Isoflavone derivatives and their preparation methods and applications

A technology of derivatives and isoflavones, which is applied in the field of isoflavone derivatives and its preparation, can solve the problems of unseen bell bean metabolic syndrome and diabetes research reports, etc.

Inactive Publication Date: 2017-11-03
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no research report on the treatment of metabolic syndrome and diabetes with bell bean extract

Method used

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  • Isoflavone derivatives and their preparation methods and applications
  • Isoflavone derivatives and their preparation methods and applications
  • Isoflavone derivatives and their preparation methods and applications

Examples

Experimental program
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Effect test

Embodiment

[0026] Take 20 kg of the whole herb of bell bean, add 100 L of ethanol aqueous solution with a volume fraction of 95% after crushing, and carry out reflux extraction, each time of reflux extraction for 2 hours, and extract 4 times in total; combine the extracts, filter, and concentrate under reduced pressure; The paste was suspended in water, and the suspension was extracted several times with petroleum ether until the petroleum ether layer was nearly colorless; then the collected water layer was extracted with ethyl acetate until the ethyl acetate layer was nearly colorless; the collected ethyl acetate was concentrated under reduced pressure. ester layer to obtain the ethyl acetate part; the obtained ethyl acetate part was subjected to silica gel column chromatography, and then eluted with petroleum ether and petroleum ether-ethyl acetate with a volume ratio of 1:0.2, and the collection volume ratio was 1: 0.2 of petroleum ether-ethyl acetate eluate; concentrated under reduced...

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Abstract

The invention discloses isoflavone derivatives, and a preparation method and an application thereof. The derivatives are compounds with the structural formula represented by general formula I, II or III. In the above formulas, R1, R2, R3 are respectively selected from hydrogen, hydroxyl groups or C1-C10 alkoxy groups; R4 is a C1-C20 saturated alkyl group or a C1-C20 alkyl group with at least one of the following substituents: a hydroxyl group, an amino group, an alkylene group and a C1-C10 alkoxy group, and the alkoxy group can be linear or branched; and R5 is oxygen, sulfur or an imino group. The derivatives are prepared through solvent extraction, column chromatography separation and purification of a Crotalaria albida medicinal material or newly picked herb of Crotalaria albida as raw material. Experiments prove that the derivatives have a competitive antagonist effect on PPAR-gamma receptors and have a differentiation inhibition effect on 3T3-L1 cells, so the derivatives could be used to prepare medicines for treating metabolic syndromes as an active component.

Description

technical field [0001] The invention relates to isoflavone derivatives and a preparation method and application thereof, belonging to the technical field of medicine. Background technique [0002] Metabolic syndrome is a common disease characterized by abnormal glucose and lipid metabolism, accompanied by elevated low-density lipoprotein and low high-density lipoprotein cholesterol. The common symptoms are obesity, diabetes, hyperlipidemia and atherosclerosis Among them, diabetic patients often have hyperlipidemia, cardiovascular disease, diabetic nephropathy, diabetic neuropathy and other diseases. [0003] According to the World Health Organization, more than 220 million people worldwide suffer from diabetes. Among them, China has become the country with the largest number of diabetics in the world, with a total of 92 million diabetics. According to the "New England Journal of Medicine" published on March 25, 2010 According to the data of the research report, there are cur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04C07D407/12A61K31/352A61P3/10A61P5/50A61P3/06A61P3/04A61P9/10A61P9/12
CPCC07D407/04C07D407/12
Inventor 侴桂新孙秦虎张玉
Owner SHANGHAI UNIV OF T C M
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