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Traditional Chinese medicine composition for resisting superbacteria NDM-1 drug resistance gene bacteria

A composition and drug technology, applied in the direction of antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of ineffective curative effect, difficult to show curative effect, not found, etc.

Pending Publication Date: 2015-01-21
郭进军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, once tested by the gold standard of in vivo antibacterial experiments of western medicine antibiotics, these Chinese patent medicines have shown no effect or weak curative effect. Strong drugs are less likely to show efficacy in this model
Therefore, after reviewing the literature, no antibacterial experiments in animals were found in which the above-mentioned marketed Chinese patent medicines and antibiotics were used as controls.

Method used

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  • Traditional Chinese medicine composition for resisting superbacteria NDM-1 drug resistance gene bacteria
  • Traditional Chinese medicine composition for resisting superbacteria NDM-1 drug resistance gene bacteria
  • Traditional Chinese medicine composition for resisting superbacteria NDM-1 drug resistance gene bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0154] Take 30 grams of forsythia, 30 grams of salvia miltiorrhiza, 30 grams of astragalus, and 30 grams of dandelion, decoct 3 times with water for 20 minutes each time, filter, and combine the filtrates. Concentrate under reduced pressure until every 1 ml is equivalent to 1 gram of raw medicinal material to obtain a decoction, or after cobalt 60 irradiation sterilization, bottle it to obtain an oral liquid.

[0155] Alternatively, the obtained extract concentrate is dried under reduced pressure until it becomes a dry paste, then an appropriate amount of starch is added, pulverized, mixed evenly, passed through an 80-mesh sieve, wet-granulated with 95% ethanol, dried below 80°C, sized, and made into granules or add an appropriate amount of magnesium stearate, mix well, compress into tablets, and coat to obtain tablets.

[0156] Alternatively, the obtained extract concentrate is dried under reduced pressure until it becomes a dry paste, then an appropriate amount of starch is ...

Embodiment 2

[0158] Take 40 grams of forsythia, 20 grams of salvia miltiorrhiza, and 30 grams of astragalus membranaceus, decoct 3 times with water, 20 minutes each time, filter, combine the filtrate, concentrate the filtrate to 1 / 5 volume for later use; concentrate under reduced pressure to the amount of raw medicinal materials per 1 ml 1 gram, add 15 grams of xylitol, stir well to get a decoction, or after cobalt 60 irradiation sterilization, bottle it to get an oral liquid.

[0159] Or make granules, tablets or capsules by the method described in Example 1.

Embodiment 3

[0161] Take 50 grams of forsythia, 30 grams of dandelion, 20 grams of salvia miltiorrhiza, and 25 grams of astragalus membranaceus, and boil them twice with water for 60 minutes each time. ) clear paste, when cooled to 40°C, slowly add ethanol under stirring to make the alcohol content reach 75%, fully stir, let stand for 12 hours, filter the supernatant, add an appropriate amount of 75% ethanol to the residue, stir well, Let it stand for 12 hours, filter, combine the ethanol solution, recover the ethanol until it has no alcohol smell, add 15 grams of xylitol, and then add purified water, each 1 ml is equivalent to 1 gram of raw medicinal material, stir well, and the decoction is obtained , or after cobalt-60 radiation sterilization, bottled to obtain the oral liquid.

[0162] Or concentrate under reduced pressure to form a thick paste, dry at low temperature, pulverize, add an appropriate amount of starch, mix well, (or granulate with ethanol, and dry.) Make granules, tablets...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition resistant to NDM-1 medicine resistant gene bacteria (superbacteria). The traditional Chinese medicine composition takes the medicines which benefit qi and activate blood circulation and clear away heat and toxic materials for compatibility and has exact treatment effects on various inflammations caused by standard bacteria strains and medicine resistant strains (such as KPC positive or superbacteria NDM-1 positive) such as respiratory tract infection, pelvic cavity infection, urinary infection and acute peritonitis. The medicine composition is a combined preparation of one or more of radix astragali, ginseng, American ginseng, dangshen, heterophylly falsestarwort root, largehead atractylodes rhizome, liquorice and Chinese yam, one or more of salvia miltiorrhiza, red peony root, leeches, Sichuan lovage rhizome, safflower, peach kernels, pseudo-ginseng, rosewood, rhizoma corydalis, ground beetle, motherwort herb, Chinese angelica and giant knotweed rhizome and one or more of honeysuckle, weeping forsythia capsule, isatis root, dyers woad leaf, dandelion, baical skullcap root, heartleaf houttuynia herb, dahurian patrinia herb, common andrographis herb, Tokyo violet herb, herba corydalis bungeanae, gueldenstaedtia multiflora bunge, globeflower and wild chrysanthemum in clinically reasonable doses.

Description

[0001] The patent application of the present invention is a divisional application, the original application number is 201310046748.0, the application date is February 5, 2013, and the invention name is: a traditional Chinese medicine composition against superbug NDM-1 drug-resistant gene bacteria. technical field [0002] The invention relates to a traditional Chinese medicine composition containing an anti-standard bacterial strain (antibiotic-sensitive bacterial strain), KPC-positive and NDM-1 drug-resistant gene bacteria (commonly known as super bacteria) and a preparation method thereof. It belongs to the field of pharmaceutical preparations. Background technique [0003] Since the invention of antibiotics, it has brought a turning point to people's lives, and human infectious diseases have been effectively controlled. However, due to the abuse of antibiotics by humans, more and more drug-resistant strains have emerged. For example, Staphylococcus aureus is a common ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K36/71A61K36/634A61P31/04A61P11/00A61P11/04
CPCA61K9/0095A61K9/1652A61K9/2013A61K35/62A61K36/185A61K36/19A61K36/195A61K36/232A61K36/236A61K36/258A61K36/284A61K36/286A61K36/287A61K36/288A61K36/315A61K36/344A61K36/355A61K36/36A61K36/48A61K36/481A61K36/484A61K36/533A61K36/537A61K36/539A61K36/634A61K36/65A61K36/66A61K36/704A61K36/71A61K36/736A61K36/78A61K36/855A61K36/86A61K36/8945A61K2300/00
Inventor 郭进军
Owner 郭进军
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