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Application of Rhizoma Polygonatum Polysaccharide in the Preparation of Functional Foods with Auxiliary Inhibition of Colon Cancer

A Polygonatum polysaccharide and functional food technology, applied in the field of polysaccharides, achieves the effect of simple process, low cost, and auxiliary inhibition of colon cancer tumors

Active Publication Date: 2016-06-01
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the functions of invigorating qi and nourishing yin, invigorating the spleen, nourishing the lungs, and benefiting the kidney. It is used to treat weak spleen and stomach, fatigue, lack of food, dry cough due to lung deficiency, insufficient essence and blood, and internal heat and thirst. Polygonatum is used as a raw material to prepare polysaccharides, and it is used in the development of a product that assists in the inhibition of colon cancer

Method used

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  • Application of Rhizoma Polygonatum Polysaccharide in the Preparation of Functional Foods with Auxiliary Inhibition of Colon Cancer
  • Application of Rhizoma Polygonatum Polysaccharide in the Preparation of Functional Foods with Auxiliary Inhibition of Colon Cancer
  • Application of Rhizoma Polygonatum Polysaccharide in the Preparation of Functional Foods with Auxiliary Inhibition of Colon Cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Polygonatum polysaccharides in this example are prepared by the following method: take Polygonatum raw material, use boiling water to extract, when extracting for the first time, the consumption of water is 20 times of the total mass of raw material, boil for 5h and filter; when extracting for the second time, water The amount of water used is 20 times the total mass of raw materials, boiled for 3 hours and filtered; for the third extraction, the amount of water used is 10 times the total mass of raw materials, boiled for 2 hours and filtered, combined filtrates, vacuum concentrated to about 1 / 10 of the original volume, and then same. The concentrated solution was treated with trichloroacetic acid to remove protein, and 30% trichloroacetic acid (mass percentage) of the same volume (the same below) was added. After the treatment time was 4 hours, it was neutralized with 10% NaOH (mass percentage), the same below. After the reaction, place the reaction solution in a dialy...

Embodiment 2

[0033] Polygonatum polysaccharides in this embodiment are prepared by the following method: take the raw material of Rhizoma Rhizoma Rhizoma Polygonatum and extract it with boiling water. When extracting for the first time, the amount of water is 15 times the total mass of Rhizoma Rhizoma Rhizoma Polygonatum raw material, boil for 5 hours and filter; when extracting for the second time, The amount of water used is 15 times the total mass of Polygonatum raw material, boiled for 3 hours and filtered; for the third extraction, the amount of water used is 10 times the total mass of Polygonatum raw material, boiled for 3 hours and filtered, combined filtrates, and concentrated in vacuo. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume of 25% trichloroacetic acid (mass percentage) was added. After the treatment time was 3 hours, it was neutralized with 10% NaOH (mass percentage). After neutralization, the reaction solution was plac...

Embodiment 3

[0035] Polygonatum polysaccharides in this example are prepared by the following method: take the raw material of Rhizoma Polygonatum and extract it with boiling water. When extracting for the first time, the amount of water is 10 times the total mass of Rhizoma Rhizoma Polygonatum raw material, boil for 3 hours and filter; when extracting for the second time, The consumption of water is 20 times of the total mass of Polygonatum raw material, boiled for 3 hours and filtered for 3 h; when extracting for the third time, the consumption of water is 10 times of the total mass of Polygonatum raw material, filtered for 5 hours after boiling, combined filtrate, concentrated in vacuum, and concentrated solution was carried out three times. Chloroacetic acid protein removal treatment, add the same volume of 15% trichloroacetic acid (mass percentage), after the treatment time is 5 hours, neutralize with 10% NaOH (mass percentage), after neutralization, put the reaction solution in a dialy...

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Abstract

The invention discloses an application of polygonatum polysaccharide in the preparation of drugs for assisting the inhibition of colon cancer. The polygonatum polysaccharide is preferably prepared through the following steps: adopting polygonatum sibiricum as the raw material, extracting the polygonatum sibiricum with boiling water, removing the proteins, carrying out dialysis, and finally carrying out an ethanol treatment so as to obtain the polygonatum polysaccharide. The polygonatum polysaccharide can modulate the tumor micro-environment by inhibiting the tumor from generating new vessels, carrying out immunity inhibition, carrying out anti-oxidation, inhibiting the growth of colon cancer fibroblast, and the like. Thus the polygonatum polysaccharide has a very good auxiliary effect on inhibiting the colon tumor.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to the application of polygonatum polysaccharides in the preparation of functional foods with the effect of assisting in inhibiting colon cancer. Background technique [0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Therefore, looking for Anticancer drugs with high efficiency and low toxicity are of great significance. In recent years, studies have found that polysaccharides have significant anti-tumor activity and have relatively small toxic and side effects on the human body. The research on the biological activity of polysaccharides has become a hot spot for experts and scholars at home and abroad in the medical field. In recent ye...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L29/30C08B37/00
CPCA23L29/30A23V2002/00C08B37/0003A23V2200/308A23V2250/51A23V2250/21A23V2300/14
Inventor 梁明王培培马方励胡明华
Owner INFINITUS (CHINA) CO LTD
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