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Suspension containing albendazole, and preparation method thereof

A technology of albendazole and suspending agent, which is applied in the field of veterinary anticoccidiostats and its preparation, and can solve problems such as depletion of source glycogen, inability of worms to survive and reproduce, etc.

Inactive Publication Date: 2015-01-14
QINGDAO KDN BIOTECH
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Problems solved by technology

Albendazole selectively and irreversibly inhibits the polymerization of the cytoplasmic microtubule system of intestinal wall cells of parasites to intestinal nematodes, blocks their uptake and absorption of various nutrients and glucose, and leads to the depletion of endogenous glycogen in the worms. And inhibit the fumarate reductase system, prevent the production of adenosine triphosphate, so that the insects cannot survive and reproduce

Method used

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  • Suspension containing albendazole, and preparation method thereof

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example

[0021] Example: 5% albendazole aqueous suspension

[0022] 【Prescription】Albendazole 5%(W / V)

[0023] Gum tragacanth 0.8%(W / V)

[0024] Propylene Glycol 10%(W / V)

[0025] Poloxamer 0.3%(W / V)

[0026] Sodium Benzoate 0.2%(W / V)

[0027] Pure water added to 100% (V / V)

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Abstract

The invention belongs to the technical fields of antiparasitic drugs for animals, and preparation methods thereof, and concretely relates to a suspension containing albendazole, and a preparation method thereof. The above preparation comprises an albendazole bulk drug, a suspending aid, a wetting agent, an antiseptic and a flocculating agent. The suspension containing albendazole is prepared through a dispersion process, and is an off-white sticky water suspension. The suspension containing albendazole developed in the invention has the advantages of good stability, good palatability, long elimination half life, and high bioavailability, and can be used by animals as an oral preparation.

Description

technical field [0001] The invention belongs to the technical field of veterinary anticoccidial drugs and preparation methods, and particularly relates to a preparation method of a suspending agent of albendazole. [0002] technical background [0003] Albendazole (Albendazole), also known as prothiodazole, prothioimidazole, anti-helminth, chlorpyrifos, intestinal parasite clear, is a broad-spectrum anthelmintic with high efficiency and low toxicity. Clinically, it can be used to drive roundworms, pinworms, tapeworms, whipworms, hookworms, strongyloides, etc. After being metabolized into sulfoxide or sulfone in the body, it inhibits the parasite's absorption of glucose, resulting in depletion of glycogen in the parasite, or inhibits the fumarate reductase system, hindering the production of ATP, making the parasite unable to survive and reproduce. [0004] Albendazole is a benzimidazole derivative, which is rapidly metabolized into sulfoxide, sulfone alcohol and 2-amine su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4184A61K47/38A61K47/44A61K47/36A61K47/34A61K47/32A61P33/10A61P33/00
Inventor 郝智慧毕立学孙亚磊
Owner QINGDAO KDN BIOTECH
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