Design of a Statically Sealed Multi-channel Nozzle for Chromatographic Columns

Abstract

A static seal multichannel nozzle design used for a chromatographic column is disclosed. The static seal multichannel nozzle comprises a silica gel feeding tube capable of moving up and down, a mobile flange, a mobile flange base, a fixture block, a belleville spring, a nozzle base, a seal ring, screen center nozzles, and the like. One end of the silica gel feeding tube is provided with seal grooves. The mobile flange can move along the axial direction of the silica gel feeding tube. The fixture block can drive the silica gel feeding tube to move along with the mobile flange. The belleville spring is disposed in a folded manner. The silica gel feeding tube passes through the center of the belleville spring. In particular, the pressure of gas provides power for movement of the silica gel feeding tube, thus facilitating automation. The seal grooves in one end of the silica gel feeding tube are matched with small holes in screen center arrays. Silica gel loading, chromatography and silica gel unloading can be performed simply. According to the static seal multichannel nozzle design, the seal form of spraying nozzles is changed from a motive seal form to a static seal form, so that the movement of the silica gel feeding tube is easier and more automatic, and seal effects are good.

Description

technical field [0001] The invention relates to a statically sealed multi-channel nozzle design for a chromatographic column, in particular to a glue inlet pipeline that can be lowered and lifted under the pressure of an air source, and the glue inlet can be sealed separately in the lowered and lifted states and connected. [0002] Background of the invention [0003] Chromatography column is the main body of gel chromatography technology. It is generally required to complete the entire chromatography operation of the solution in a clean and sterile workshop. Therefore, it is very necessary to avoid human intervention as much as possible and improve the automation capability of the chromatography column. [0004] The lifting of the nozzle can facilitate automatic glue loading, glue unloading, cleaning and other processes. In the prior art, even if it is a fully automatic chromatography column, the lifting of the spray head is still a manual operation, relying on the rotating...

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Problems solved by technology

Moreover, the lifting structure of this nozzle depends on the thread form. In actual operation, the nozzle needs to be lifted and lowered repeatedly. Once the thread has burrs or falls into the dust brought by the operator, the nozzle will be laborious to lift or even stuck, resulting in the entire nozzle. The failure of the nozzle, while the nozzle is repeatedly raised and lowered, the annular sealing ring of the nozzle is severely worn, the resistance is large, and the life is very short. In severe cases, debris may even fall out and pollute the rubber.

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