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Lotus seed natural medicine combination, preparing method and anti-emesis application

A technology of natural medicines and compositions, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of strong toxic and side effects, large toxic and side effects, and narrow application range, and achieve obvious effects, simple components, and exact curative effects. Effect

Inactive Publication Date: 2014-11-12
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, antiemetic drugs commonly used in clinic mainly include histamine, acetylcholine, dopamine receptor antagonists, bradykinin (NK 1 ) and 5-hydroxytryptamine (5-HT 3 ) receptor antagonists, etc., but these drugs have poor curative effect on vomiting after chemotherapy, and have strong toxic and side effects, so their application is greatly limited
Newer antiemetics, such as NK 1 and 5-HT 3 Although receptor antagonists have good antiemetic effects, they are expensive, have a narrow scope of use, and have large toxic and side effects for central and external use, and often need to be used in combination in clinical practice. Therefore, the creation of new antiemetic drugs is urgently needed

Method used

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  • Lotus seed natural medicine combination, preparing method and anti-emesis application
  • Lotus seed natural medicine combination, preparing method and anti-emesis application
  • Lotus seed natural medicine combination, preparing method and anti-emesis application

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Experimental program
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Effect test

Embodiment 1

[0016] The components of the lotus seed natural medicine composition involved in this embodiment include lotus seed extract and ginger extract gingerol, after the above two raw materials are mixed uniformly in a weight ratio of 5-40:1, according to the process method in the prior art Made into a powdered product, processed into granules, and further made into tablets and / or capsules.

[0017] Its preparation method specifically comprises the following process steps:

[0018] (1) Preparation of lotus seed extract: soak lotus seeds in 15 times the weight of distilled water for 60 minutes, then place them on an electric stove with asbestos net and heat and decoct them for 120 minutes, filter with silk cloth, save the filtrate, and pour the filtered medicine dregs Add 5 times the weight of distilled water, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate the filter membrane, and use a vacuum drying oven at 65°C to dry under reduced pressure for...

Embodiment 2

[0022] In this embodiment, the lotus seed natural medicine composition of the present invention is used for the treatment of vomiting caused by the commonly used anticancer chemotherapeutic drug cisplatin, and the relevant pharmacodynamic studies are as follows:

[0023] (1) Experimental materials: cisplatin (20mg / cart), ondansetron hydrochloride injection (2mL: 4mg), healthy adult mink (male, body weight 1.3-1.8kg), each mink was placed separately in a 75cm×50cm× In a 50cm iron cage, 24 hours of natural light exposure, free to eat and drink before the experiment;

[0024] (2) Experimental method: the minks were randomly divided into 4 groups, 6 in each group, group A was the cisplatin model control group, group B was the ondansetron positive drug group, group C was the gingerol group, and group D was the ondansetron positive drug group. Lotus seed natural medicinal composition group; group A was given normal saline pretreatment, and group B was given ondansetron 7.5 mg·kg -1...

Embodiment 3

[0030] In this embodiment, for the vomiting caused by copper sulfate, the lotus seed natural medicine composition of the present invention is used for administration and treatment, and the relevant pharmacodynamic studies are as follows:

[0031] (1) Experimental materials: copper sulfate, ondansetron hydrochloride injection (2mL: 4mg), healthy adult mink (male, body weight 1.3-1.8kg), each mink is placed in a 75cm×50cm×50cm iron cage , 24 hours of natural light exposure, free to eat and drink before the experiment;

[0032] (2) Experimental method: the minks were randomly divided into 4 groups, 6 in each group, group A was the copper sulfate model control group, group B was the ondansetron positive drug group, group C was the gingerol group, and group D was the ondansetron positive drug group. Lotus seed natural medicinal composition group; group A was given normal saline pretreatment, and group B was given ondansetron 7.5 mg·kg -1 Pretreatment, group C was given gingerol 10...

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Abstract

The invention belongs to the technical field of natural medicine combinations, and relates to a natural medicine combination composed of a lotus seed extractive and a fresh ginger extractive, a preparing method of the natural medicine combination and the function of the natural medicine combination serving as anti-emesis medicine. The natural medicine combination concretely comprises the lotus seed extractive and the fresh ginger extractive (gingerol), and the lotus seed extractive and the gingerol are evenly mixed according to the weight ratio of 5-40:1, prepared into the powdery medicine combination according to a technological method in the prior art, then processed and prepared into granules, and further prepared into tablets and / or capsules. The lotus seed natural medicine combination plays a good role in preparing the medicine for resisting or reliving emesis, is made from pure natural preparations, and is free of toxicant or pollution, obvious in anti-emesis effect and convenient to apply and popularize; the components are simple, the raw materials are easy to obtain, the curative effect is definite, and the natural medicine combination is safe and reliable.

Description

Technical field: [0001] The invention belongs to the technical field of natural medicinal compositions, and relates to a natural medicinal composition composed of lotus seed extract and ginger extract, a preparation method thereof and an antiemetic medicine application thereof. Background technique: [0002] Vomiting is an unbearably painful human response. Improper diet, mental stress, gastrointestinal diseases, cancer radiotherapy and chemotherapy, drug toxicity, postoperative motion sickness and pregnancy can all cause vomiting. Frequent and severe vomiting can cause malnutrition, dehydration, electrolyte imbalance and other complications. In particular, vomiting caused by cancer radiotherapy and chemotherapy is one of the reasons why patients give up treatment. [0003] At present, antiemetic drugs commonly used in clinic mainly include histamine, acetylcholine, dopamine receptor antagonists, bradykinin (NK 1 ) and 5-hydroxytryptamine (5-HT 3 ) receptor antagonists, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P1/02A61K31/12
Inventor 张继国杨杰刘占涛钱秋海岳旺
Owner TAISHAN MEDICAL UNIV
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