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Compound inhalation preparation containing carbapenem antibiotic and glucocorticoid

A technology of carbapenems and glucocorticoids, which is applied in the field of inhalation preparations, and can solve the problems of not finding the use of antibacterial drugs

Inactive Publication Date: 2014-12-17
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no antibacterial drugs, especially carbapenem antibiotics, have been used in the treatment of asthma and chronic obstructive pneumonia caused by non-microbial infections

Method used

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  • Compound inhalation preparation containing carbapenem antibiotic and glucocorticoid
  • Compound inhalation preparation containing carbapenem antibiotic and glucocorticoid
  • Compound inhalation preparation containing carbapenem antibiotic and glucocorticoid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] According to the following table, the active ingredient is micronized with a flow energy mill. The particle size of D90 is shown in the table below. 8g of anhydrous lactose is micronized with a flow energy mill to an average particle size of 36μm. In 1000 capsules size 3, the active ingredients in each capsule are listed in the table below.

[0046]

Embodiment 2

[0048] According to the table below, the active ingredient is micronized with a flow energy mill. The particle size of D90 is shown in the table below. 8g of anhydrous lactose is micronized with a flow energy mill to an average particle size of 40μm. In 1000 capsules size 3, the active ingredients in each capsule are listed in the table below.

[0049]

Embodiment 3

[0051] According to the table below, active ingredient 1 is micronized with a flow energy mill. The specific D90 particle size value is shown in the table below. Anhydrous lactose 5g is micronized with a flow energy mill. The specific value of the average particle size is shown in the table below. After mixing, pass through a 200-mesh sieve After mixing for 3 times, it is divided into 1000 No. 3 capsules, and the active ingredients in each capsule are shown in the table below.

[0052]

[0053] The preparation of aerosol, the active ingredient used is the weight of 1000 dosage units, HFA-134a is 1,1,1,2-tetrafluoroethane, HFA-227 is 1,1,1,2,3,3, 3-Heptafluoropropane.

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Abstract

The invention relates to a compound inhalation preparation containing carbapenem antibiotic and glucocorticoid and applications thereof. The carbapenem antibiotic is made into an inhalation dosage form, so that the preparation can treat pulmonary bacterial infection with less dosage form and the happening rate of adverse reactions in the gastrointestinal tracts is prominently reduced.

Description

Technical field: [0001] The invention relates to a compound inhalation preparation containing carbapenem antibiotics and glucocorticoid and its use. Background technique: [0002] Asthma and chronic obstructive pneumonia are airflow limitation diseases caused by respiratory inflammation. In recent years, with the influence of smoking, air pollution and allergens, the incidence rate has increased year by year. It has become an important public health problem affecting human health. At present, the treatment of asthma and chronic obstructive pneumonia is mainly based on inhalants, and compound drugs are mainly based on glucocorticoids and adrenergic β2-receptor agonists. At present, no antibacterial drugs, especially penicillin antibiotics, have been used in the treatment of asthma and chronic obstructive pneumonia caused by non-microbial infections. [0003] Glucocorticoids have anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects, and are widely ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/56A61K31/573A61K9/72A61K9/12A61P11/00A61P11/06A61P31/04A61K31/407A61K31/4196
Inventor 孙亮赵琳
Owner TIANJIN JINYAO GRP
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