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Natural polysaccharide/nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing and radiation synthesis method thereof

A natural polysaccharide and composite hydrogel technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as limiting the application of functional materials, achieve the effect of keeping the wound environment moist, promoting wound healing, and simplifying the production process

Active Publication Date: 2014-09-17
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single-component materials often have deficiencies in practical applications (especially in terms of mechanical properties and biological and physiological functions), which limit their application as functional materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Take 3.64 g of carboxymethyl chitosan, nano-TiO 2 0.036 g, polyvinyl alcohol (polymerization degree 1670) 0.036 g, sodium dihydrogen phosphate 0.364 g, Tween 0.036 g and water 32 ml for later use;

[0037] 2. Take 25 ml of the above deionized water, nano-TiO 2 , Tween were added to the container in turn, placed in an ultrasonic generator and ultrasonicated for 1 h to form stable nano-TiO 2 Emulsion system;

[0038] 3. Take polyvinyl alcohol (polymerization degree 1670) and put it into 7 ml of deionized water at 95 °C, stir at 150 r / min, heat and stir for 2 h, after completely dissolving, cool to 50 °C, add carboxymethyl Chitosan and sodium dihydrogen phosphate were stirred for 1 h to completely dissolve and form a uniform solution;

[0039] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 The emulsion system was mixed, stirred for 0.5 h, then allowed to stand for 2 h, vacuumized and defoamed, and injected into a 15×5×1 mm 3 In the P...

Embodiment 2

[0045] 1. Take 40 g of sodium carboxymethyl cellulose, 3 g of collagen, 5 g of P25, and nano-TiO sensitized with CdTe quantum dots 2 5 g, 3 g of sodium hydroxide, 1 g of Span, 1 g of Tween, 1 g of Brij and 43 ml of water for later use;

[0046] 2. Take 17 ml of the above deionized water, P25, CdTe quantum dot sensitized nano-TiO 2 , Span, Tween, and Brij were added to the container in turn, placed in an ultrasonic generator and ultrasonicated for 1 h to form stable nano-TiO 2 Emulsion system;

[0047] 3. Put 40 g sodium carboxymethyl cellulose, 3 g collagen, and 3 g sodium hydroxide into 26 ml deionized water at 35 °C, heat and stir for 2 h, and add nano-TiO 2 In the colloidal system;

[0048] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 The colloidal system was mixed, stirred for 0.5 h, and then left to stand for 2 h. The uniformly stirred jelly-like sample was ground and pressed into a ball, and after being pressed with a tablet machine,...

Embodiment 3

[0054] 1. Take 1 g of bacterial cellulose and Se-doped nano-TiO 2 0.1 g, polyvinyl alcohol (polymerization degree 1670) 6 g, sodium dihydrogen phosphate 0.1 g, disodium hydrogen phosphate 0.1 g, glyceryl monostearate 0.1 g, Myrij 0.1 g and water 50 ml for later use;

[0055] 2. Take 25 ml of the above deionized water, Se-doped and modified nano-TiO 2 , glyceryl monostearate, and Myrij were added to the container in turn, placed in an ultrasonic generator and ultrasonicated for 1 h to form stable nano-TiO 2 Emulsion system;

[0056] 3. Take polyvinyl alcohol (polymerization degree 1670) and put it into 25 ml deionized water at 95 ℃, stir at 150 r / min, heat and stir for 2 h, after completely dissolving, cool to 50 ℃, add bacterial cellulose respectively , disodium hydrogen phosphate, sodium dihydrogen phosphate, stirred for 1 h to completely dissolve to form a uniform solution;

[0057] 4. Mix the solution obtained in step 3 with the nano-TiO obtained in step 2 2 The emulsi...

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Abstract

The invention provides a natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing which is composed of a backing layer, a hydrogel dressing layer and a strippable layer. A synthesis method of the natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing comprises performing radiation crosslinking on raw materials, namely 10-40% of natural polysaccharide, 0.1-10% of nano-TiO2, 0.1%-5% of radiation sensitizer, 0.1%-3% of pH regulator, 0.1%-3% of surfactant and 60%-95% of water, by use of an electron beam or gamma ray by a radiation dose of 10-150kGy and at a dose rate of 10-80kGy / pass. The natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing is sheared, bagged and sterilized by radiation, and then stored for a long time. The natural polysaccharide / nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing has the advantages that the maximization and optimization of the properties of the composite hydrogel, light-sensitive and antimicrobial properties are united organically, and the multiple-element composite synergic antimicrobial effect of the nano-TiO2-natural polysaccharide hydrogel is also realized; meanwhile, the composite hydrogel dressing has the characteristics of air permeability, no bonding with tissues, good flexibility and the like, and thus is suitable for protecting and treating various wounds.

Description

technical field [0001] The invention relates to a nanocomposite hydrogel antibacterial dressing, in particular to a natural polysaccharide / nano TiO 2 Composite hydrogel photosensitive antibacterial dressing and radiation synthesis method. Background technique [0002] Traditional hydrogel dressings have the advantages of absorbing wound exudate, keeping the wound moist, reducing scar formation, and promoting wound healing, and have attracted more and more attention. It is especially suitable for the protection and treatment of wounds, scalds, burns and other wounds. These hydrogel dressing products are generally thick, which increases the production cost, weakens the comfort of the product to a certain extent, and does not have a good antibacterial effect under natural light. From the perspective of the structure of traditional hydrogel dressing products, there is a certain air permeability, but the water absorption capacity of the ordinary adhesive layer is not strong, wh...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44C08J3/28C08J3/24C08J3/075
Inventor 李月生赵龙
Owner HUBEI UNIV OF SCI & TECH
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