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Application of Adrenergic Receptor Antagonist in the Preparation of Drugs for Alleviating Increased Sodium Current Caused by Brain Injury

A technology of receptor antagonist and epinephrine, which is applied in the preparation of drugs for alleviating the increase of sodium current caused by brain injury, field of adrenoceptor antagonist

Inactive Publication Date: 2017-04-12
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on how to control the electrophysiological changes of cell membranes to alleviate brain injury.

Method used

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  • Application of Adrenergic Receptor Antagonist in the Preparation of Drugs for Alleviating Increased Sodium Current Caused by Brain Injury
  • Application of Adrenergic Receptor Antagonist in the Preparation of Drugs for Alleviating Increased Sodium Current Caused by Brain Injury
  • Application of Adrenergic Receptor Antagonist in the Preparation of Drugs for Alleviating Increased Sodium Current Caused by Brain Injury

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Embodiment 1

[0022] Preparation of the perinatal hypoxic-ischemic model: take out the mouse 7 days after birth, put it in the supine position after ether anesthesia, fix the limbs and head, sterilize with 75% alcohol, make a median neck incision under a stereomicroscope, and separate the 1. Ligate and completely cut off the left common carotid artery, suture the skin and wait for the animal to recover. The resuscitated mice were placed in a hypoxic chamber with a capacity of 1L, which was placed in a constant temperature water bath, and the ambient temperature was maintained at 37°C, and then the oxygen-nitrogen mixture was continuously injected at 1L / min (the volume fraction of oxygen 8%, the volume fraction of nitrogen is 92%) for 2 hours, and the perinatal hypoxia-ischemia model was made. Spontaneous left-handed or tail-pinched left-handed subjects were included in subsequent experiments.

[0023] The perinatal hypoxic-ischemic model and normal mice were divided into 4 groups, namely b...

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Abstract

The invention discloses application of an adrenergic receptor antagonist in preparation of a drug for relieving sodium current increasing caused by brain injury. After a hypoxic-ischemic brain injury mouse is injected with the adrenergic receptor antagonist, the change of a sodium channel and increasing of a current amplitude can be significantly relieved, so that the adrenergic receptor antagonist can be applied to the preparation of the drug for relieving the sodium current increasing caused by the brain injury and has a potential application prospect in the treatment field of the brain injury.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of an adrenergic receptor antagonist in the preparation of medicines for alleviating the increase of sodium current caused by brain damage. Background technique [0002] Perinatal hypoxia-ischemia is an important cause of neonatal cerebral palsy. Oligodendrocyte precursor cells have higher sensitivity and vulnerability than neurons in hypoxic-ischemia, which is caused by hypoxic-ischemia Important target cells in cerebral palsy. The electrophysiological changes of oligodendrocyte precursor cells are more sensitive than the changes of morphology and receptor expression in hypoxia-ischemia, so controlling the electrophysiological changes of cell membranes to treat brain injury has higher sensitivity. However, there is no report on how to alleviate brain injury by controlling the electrophysiological changes of cell membranes. Contents of the invent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/517A61P25/00A61P9/10
Inventor 陈鹏慧阮怀珍
Owner ARMY MEDICAL UNIV
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