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Morinda officinalis pure powder ultrafine decoction pieces and preparation method thereof

A kind of Morinda officinalis meat, ultra-micro technology, applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of reduced content of active ingredients, low bioavailability, low dissolution rate, etc., to achieve odor and Improved taste, high bioavailability, and good stability

Active Publication Date: 2017-01-04
磐安县道地磐药中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to overcome the low drug dissolution rate of traditional Chinese medicine oral preparations of Morinda officinalis in the prior art, the content of active ingredients is reduced, the bioavailability is low, and the process conditions of conventional ultrafine grinding technology are not suitable for Morinda officinalis tablets preparation, the prepared oral preparations have defects such as easy decomposition of active ingredients, many impurities, poor content uniformity, poor stability, etc., and a preparation process and preparation method of ultrafine decoction pieces of Morinda officinalis pure powder are provided

Method used

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  • Morinda officinalis pure powder ultrafine decoction pieces and preparation method thereof
  • Morinda officinalis pure powder ultrafine decoction pieces and preparation method thereof
  • Morinda officinalis pure powder ultrafine decoction pieces and preparation method thereof

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Effect test

Embodiment 1-3

[0032] The preparation method of Morinda officinalis extract in embodiment 1-3 comprises the following steps:

[0033] The active ingredient of Morinda officinalis is extracted according to the following extraction method: dry the Morinda officinalis, then crush it to 40-80 mesh, place it in a supercritical extraction kettle, add entraining agent, and convert carbon dioxide into a supercritical fluid through a high-pressure pump , the first secondary extraction under the first pressure for 2-4 hours, extract the extracted solution under reduced pressure and analyze the first crude extract, disperse the first crude extract in hot water, and concentrate under reduced pressure to 1 / 8 of the original volume , then left to stand for crystallization, repeated 2-3 times, and then the first extract was obtained; the kettle was extracted under the second pressure for 3-4 hours, and the extract was decompressed and analyzed to obtain the second crude extract, which was then extracted Di...

Embodiment 1

[0036] Preparation Process:

[0037] The dried active ingredient of Morinda officinalis meat is pulverized to a particle size of less than 300 microns, sterilized by radiation, and then ultrafinely pulverized to 40 microns in a jet mill, and 90% of the particles with a particle size of less than 65 microns accumulate to obtain Morinda officinalis Meat pure powder superfine drink slices.

[0038]Among them, the temperature of vacuum drying is 100°C, and the pressure is 0.1mpa; the conditions of ultrafine pulverization are: pulverization temperature 20°C, pressure when entering the ultrafine pulverizer is 1.5Mpa, pulverization pressure 3Mpa, air velocity 220m / s, pulverization The time is 1.5h;

[0039] The prepared ultrafine decoction pieces and auxiliary materials meeting the pharmaceutical requirements are prepared into tablets, capsules, or other oral constant-release dosage forms.

Embodiment 2

[0041] Preparation Process:

[0042] Grinding the dried active ingredients of Morinda officinalis meat to a particle size of less than 300 microns, microwave sterilization, and then superfinely pulverizing to 50 microns in a jet mill, and accumulating 95% of the particles with a particle size of less than 65 microns to obtain Morinda officinalis Meat pure powder superfine drink slices.

[0043] Among them, the temperature of vacuum drying is 90°C, and the pressure is 0.2mpa; the conditions of ultrafine pulverization are: pulverization temperature 20°C, pressure when entering the ultrafine pulverizer is 1.5Mpa, pulverization pressure 5Mpa, air velocity 260m / s, pulverization The time is 1.5h;

[0044] The prepared ultrafine decoction pieces and auxiliary materials meeting the pharmaceutical requirements are prepared into tablets, capsules, or other oral constant-release dosage forms.

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Abstract

The invention discloses a preparation method of ultrafine decoction pieces of Morinda officinalis pure powder and the prepared product. Preparation method: after washing the fresh Morinda officinalis meat, dry it by freeze-drying technology, then crush the active ingredients of the dried Morinda officinalis meat to a particle size of less than 300 microns, and then ultrafinely pulverize it in an airflow mill to obtain the Morinda officinalis officinale The ultrafine decoction pieces of halberd meat pure powder, the conditions of ultrafine pulverization are: pulverization temperature 15-22°C, pressure when entering the ultrafine pulverizer is 1-2Mpa, pulverization pressure 2-6Mpa, air velocity 200-285m / s, the crushing time is 1‑3h. The oral preparation prepared by the preparation process has good drug effect, good dissolution property, good stability, high bioavailability, and improved odor and mouthfeel.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to superfine decoction pieces of Morinda officinalis pure powder and a preparation method thereof. Background technique [0002] Morinda officinalis How (scientific name: Morinda officinalis How), is a dicotyledonous plant Rubiaceae (Rubiaceae), 3-13cm long, 1.5-5cm wide, short and acuminate at the front end, blunt or round at the base. The dry root of Morinda officinalis, the root is flat and cylindrical, slightly curved. Mainly produced in Guangdong, Guangxi and other places. Medicinal plants, mainly used to treat impotence and nocturnal emission, uterine cold and infertility, irregular menstruation, cold and pain in the lower abdomen, rheumatic arthralgia, muscle and bone flaccidity. [0003] In order to meet the needs of modern health, many time-honored Chinese medicine brands have been formed in the field of traditional Chinese medicine preparations in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/746
Inventor 傅苗青马国军
Owner 磐安县道地磐药中药研究所
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