A glipizide compound, a pharmaceutical composition containing the compound, and a preparation method thereof
A technology of glipizide and its composition, which is applied in the field of glipizide compound and pharmaceutical composition containing the compound and its preparation, can solve problems such as poor compliance, low solubility of glipizide, difficulty in swallowing, etc., and achieve Consistent dissolution rate, excellent in vitro dissolution, and improved water solubility
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Embodiment 1
[0043] [embodiment 1] preparation of glipizide compound
[0044]Get glipizide crude drug 500g, add the mixed solution of DMF / isopropanol, wherein the volume ratio of DMF and isopropanol is 2:1, the consumption ratio of glipizide crude drug and mixed solution is 1g: 10ml, Heat to 40°C, after the glipizide raw material is dissolved, add activated carbon for decolorization, the amount of added activated carbon is 0.2% g / ml of the total volume of the liquid, stir and adsorb for 25 minutes, filter for decarbonization and sterilization; the filtrate is transferred to the reaction In the kettle, slowly add acetone at a stirring rate of 25r / min, the volume ratio of acetone to the mixed solution is 3:1, after the addition is complete, cool down to 0°C, filter, wash with acetone for 3 times, and dry under reduced pressure for 5h. A white crystalline powder was obtained.
[0045] Gained white crystalline powder uses Cu-Kα ray to measure the X-ray powder diffraction pattern that obtains ...
Embodiment 2
[0046] [embodiment 2] preparation of glipizide compound
[0047] Get glipizide bulk drug 500g, add the mixed solution of DMF / isopropanol, wherein the volume ratio of DMF and isopropanol is 4:1, the consumption ratio of glipizide bulk drug and mixed solution is 1g: 15ml, Heat to 45°C, after the glipizide raw material is dissolved, add activated carbon for decolorization, the amount of added activated carbon is 0.2% g / ml of the total volume of the liquid, stir and adsorb for 25 minutes, filter for decarbonization and sterilization; the filtrate is transferred to the reaction In the kettle, slowly add acetone under the condition of a stirring rate of 30r / min, the volume ratio of acetone to the mixed solution is 6:1, after the addition is completed, cool down to 5°C, filter, wash with acetone for 3 times, and dry under reduced pressure for 5h. A white crystalline powder was obtained.
[0048] Gained white crystalline powder uses Cu-Kα ray to measure the X-ray powder diffraction p...
Embodiment 3
[0049] [embodiment 3] preparation of glipizide compound
[0050] Get glipizide bulk drug 500g, add the mixed solution of DMF / isopropanol, wherein the volume ratio of DMF and isopropanol is 3:1, the consumption ratio of glipizide bulk drug and mixed solution is 1g: 12ml, Heat to 42°C, after the glipizide raw material is dissolved, add activated carbon for decolorization, the amount of added activated carbon is 0.2% g / ml of the total volume of the liquid, stir and adsorb for 25 minutes, filter for decarbonization and sterilization; the filtrate is transferred to the reaction In the kettle, slowly add acetone at a stirring rate of 28r / min, the volume ratio of acetone to the mixed solution is 5:1, after the addition is complete, cool down to 3°C, filter, wash with acetone for 3 times, and dry under reduced pressure for 5h. A white crystalline powder was obtained.
[0051] Gained white crystalline powder uses Cu-Kα ray to measure the X-ray powder diffraction pattern that obtains a...
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