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Application of 'Xinnaoxin' capsule in preparation of drugs for treating chronic stress depression

A technology of chronic stress and capsules, which is applied in the field of medicine to achieve the effects of reducing autonomous activities, reducing preference for sugar water, and improving depression-like behavior changes

Inactive Publication Date: 2014-10-22
三普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect has not been reported in antidepressants

Method used

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  • Application of 'Xinnaoxin' capsule in preparation of drugs for treating chronic stress depression
  • Application of 'Xinnaoxin' capsule in preparation of drugs for treating chronic stress depression
  • Application of 'Xinnaoxin' capsule in preparation of drugs for treating chronic stress depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Antidepressant Effect of Xinnaoxin Capsules in Animal Experiments

[0009] 1 Experimental materials

[0010] 1.1 Drugs and reagents

[0011] Xinnaoxin Capsules, the contents are tan powder, 0.5g / capsule, batch number: 120803 Sanpu Pharmaceutical Co., Ltd.; during the experiment, remove the shell of the capsules, grind the contents, and prepare the required concentration with double distilled water. Nimodipine, specification: 30 mg, batch number: BJ09103, Bayer Healthcare Co., Ltd.; during the experiment, it was ground into powder and prepared to the required concentration with double distilled water. MAO, iNOS, and NO kits were purchased from Nanjing Jiancheng Institute of Bioengineering.

[0012] 1.2 Instruments

[0013] Electronic balance (Beijing Sartorius Balance Co., Ltd.); glass cylinder (height 60cm, diameter 20cm, Haimen Glass Instrument Factory); rat open-field experiment device (length 120cm, width 120cm, height 30cm)

[0014] 1.3 Experimental animals

[...

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Abstract

The invention discloses an application of 'Xinnaoxin' capsule in the preparation of drugs for treating chronic stress depression. Research has shown that the autonomic activities of a model rat reduce, the preference degree on sweet water lowers, the static time in forced-swimming tests and tail suspension tests increases, and these animal depression behaviors are all caused by chronic unpredictable stress. The 'Xinnaoxin' capsule can relieve the deterioration of these depression behaviors.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Xinnaoxin capsules in the preparation of medicines for treating chronic stress and depression. Background technique [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worry that you have various diseases, and feeling that you are suffering from various diseases in your body. Discomfort, and in severe cases, suicidal thoughts and behaviors may appear. Depression has a structural abnormality in the cortex-striatum-pallidum-thalamus circuit of the limbic system of the brain. The hippocampus is an important part of the mesolimbic system, which is especially important for emotional regulation and cognitive memory. [0003] Xinnaoxin Capsule is a product of Sanpu Pharmaceutical Co., Ltd., approved by the State Drug Administration Z20025866,...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/48A61P25/24
Inventor 史公权邹存生马俊仓吴留强夏彬牛蓉贺生玲李成秀
Owner 三普药业有限公司
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