Preparation method of frankincense particles

A technology of frankincense and granules, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of inability to concentrate, reduce the dosage, and inconvenience of taking, so as to make it easy to take. and carrying, the finished product has good solubility, and the effect of reducing the amount of auxiliary materials

Active Publication Date: 2015-02-04
广东省中医药工程技术研究院
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, frankincense formula granules have been sold on the market, but the existing frankincense formula granules are extracted by water decoction, spray-dried, and dry-pressed. Since frankincense mainly contains 60% to 70% of resin and 27% to 35% of gum %, 3% to 8% volatile oil, the above ingredients are easily soluble in organic solvents, and the solubility in water is low. In the prior art, there are often the following problems when decocting and extracting frankincense formula granules:
[0005] 1. Since frankincense decoction pieces contain a large amount of resin and gum substances, their water solubility is poor. When decoction is used for extraction, the decoction pieces tend to form agglomerates and adhere to the bottom of the extraction tank, resulting in incomplete extraction, which affects product quality and quality. clinical effect
[0006] 2. Due to the poor water solubility of resins and gums, the decoction extract will have a large amount of precipitation as the temperature of the solution decreases and the concentration of the solution increases. The precipitates are easy to adhere to the pipe wall, and even block the pipe, resulting in concentration Impossible, at the same time, it will increase the difficulty of cleaning the concentration equipment
[0007] 3. The frankincense extract is directly spray-dried, and the spray-dried powder is easy to stick to the wall, resulting in a large loss of spray-dried powder and low yield of spray-dried powder
[0008] 4. Due to the poor water solubility of resins and gums, ordinary granules prepared from frankincense extracts have poor water solubility and are inconvenient to take. If they are prepared into suspension or effervescent special granules, the increase will be significant. The amount of excipients cannot achieve the effect of reducing the dosage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of frankincense particles
  • Preparation method of frankincense particles
  • Preparation method of frankincense particles

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The embodiment of the present invention provides a method for preparing frankincense particles, which includes the following steps:

[0022] S01: Add frankincense to boiling water 10-20 times its mass, stir and keep boiling for 0.5-2 hours, then add 5-40% water-soluble starch auxiliary materials of the frankincense mass, stir until the auxiliary materials melt, The medicinal liquid is separated from the medicinal residue, and the medicinal liquid is the first decoction extract;

[0023] S02: Add water of 8-12 times the mass of the frankincense to the medicinal residue, heat it to boiling for 0.25 to 1 hour and then combine the liquid with the first decoction extract to obtain the frankincense extract;

[0024] S03: Concentrate the frankincense extract at 50-80°C to 2.5-5 times the mass of the frankincense to obtain a frankincense cream;

[0025] S04: heating the frankincense ointment to above 95°C and spray drying to obtain frankincense spray powder;

[0026] S05: Dry granulatio...

Embodiment 1

[0034] The frankincense decoction pieces are 100kg, add water and decoct for 2 times. For the first time, add 15 times the amount of water to the extraction tank. After heating and boiling, keep a slight boil, turn on the extraction tank stirrer, stirring speed 60rpm, and put the frankincense decoction pieces in batches , After feeding, keep stirring, heating and decocting for 1.5 hours, add 25% maltodextrin of the amount of decoction pieces, and stir for 10 minutes. After all the auxiliary materials are melted, extract the liquid medicine and filter the extract to obtain the first decoction Extraction solution; adding 8 times the amount of water for the second time, heating and decoction for 0.5 hours, the extract is filtered, and combined with the first decoction extract to obtain Boswellia extract; the Boswellia extract is pumped into the concentrator, The concentration temperature is controlled between 50 and 80°C. When the extract is concentrated to 4.3 times the feeding am...

Embodiment 2

[0038] Receive 100kg of vinegar frankincense decoction pieces, add water to decoct 2 times, add 16 times the amount of water to the extraction tank for the first time, heat and boil, keep it slightly boiling, turn on the extraction tank stirrer, stirring speed 50rpm, put in portions Vinegar frankincense decoction pieces, after feeding, keep stirring, heating and decocting for 1.5 hours, add 30% of the soluble starch of the decoction piece dosage, stirring for 10 minutes, after all the auxiliary materials are melted, extract the medicinal solution, and the extract is filtered. One decoction extract; the second time add 10 times the amount of water, heat and decoct for 0.5 hours, the extract is filtered, and combined with the first decoction extract to obtain the frankincense extract, the frankincense extract is pumped to concentrate The concentration temperature is controlled between 50 and 80°C. When the extract is concentrated to 4.5 times the feed amount, it is filtered throug...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a preparation method for frankincense particles. The preparation method comprises the following steps of adding frankincense in boiling water with a mass of 1-20 times that of the frankincense; stirring and decocting for 0.5-2 hours while keeping the boiling state; then adding a water-soluble starch type auxiliary material with a mass of 5-40% that of the frankincense; stirring to dissolve the auxiliary material; separating a medicinal solution from decoction dregs, the medicinal solution being a first decoction extracting liquid; adding water with a mass of 8-12 times that of the frankincense, heating to a boiling state, decocting for 0.25-1 hour, merging the liquid with the first decoction extracting liquid to obtain a frankincense extracting liquid; concentrating the frankincense extracting liquid at a temperature of 50-80 DEG C to a mass of 2.5-5 times that of the frankincense to obtain frankincense clear paste; heating the frankincense clear paste to a temperature higher than 95 DEG C and spray drying to obtain frankincense spray-dried powder; granulating the frankincense spray-dried powder by a dry method to obtain frankincense particles. The preparation technology is simple; conditions are mild; parameters can be controlled easily; extraction efficiency is high; and dissolubility of a finished product is good.

Description

Technical field [0001] The invention belongs to the technical field of Chinese medicine extraction and preparation, and specifically relates to a preparation method of frankincense granules. Background technique [0002] Frankincense is the resin exuded from the bark of Boswelliacarterii Birdw. of the olive family Boswelliacarterii Birdw. and the same genus Boswelliabhaw-dajiana Birdw. Frankincense Xin San Wen Tong, has the effect of activating blood circulation, relieving pain, reducing swelling and promoting muscle growth. It mainly treats chest pain, heartache, epigastric pain, dysmenorrhea, amenorrhea, postpartum stasis, abdominal pain, rheumatism arthralgia, tendons and pulse spasm, bruise , Carbuncle, sore, etc., clinically widely used in the treatment of rheumatism, rheumatoid arthritis and osteoarthritis. Frankincense mainly contains oleoresin, gum and volatile oil. Modern pharmacological research shows that the boswellic acid compounds contained in it have anti-inflamm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/324A61K9/16A61K47/36A61J3/00
CPCA61J3/00A61K9/1652A61K36/324A61K2236/331A61K2236/39
Inventor 涂瑶生孙冬梅王洛临张建军陈玉兴施之琪
Owner 广东省中医药工程技术研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap