carotene-4,4'-dione, and its molecular formula is C 40 h 52 o 4 , with a relative molecular mass of 596.86, widely present in marine animals and plants, because astaxanthin has various biological functions such as anti-oxidation, anti-inflammation, coloration, light protection, and promotion of reproduction, it has become very popular in food and medicine at home and abroad in recent years. , cosmetics, aquaculture and other industries. Studies have found that in nature, more than 90% of astaxanthin exists in the form of esterification, and astaxanthin esters are more stable than free astaxanthin. And the pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/215A61K8/37A61K8/06A23L33/00A23L5/40A23L5/41
Inventor 薛长湖周庆新王玉明徐杰常耀光李学敏尹利昂
Owner OCEAN UNIV OF CHINA
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