A calcium phosphate-based composite self-curing bone repair material and its preparation method

Abstract

The invention discloses a calcium phosphate-based compound self-setting bone repair material and a preparation method thereof. A novel calcium phosphate-based compound self-setting bone repair material is prepared by combining brushite bone cement which is quick to set and degrade and has bioactivity and osteoconduction with hydroxyapatite cement which is good in mechanical property and biocompatibility supplemented by a structure enhancing and a doping and modifying technology, wherein the initial setting time of the bone repair material is 3-10 minutes, the final setting time is 12-20 minutes, the compressive strength after solidification is 21.2-40.0MPa, and the degradation rate within 14 days can reach 18.2%, so that the bone repair material is suitable for repairing bone defects in non-loading parts of human bodies. Compared with the prior art, the material and the preparation method provided by the invention have the advantages that the cost is low, the product quality is stable, the mechanics combination property is excellent, the biodegradability, osteoconduction and X ray resistance are good, the material of the invention can slowly release strontium ions, thus prolonging pharmacologic treating efficacy of the strontium ions to the implanting position, and being applicable to the industrialized mass production.

Description

[0001] Technical field: [0002] The invention belongs to the field of medical materials for bone defect repair, in particular to a novel calcium phosphate-based composite self-curing bone repair material. [0003] Background technique: [0004] The repair of fractures and bone defects is a long-term unresolved major problem in the field of orthopedics. Bone transplantation is the main means and method for the treatment of bone defects, including autologous bone transplantation, allogeneic bone transplantation, bioceramics and bone cement. Autologous bone grafting is one of the most effective materials for repair and reconstruction. However, this method must sacrifice part of the normal tissue of the human body to repair the diseased or defective bone, which increases surgical trauma, and the source of bone supply is limited. Accurate shaping of the site, excavation of flesh to mend sores, and healing of wounds with trauma will cause the patient to suffer from the pain of a sec...

AI Technical Summary

Problems solved by technology

But PMMA bone cement has the following problems in clinical application: strong exothermicity in the curing process can cause damage to surrounding tissues; the solidified body has poor biocompatibility and cannot degrade in vivo; The carrier of the substance, thus limiting its clinical application

However, there are still some defects in the application of this material, which are mainly reflected in: brushite bone cement is acidic, and implantation in the body may cause slight inflammatory reactions in surrounding tissues; although it solidifies quickly and has a high degradation rate, After solidification, the structure is loose, the porosity is high, and the strength is low, so it can only be used for the repair of non-load-bearing bone defects

[0012] According to the search, there are already several patent applications related to hydroxyapatite calcium phosphate bone cement in China (application numbers are 201010232747.1; preparation and modification of brushite bone cement; and fewer patent applications involving brushite bone cement (application number is 200710047442.1)

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