Serum surface enhanced Raman spectrum based parotid tumor diagnosis technology

Abstract

The invention relates to a serum surface enhanced Raman spectrum based parotid tumor diagnosis technology, which is a novel technology directed at parotid tumor diagnosis by head and neck tumor surgery and oral and maxillofacial surgery. The technology mainly solves the problem that a conventional biopsy technique cannot be employed for definite diagnosis of parotid tumor patients before operation, replaces the parotid tumor local puncture biopsy technology, avoids complications caused thereby, simultaneously alleviates the work intensity of pathologists, and provides the basis for surgeons to adopt different operative treatment modes according to the benign / malignant nature of tumors. According to the technology, nanoscale gold sol particles are added into parotid tumor patient serum to enhance the intensity of a Raman spectrum so as to obtain a characteristic surface enhanced Raman spectrum of the tumor patient serum. Through analysis of a support vector machine on characteristic spectral data, a differential diagnosis model can be established for identifying different parotid tumors and providing the objective basis for preoperative diagnosis, thus establishing a quick and noninvasive new diagnosis technique.

Description

technical field [0001] Parotid gland tumors are the most common type of salivary gland tumors, accounting for 64% to 80% of salivary gland tumors. In recent years, the incidence has been increasing year by year. The histopathological classification of parotid gland tumors is complex and there are many types of tumors. According to the histopathological classification of salivary gland tumors in the World Health Organization Classification of Tumors (2005 Edition): Pathology and Genetics of Head and Neck Tumors, the pathological classification of parotid gland tumors includes benign tumors, There are 41 types of malignant tumors, soft tissue tumors, lymphoid hematopoietic system tumors and secondary tumors. This brings difficulties for clinicians and pathologists in the diagnosis and differential diagnosis of parotid gland tumors, and because routine preoperative biopsy is prohibited for parotid gland tumors, its preoperative diagnosis is even more difficult. [0002] With the...

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Problems solved by technology

However, because the Raman signal is weak and susceptible to interference from background fluorescence, its application in the detection of complex biological samples is limited.