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Application of polygonatum polysaccharide in preparation of drugs for assisting inhibition of colon cancer

A Polygonatum polysaccharide and functional food technology, applied in the field of polysaccharides, achieves the effects of stable and efficient process, low cost and simple process

Active Publication Date: 2014-10-22
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the functions of invigorating qi and nourishing yin, invigorating the spleen, nourishing the lungs, and benefiting the kidney. It is used to treat weak spleen and stomach, fatigue, lack of food, dry cough due to lung deficiency, insufficient essence and blood, and internal heat and thirst. Polygonatum is used as a raw material to prepare polysaccharides, and it is used in the development of a product that assists in the inhibition of colon cancer

Method used

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  • Application of polygonatum polysaccharide in preparation of drugs for assisting inhibition of colon cancer
  • Application of polygonatum polysaccharide in preparation of drugs for assisting inhibition of colon cancer
  • Application of polygonatum polysaccharide in preparation of drugs for assisting inhibition of colon cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Polygonatum polysaccharides in this example are prepared by the following method: take Polygonatum raw material and extract it with boiling water. For the first extraction, the amount of water used is 20 times the total mass of the raw material, boiled for 5 h and filtered; for the second extraction, The amount of water used is 20 times the total mass of raw materials, boiled for 3 h and filtered; for the third extraction, the amount of water used is 10 times the total mass of raw materials, boiled for 2 h and filtered, combined filtrates, vacuum concentrated to about 1 / of the original volume 10, the same below. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume (the same below) of 30% trichloroacetic acid (mass percentage) was added. After the treatment time was 4 hours, it was neutralized with 10% NaOH (mass percentage), the same below, After neutralization, place the reaction solution in a dialysis bag and tie it f...

Embodiment 2

[0033] Polygonatum polysaccharides in this example are prepared by the following method: take the raw material of Rhizoma Polygonatum and extract it with boiling water. When extracting for the first time, the amount of water used is 15 times the total mass of Rhizoma Rhizoma Polygonatum raw material, boil for 5 h and filter; , the amount of water used was 15 times the total mass of Polygonatum raw material, boiled for 3 h and filtered; for the third extraction, the amount of water used was 10 times the total mass of Polygonatum raw material, boiled for 3 h and filtered, the filtrates were combined and concentrated in vacuo. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume of 25% trichloroacetic acid (mass percentage) was added. After the treatment time was 3 h, it was neutralized with 10% NaOH (mass percentage). After neutralization, the reaction solution was placed in Dialyze in a dialysis bag, then concentrate the liquid i...

Embodiment 3

[0035] Polygonatum polysaccharides in this example are prepared by the following method: take the raw material of Polygonatum and extract it with boiling water. When extracting for the first time, the amount of water used is 10 times the total mass of Polygonatum raw material, boil for 3 h and filter; , the consumption of water is 20 times of the total mass of Polygonatum raw material, boiled for 3 h and filtered for 3 h; during the third extraction, the consumption of water is 10 times of the total mass of Polygonatum raw material, boiled for 5 h and filtered, combined filtrate, concentrated in vacuo, concentrated solution Perform trichloroacetic acid protein removal treatment, add the same volume of 15% trichloroacetic acid (mass percentage), after a treatment time of 5 hours, neutralize with 10% NaOH (mass percentage), and place the reaction solution in a dialysis bag after neutralization Dialyze in the middle bag, then concentrate the liquid in the dialysis bag, centrifuge,...

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Abstract

The invention discloses an application of polygonatum polysaccharide in the preparation of drugs for assisting the inhibition of colon cancer. The polygonatum polysaccharide is preferably prepared through the following steps: adopting polygonatum sibiricum as the raw material, extracting the polygonatum sibiricum with boiling water, removing the proteins, carrying out dialysis, and finally carrying out an ethanol treatment so as to obtain the polygonatum polysaccharide. The polygonatum polysaccharide can modulate the tumor micro-environment by inhibiting the tumor from generating new vessels, carrying out immunity inhibition, carrying out anti-oxidation, inhibiting the growth of colon cancer fibroblast, and the like. Thus the polygonatum polysaccharide has a very good auxiliary effect on inhibiting the colon tumor.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to the application of polygonatum polysaccharides in the preparation of functional foods with the effect of assisting in inhibiting colon cancer. Background technique [0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Therefore, looking for Anticancer drugs with high efficiency and low toxicity are of great significance. In recent years, studies have found that polysaccharides have significant anti-tumor activity and have relatively small toxic and side effects on the human body. The research on the biological activity of polysaccharides has become a hot spot for experts and scholars at home and abroad in the medical field. In recent ye...

Claims

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Application Information

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IPC IPC(8): A23L1/09C08B37/00
CPCA23L29/30A23V2002/00C08B37/0003A23V2200/308A23V2250/51A23V2250/21A23V2300/14
Inventor 梁明王培培马方励胡明华
Owner INFINITUS (CHINA) CO LTD
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