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Synthesis method of rebaudioside M, intermediate product of rebaudioside M and synthesis method of intermediate product of rebaudioside M

A synthesis method and compound technology, applied in the synthesis method of rebaudioside M and its intermediate products and synthesis, natural products and non-toxic reagents, can solve the problems that have not yet been realized in industrial production, and achieve high conversion rate and product purity high effect

Inactive Publication Date: 2015-02-11
成都华高瑞甜科技有限公司
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Problems solved by technology

This method is still in the research stage and has not yet achieved industrial production

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  • Synthesis method of rebaudioside M, intermediate product of rebaudioside M and synthesis method of intermediate product of rebaudioside M
  • Synthesis method of rebaudioside M, intermediate product of rebaudioside M and synthesis method of intermediate product of rebaudioside M
  • Synthesis method of rebaudioside M, intermediate product of rebaudioside M and synthesis method of intermediate product of rebaudioside M

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Embodiment Construction

[0086] The above-mentioned content of the present invention will be further described in detail below through specific implementation in the form of examples, but it should not be understood that the scope of the above-mentioned subject of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0087] 1. Preparation of Compound B

[0088] route a

[0089]

[0090] 8.04g compound A was suspended in 25mL ethyl acetate, DMAP 0.25g was added, Et 3 N 5mL, slowly drop Ac 2 O15ml, react at 50-60°C for 4 hours, TLC monitors that the reaction is complete, stop heating, and cool to room temperature. The reaction mixture was diluted with 40 mL ethyl acetate, and the organic phase was sequentially washed with appropriate amount of water, saturated NaHCO 3 Wash with aqueous solution and then with water to bring the pH to neutral. to get compound B 1 1...

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Abstract

The invention belongs to the field of food chemical industry, relates to a synthesis method of rebaudioside M, an intermediate product of the rebaudioside M and a synthesis method of the intermediate product of the rebaudioside M, and particularly relates to a process method which uses ready-made natural products and non-toxic reagents and is applicable to industrial production. The provided synthesis method of the rebaudioside M is bran-new. The synthesis method provided by the invention comprises the following routes: (1) protecting hydroxyl groups of a compound A, so as to obtain a compound B; (2) enabling the compound B and a compound C to react in the presence of a phase transition reagent and an inorganic base, so as to obtain a compound D; (3) removing protecting groups of R1 and R2 from the compound D, thereby obtaining the rebaudioside M. The method has the advantages that the preparation method is simple and is easy in operation, the purity of a product is high, and the conversion ratio is high.

Description

technical field [0001] The invention belongs to the field of food chemical industry, and relates to a synthesis method of rebaudioside M and its intermediate product and synthesis method, in particular to a process method using ready-made natural products and non-toxic reagents, which is suitable for industrial production. Background technique [0002] Sweeteners are a class of food additives used in food and beverage production. At present, there are more than 20 kinds of sweeteners widely used in the world, and about 15 kinds have been approved for use in my country. According to the source, sweeteners can be divided into two categories: the first category is natural sweeteners, such as glucose, sucrose, etc., which have the disadvantages of high calories and limited consumption by special groups; the second category is Chemically synthesized sweeteners are completely synthesized by chemical methods. Saccharin is the earliest edible chemically synthesized sweeteners. In a...

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Application Information

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IPC IPC(8): C07H15/256C07H1/00C07H13/06C07H15/18
CPCY02P20/55C07H15/256C07H1/00C07H13/06C07H15/18
Inventor 余红伟李虹霖秦岭许庆
Owner 成都华高瑞甜科技有限公司
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